A5045688990- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Music Therapy and Health
- Pleural and Pulmonary Diseases
- Respiratory Support and Mechanisms
- Neuroscience and Music Perception
- Cystic Fibrosis Research Advances
- Lung Cancer Research Studies
- Neuroscience of respiration and sleep
- Sarcoidosis and Beryllium Toxicity Research
- Mycobacterium research and diagnosis
- Airway Management and Intubation Techniques
- Trauma Management and Diagnosis
- Obstructive Sleep Apnea Research
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Glutathione Transferases and Polymorphisms
- Parkinson's Disease and Spinal Disorders
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Peripheral Nerve Disorders
UCLouvain
2010-2022
Cliniques Universitaires Saint-Luc
2013-2022
Directorate-General Joint Research Centre
2021
Erasmus Hospital
2020
Centre Hospitalier Universitaire de Liège
2020
Weatherford College
2020
Queen Astrid Military Hospital
2008-2016
Service de la Santé Publique
2015
Leefmilieu Brussel
2004
Palacký University Olomouc
2001
The open-label, phase III EVOKE-01 study evaluated sacituzumab govitecan (SG) versus standard-of-care docetaxel in metastatic non-small cell lung cancer (mNSCLC) with progression on/after platinum-based chemotherapy, anti-PD-(L)1, and targeted treatment for actionable genomic alterations (AGAs). Primary analysis is reported.
Previous studies have generally shown poor effective long-term compliance with nasal continuous positive airway pressure (nCPAP) in patients obstructive sleep apnoea syndrome (OSAS). We performed a retrospective study of treated nCPAP for more than one year. Compliance was defined as the average number hours use per day, where were obtained from built-in time counter device, after deduction 10% difference between and counters previously by others. present data on first 95 whom results...
A clinicoradiological presentation of thoracic sarcoidosis requires histopathology in order to establish the diagnosis. Flexible bronchoscopy has a reasonable diagnostic yield and is procedure first choice for Endoscopic ultrasound (endoscopic ultrasound-guided fine needle aspiration/endobronchial transbronchial aspiration) can help diagnosis sarcoidosis. An implementation strategy endoscopic following negative flexible results was examined prospectively 15 clinics. total 137 patients (92...
Multidrug resistant Acinetobacter baumannii and its closely related species A. pittii nosocomialis, all members of the calcoaceticus-baumannii (Acb) complex, are a major cause hospital acquired infection. In burn wound center Queen Astrid military in Brussels, 48 patients were colonized or infected with Acb complex over 52-month period. We report molecular epidemiology these organisms, their clinical impact infection control measures taken. A representative set 157 isolates was analyzed...
Abstract The concept of progressive fibrosing interstitial lung disease (PF-ILD) has recently emerged. However, real-life proportion PF-ILDs outside IPF is still hard to evaluate. Therefore, we sought estimate the PF-ILD in our ILD cohort. We also determined subtypes within and investigated factors associated with PF-ILDs. Finally, quantified interobserver agreement between radiologists for assessment fibrosis. reviewed files patients discussed multidisciplinary discussion January 1st 2017...
In humans, malnutrition alters the respiratory system in different ways. It impairs ventilatory drive, decreases muscle strength and reduces immune competence. addition, typical emphysema-like changes were demonstrated starved animals. The presence of emphysema has never been humans. Our objective was to investigate whether pulmonary occurs anorexia nervosa by means a function study.We examined 24 women aged between 14 38 years (nine smokers). We studied lung including volumes, capacity,...
To test the hypothesis that sarcoidosis is associated with an intravascular leakage of lung epithelium secretory proteins, occurrence and determinants in serum sarcoid patients CC16, a small size readily diffusible lung-specific protein 16 kDa secreted by bronchiolar Clara cells, was investigated. CC16 measured sensitive latex immunoassay 117 established healthy subjects matched for age, sex smoking status. Stepwise regression analysis used to identify extrapulmonary variables changes serum....
Background. Transbronchial lung cryobiopsies (TBLCs) are a promising diagnostic tool in the setting of diffuse parenchymal diseases (DPLDs). However, no comparison with surgical biopsy (SLB) same patient is available. Methods. The yield and safety data TBLCs, as well result SLB performed after were analysed multicentric Belgian study. A was TBLCs absence definite pathological diagnosis or if NSIP pattern observed without related condition identified following multidisciplinary discussion....
