A5084675557- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- Neuroblastoma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Complementary and Alternative Medicine Studies
- Colorectal Cancer Treatments and Studies
- Gastrointestinal motility and disorders
- DNA Repair Mechanisms
- Occupational and environmental lung diseases
- Biochemical Analysis and Sensing Techniques
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Olfactory and Sensory Function Studies
- Regulation of Appetite and Obesity
- PARP inhibition in cancer therapy
- Testicular diseases and treatments
- Graphene and Nanomaterials Applications
- Herbal Medicine Research Studies
- Prostate Cancer Treatment and Research
- Brain Metastases and Treatment
- Multiple and Secondary Primary Cancers
- Advanced Breast Cancer Therapies
- Effects of Radiation Exposure
Oxford University Hospitals NHS Trust
2016-2024
Institute of Molecular Medicine
2008-2023
University of Oxford
2010-2021
National Health Service
2021
Churchill Hospital
2008-2021
Cancer Research UK Oxford Centre
2021
John Radcliffe Hospital
2010-2013
Molecular Oncology (United States)
2008
Queen Mary University of London
2002
St Bartholomew's Hospital
2001
No phase 3 trial has yet shown improved survival for patients with pleural or peritoneal malignant mesothelioma who have progressed following platinum-based chemotherapy. The aim of this study was to assess the efficacy and safety nivolumab, an anti-PD-1 antibody, in these patients.
Background & AimsThe pathogenesis of immune checkpoint inhibitor (ICI)–colitis remains incompletely understood. We sought to identify key cellular drivers ICI-colitis and their similarities idiopathic ulcerative colitis, determine potential novel therapeutic targets.MethodsWe used a cross-sectional approach study patients with ICI-colitis, those receiving ICI without the development healthy controls. A subset were studied longitudinally. applied range methods, including multiparameter...
Abstract The type 1 insulin-like growth factor receptor (IGF-1R) is a transmembrane glycoprotein composed of two extracellular α subunits and β with tyrosine kinase activity. IGF-1R frequently upregulated in cancers signals from the cell surface to promote proliferation survival. Recent attention has focused on as target for cancer treatment. Here, we report that nuclei human tumor cells contain IGF-1R, detectable using multiple antibodies α- β-subunit domains. Cell-surface translocates...
Abstract Background Immune checkpoint inhibitors (ICI) improve survival but cause immune-related adverse events (irAE). We sought to determine if CTCAE classification, IBD biomarkers/endoscopic/histological scores correlate with irAE colitis outcomes. Methods A dual-centre retrospective study was performed on patients receiving ICI for melanoma, NSCLC or urothelial cancer from 2012 2018. Demographics, clinical data, endoscopies (reanalysed using Mayo/Ulcerative Colitis Endoscopic Index of...
Importance Arginine deprivation using ADI-PEG20 (pegargiminase) combined with chemotherapy is untested in a randomized study among patients cancer. ATOMIC-Meso (ADI-PEG20 Targeting of Malignancies Induces Cytotoxicity-Mesothelioma) pivotal trial comparing standard first-line plus pegargiminase or placebo nonepithelioid pleural mesothelioma. Objective To determine the effect pegargiminase-based on survival mesothelioma, an arginine-auxotrophic tumor. Design, Setting, and Participants This was...
BackgroundComplementary and alternative medicine (CAM) is used increasingly by patients with chronic diseases. We have assessed the use of CAM in general gastrointestinal outpatients focusing particularly on factors predisposing to its inflammatory bowel disease (IBD).
Abstract Background: Arginine deprivation with ADI-PEG20 (pegargiminase) alone or combined chemotherapy displayed antitumor activity in early phase clinical trials of argininosuccinate synthase 1 (ASS1)-deficient cancers, including pleural mesothelioma (PM). The non-epithelioid subtype is particularly aggressive and arginine-auxotrophic due to frequent ASS1 loss. ATOMIC-meso a pivotal 2-3 trial comparing standard care (SOC) plus pegargiminase placebo for patients (pts) PM. Methods: In this...
Leptin is the protein product of obese gene, known to play an important role in body energy balance. The leptin receptor exists numerous isoforms, long isoform being major form involved signal transduction. expression has recently been demonstrated human pituitary, both normal tissue and pituitary adenomas. also shown be present adenomas; however, contrasting results have obtained regarding its pituitary.The aim this study was (i) investigate presence pattern distribution mRNA different...
A 60-year-old male was diagnosed with T3, N3, M1b epidermal growth factor receptor (EGFR) mutant lung adenocarcinoma. Five months later he developed significant headaches, weakness and numbness of the left leg, unsteadiness gait. Magnetic resonance imaging (MRI) brain demonstrated subtle gyral enhancement indicative early leptomeningeal infiltration. He commenced on second-line erlotinib which improved his lower limb symptoms. Three increased urinary frequency redeveloped leg MRI showed...
<div>Abstract<p>The type 1 insulin-like growth factor receptor (IGF-1R) is a transmembrane glycoprotein composed of two extracellular α subunits and β with tyrosine kinase activity. The IGF-1R frequently upregulated in cancers signals from the cell surface to promote proliferation survival. Recent attention has focused on as target for cancer treatment. Here, we report that nuclei human tumor cells contain IGF-1R, detectable using multiple antibodies α- β-subunit domains....
Supplementary Materials, Table 1-2, Figures 1-3 from Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells
<div>Abstract<p>The type 1 insulin-like growth factor receptor (IGF-1R) is a transmembrane glycoprotein composed of two extracellular α subunits and β with tyrosine kinase activity. The IGF-1R frequently upregulated in cancers signals from the cell surface to promote proliferation survival. Recent attention has focused on as target for cancer treatment. Here, we report that nuclei human tumor cells contain IGF-1R, detectable using multiple antibodies α- β-subunit domains....
Supplementary Figures 4-7 from Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells
Supplementary Figures 4-7 from Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells
Supplementary Materials, Table 1-2, Figures 1-3 from Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells