A5029189610- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer survivorship and care
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Mathematical Biology Tumor Growth
- Olfactory and Sensory Function Studies
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Angiogenesis and VEGF in Cancer
- Breast Cancer Treatment Studies
- COVID-19 and healthcare impacts
- Immunotherapy and Immune Responses
- Advances in Oncology and Radiotherapy
- Palliative Care and End-of-Life Issues
- Economic and Financial Impacts of Cancer
- Management of metastatic bone disease
- Chronic Disease Management Strategies
Centre Hospitalier du Mans
2015-2024
Centre Jean Bernard
2014-2023
Clinique Victor Hugo
2010-2023
Université Paris Cité
2021-2022
Hôpital Bretonneau
2001-2021
Institut National du Cancer
2019
Normandie Université
2015-2018
Complexe de Recherche Interprofessionnel en Aérothermochimie
2015-2018
Centre National de la Recherche Scientifique
1990-2018
Institut National des Sciences Appliquées Rouen Normandie
2015-2018
We report the 5-year survival and late toxicity results of a randomized clinical trial, which showed 3-year improvement in overall locoregional control stage III or IV oropharynx carcinoma, using concomitant radiochemotherapy (arm B), compared with standard radiotherapy A).A total 226 patients were entered onto phase multicenter trial comparing alone (70 Gy 35 fractions; arm A) fractions three cycles 4-day regimen comprising carboplatin fluorouracil; B). Prognostic factors evaluated by...
This study reports 2-year survival outcomes among patients with advanced nonprogressive stage IIA to IV lung cancer randomized symptom monitoring during chemotherapy via web-based patient-reported vs standard scheduled imaging after treatment detect symptomatic recurrence.
The use of web-based monitoring for lung cancer patients is growing in interest because promising recent results suggesting improvement and resource utilization outcomes. It remains an open question whether the overall survival (OS) these could be improved by using a web-mediated follow-up rather than classical scheduled imaging.Advanced-stage without evidence disease progression after or during initial treatment were randomly assigned multicenter phase III trial to compare algorithm...
The open-label, phase III EVOKE-01 study evaluated sacituzumab govitecan (SG) versus standard-of-care docetaxel in metastatic non-small cell lung cancer (mNSCLC) with progression on/after platinum-based chemotherapy, anti-PD-(L)1, and targeted treatment for actionable genomic alterations (AGAs). Primary analysis is reported.
We retrospectively compared survivals in patients with a lung cancer history and followed by the so-called sentinel Web-application that allows early detection of relapse palliative care initiation versus conventional follow-up our center.The survival 98 consecutive was assessed. The first part them (the control arm) recruited between March 2011 August 2012. second half experimental prospectively 2012 December 2013 to weekly fill form 11 self-assessed symptoms, then processed "sentinel"...
Patients with advanced non-small-cell lung cancer (NSCLC) treated immune checkpoint blockers (ICBs) ultimately progress either rapidly (primary resistance) or after durable benefit (secondary resistance). The vaccine OSE2101 may invigorate antitumor-specific responses ICB failure. objective of ATALANTE-1 was to evaluate its efficacy and safety in these patients. a two-step open-label study the compared standard-of-care (SoC) chemotherapy (CT). human leukocyte antigen (HLA)-A2-positive NSCLC...
The findings in seventy-one patients who had previously untreated spinal deformities associated with dystrophic changes and neurofibromatosis were reviewed to identify the risk factors for progression of curve as well natural history patterns. Four different types curves evaluated. Two them most severe progression: (1) kyphoscoliosis angular kyphosis (gibbus) marked (2) so-called kyphosing scoliosis (a that has so much rotation [90 degrees] is evident only on lateral roentgenogram) a round...
See an invited perspective on this article page 1043. This multicenter phase II study investigated a selective radiotherapy dose increase to tumor areas with significant <sup>18</sup>F-misonidazole (<sup>18</sup>F-FMISO) uptake in patients non–small cell lung carcinoma (NSCLC). <b>Methods:</b> Eligible had locally advanced NSCLC and no contraindication concomitant chemoradiotherapy. The <sup>18</sup>F-FMISO PET/CT was assessed by trained experts. If there uptake, 66 Gy were delivered. In...
We developed a self-triage web application for COVID-19 symptoms, which was launched in France March 2020, when French health authorities recommended all patients with suspected call an emergency phone number.Our objective to determine if tool could reduce the burden on centers and help predict increasing hospitals.Users were asked questions about their underlying conditions, sociodemographic status, postal code, main symptoms. Participants advised center they reported dyspnea or complete...
Background Prognostic models based on individual patient characteristics can improve treatment decisions and outcome in the future. In many (radiomic) studies, small size heterogeneity of datasets is a challenge that often limits performance potential clinical applicability these models. The current study example retrospective multi-centric with challenges caveats. To highlight common issues emphasize pitfalls, we aimed for an extensive analysis multi-center pre-treatment datasets,...
Persistent olfactory dysfunction is a significant complication of SARS-CoV-2 infection. Olfactory training involving aromatic oils has been recommended to improve recovery, but quantitative data are missing.We aimed quantify the benefit and visual stimulation assisted by dedicated web application for patients who experienced ≥1 month.We performed an observational, real-life, data-based study on cohort at least 1 month persistent between January 30 March 26, 2021. An analysis was after mean...
Abstract Purpose: To investigate whether dietary docosahexaenoic acid (DHA), a peroxidizable polyunsaturated ω-3 fatty acids, sensitizes rat mammary tumors to anthracyclines and its action interferes with tumor vascularization, critical determinant of growth. Experimental Design: Female Sprague-Dawley rats were initiated by N-methylnitrosourea develop then assigned control group (n = 18), receiving supplementation palm oil, or DHA 54), supplemented microalgae-produced oil (DHASCO, 1.5 g/d)....
Glioblastomas (GBM) may receive inadequate radiation dose coverage, specially the nonenhanced hypercellular component, using post-Gd T1 weighted and T2 FLAIR images for target definition.A mixture of edema, micronecrosis, tumor cells normal tissue in a single image voxel result an unpredictable value on diffusion conventional b-value 1000 s/mm 2 or less.This study aimed to develop technique identify components GBM by high imaging (DWI) suppress fluid, micro-necrosis even extent.The volume...
Background We developed a self-assessment and participatory surveillance web application for coronavirus disease (COVID-19), which was launched in France March 2020. Objective Our objective to determine if self-reported symptoms could help monitor the dynamics of COVID-19 outbreak France. Methods Users were asked questions about underlying conditions, sociodemographic status, zip code, symptoms. Depending on reported presence coexisting disorders, users told either stay at home, contact...