<h3>BACKGROUND:</h3> Pulmonary rehabilitation is a key element in the treatment of COPD. Music has been shown to have positive effect on parameters related decrease exercise tolerance. The aim this study was evaluate listening ambient music perceived exertion during pulmonary session for COPD subjects. <h3>METHODS:</h3> subjects randomly performed with or without music. Perceived (Borg scales), anxiety (Hospital Anxiety and Depression Scale-Anxiety Subscale), dyspnea (visual analog scale),...
A multicenter study was performed to determine an optimal workflow for liquid biopsy in a clinical setting. In total, 549 plasma samples from 234 non-small cell lung cancer (NSCLC) patients were collected. Epidermal Growth Factor Receptor (EGFR) circulating cell-free tumor DNA (ctDNA) mutational analysis using digital droplet PCR (ddPCR). The influence of (pre-) analytical variables on ctDNA investigated. Sensitivity influenced by interplay between increased volume (p < 0.001) and short...
The guidelines on idiopathic pulmonary fibrosis (IPF) diagnosis established the crucial role of multidisciplinary discussion (MDD) in interstitial lung diseases (ILD). However, real-life evaluation MDD remains scarce. Our aim was to study impact a well-structured etiological assessment, diagnosis, and management ILD.We collected analysed all relevant data patients concerning treatment before after during year 2017.One hundred fifty were included analysis. had significant management: 42%...
Background Dental technicians are potentially exposed to various occupational dusts and chemicals. Not surprisingly, related lung diseases have been documented in this population. Methods We describe the case of a dental laboratory technician presenting progressive exertional dyspnea cough. used function tests, computed tomography, histological examination, mineralogical immunological studies characterize his condition. Results Lung disclosed restrictive pattern with low diffusion capacity....
Abstract Background Although increasing data supports the use of transbronchial lung cryobiopsies (TBLCs) for diagnosis diffuse parenchymal diseases (DPLDs), its role as an alternative to surgical biopsy (SLB) is still under debate. The aim this study was assess benefit additional SLBs performed in selected patients after TBLCs. Method We conducted a multicentric Belgian prospective trial which were TBLCs when pathological uncertain or if nonspecific interstitial pneumonia (NSIP) pattern...
Background To evaluate pulmonary function, pain, and quality of life at midterm after robotic lobectomy performed in a single institution. Methods Sixty-five consecutive patients underwent thoracic surgery over 32 months using complete four-arm portal technique. Sixty-one lobectomies predominantly for stage I non-small cell lung cancer. Pulmonary function tests were repeated follow-up. Pain evaluated during the follow-up on subgroup 39 patients, excluding learning period. Results At mean...
Cough is one of the three major symptoms reported by chronic obstructive pulmonary disease (COPD) patients. The Leicester Questionnaire (LCQ) a questionnaire exploring impact cough, but it does not exist in French. aim this study was to develop French version LCQ and assess its psychometrics properties. A forward–backward translation process used LCQ. COPD patients completed Sputum Assessment (CASA-Q) determine concurrent validity, content validity internal consistency. Two weeks later,...
The nasal vestibule is a major site of resistance to airflow in healthy subjects. A high may increase snoring. Activation the alae nasi and alar retraction reduce improve ventilation. Breathe Right (BR) device has been proposed or eliminate snoring by improving breathing. We assessed efficacy BR on sleep quality during 2 full-night polysomnographies, first without second with BR. Ten non-apnoeic snorers were studied. Snoring was present 22-98% total time control night. Ear-nose-throat...
The viral pandemic coronavirus disease 2019 (COVID-19) has disrupted cancer patient management around the world. Most reported data relate to incidence, risk factors, and outcome of severe COVID-19. safety systemic anti-cancer therapy in oncology patients with non-severe COVID-19 is an important matter daily practice.ONCOSARS-1 was a single-center, academic observational study. Adult solid tumors treated day unit during initial phase Belgium were prospectively included. All (n = 363)...
TPS8118^ Background: Hsp90 is a molecular chaperone recognized as key facilitator of cancer cell growth and survival. Ganetespib resorcinolic inhibitor that has shown single-agent activity in patients with lung, breast, other cancers after progression on standard treatments. combination docetaxel induces synergistic efficacy human non-small-cell lung carcinoma (NSCLC) tumor xenografts. well tolerated not severe liver or common ocular toxicities reported for inhibitors. Transient diarrhea the...
Nocturnal nasal intermittent positive pressure ventilation (NIPPV) is increasingly used to treat chronic respiratory failure in a wide variety of conditions (myopathies, Ondine's curse, kyphoscoliosis, etc.) and allows normal everyday life. Some these diseases affect women childbearing age. We report on young woman suffering from primary alveolar hypoventilation, who presented with limitation daytime activities, severe oxygen desaturation during sleep, polycythaemia pulmonary hypertension....