A5090847315- MicroRNA in disease regulation
- Chromosomal and Genetic Variations
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Human-Animal Interaction Studies
- Animal Genetics and Reproduction
- Genomics and Phylogenetic Studies
- Circular RNAs in diseases
- Aquaculture disease management and microbiota
- Identification and Quantification in Food
- CRISPR and Genetic Engineering
- interferon and immune responses
- Global Education and Multiculturalism
- Digital Games and Media
- Autophagy in Disease and Therapy
- Consumer Perception and Purchasing Behavior
- Neurogenesis and neuroplasticity mechanisms
- Genetic and rare skin diseases.
- Genetic diversity and population structure
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Hedgehog Signaling Pathway Studies
- Asian Culture and Media Studies
- Biochemical effects in animals
- Alzheimer's disease research and treatments
Pohang University of Science and Technology
2022-2023
Korea Research Institute of Bioscience and Biotechnology
2020-2022
Pusan National University
2013-2021
Humboldt-Universität zu Berlin
2020
Korea Institute of Oriental Medicine
2015-2019
Korea Advanced Institute of Science and Technology
2014
Seoul National University
2007
Plant peroxisomes play a pivotal role during postgerminative growth by breaking down fatty acids to provide fixed carbons for seedlings before the onset of photosynthesis. The enzyme composition changes transition seedling from heterotrophic an autotrophic state; however, mechanisms degradation obsolete peroxisomal proteins remain elusive. One candidate mechanism is autophagy, bulk pathway targeting cytoplasmic constituents lytic vacuole. We present evidence supporting autophagy in...
Oxidative stress is involved in neuronal cell death and mitochondrial dysfunction neurodegenerative diseases. Liriope platyphylla (LP) has been suggested to have anti-inflammation, anti-bacterial, anti-cancer effects. However, whether LP exerts neuroprotective effects on cells unknown. The present study was performed investigate the of extract (LPE) against hydrogen peroxide (H2O2)-induced injury human neuroblastoma SH-SY5Y. To test LPE, we viability assay, flow cytometry analysis western...
Aloe vera ethanol extract (AVE) reportedly has significant anti-influenza virus activity, but its underlying mechanisms of action and constituents have not yet been completely elucidated. Previously, we confirmed that AVE treatment significantly reduces the viral replication green fluorescent protein-labeled influenza A in Madin-Darby canine kidney (MDCK) cells. In addition, post-treatment with inhibited matrix protein 1 (M1), 2 (M2), hemagglutinin (HA) mRNA synthesis (M1, M2, HA)...
Eupatorium fortunei (EF) has long been used as herbal medicine in Korea, China, and Asian countries to treat a variety of diseases. Recent studies have reported that EF anti-metastatic, anti-angiogenic, anti-bacterial, anti-oxidant activities, well activities against malignant metastatic human cancers. The effect its components on viruses not reported. In the present study, antiviral activity mechanism action an aqueous extract (WEF) were evaluated vitro. We found pretreatment with WEF...
Influenza is an acute respiratory illness caused by the influenza A virus, which causes economic losses and social disruption mainly increasing hospitalization mortality rates among elderly people with chronic diseases. vaccines are most effective means of preventing seasonal influenza, but can be completely ineffective if there antigenic mismatch between vaccine virus circulating in community. In addition, viruses resistant to antiviral drugs emerging worldwide. Thus, urgent need develop...
We investigated the anti-amnesic effects of SJ and fermented (FSJ) on scopolamine (SCO)-induced amnesia mouse model. Mice were orally co-treated with or FSJ (125, 250, 500 mg/kg) SCO (1 mg/kg), which was injected intraperitoneally for 14 days. decreased step-through latency prolonged time to find hidden platform in passive avoidance test Morris water maze test, respectively, both ameliorated by treatment. discovered promote hippocampal neurogenesis during treatment increasing proliferation...
Olive flounder (Paralichthys olivaceus) is one of economically valuable fish species in the East Asia. In comparison with its economic importance, available genomic information olive very limited. The mass mortality caused by variety pathogens (virus, bacteria and parasites) main problem aquaculture industry, including culture. this study, we carried out transcriptome analysis using gill tissues after infection three types (Virus; Viral hemorrhagic septicemia virus, Bacteria; Streptococcus...
Linear nevus sebaceous syndrome (LNSS) is a neurocutaneous disorder caused by somatic gain-of-function mutations in KRAS or HRAS. LNSS brains have neurodevelopmental defects, including cerebral defects and epilepsy; however, its pathological mechanism potentials for treatment are largely unclear. We show that introduction of KRASG12V the developing mouse cortex results subcortical nodular heterotopia enhanced excitability, recapitulating major manifestations LNSS. Moreover, we decreased...
Abstract Endogenous retroviruses (ERVs) have been identified at different copy numbers in various organisms. The long terminal repeat (LTR) element of an ERV has the capacity to exert regulatory influence as both a promoter and enhancer cellular genes. Here, we describe olive flounder (OF)-ERV9, derived from chromosome 9 flounder. OF-ERV9-LTR provide binding sites for transcription factors showed activity. demonstrates high sequence similarity with 3′ untranslated region (UTR) genes that...