A5019103500- Toxic Organic Pollutants Impact
- Pesticide Exposure and Toxicity
- Heavy Metal Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Trace Elements in Health
- SARS-CoV-2 and COVID-19 Research
- Chronic Kidney Disease and Diabetes
- Pesticide and Herbicide Environmental Studies
- COVID-19 Clinical Research Studies
- Paraquat toxicity studies and treatments
- Effects and risks of endocrine disrupting chemicals
- Poisoning and overdose treatments
- Vaccine Coverage and Hesitancy
- Acute Kidney Injury Research
- Heavy metals in environment
- Bipolar Disorder and Treatment
- Liver Disease and Transplantation
- Weed Control and Herbicide Applications
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Clay minerals and soil interactions
- Sepsis Diagnosis and Treatment
- Diabetes Treatment and Management
- Aluminum toxicity and tolerance in plants and animals
Kaohsiung Chang Gung Memorial Hospital
2016-2025
Chang Gung University
2018-2025
Kaohsiung Medical University
2024
National Cheng Kung University
2019
University of Florida
2019
Columbus Oncology and Hematology Associates
2019
Organophosphate flame retardants (OPFRs) are emerging and widespread environmental pollutants with potential health hazards, including nephrotoxicity. However, the exposure patterns nephrotoxic of OPFRs yet to be investigated in patients chronic kidney disease (CKD). We conducted a cross-sectional study involving 166 CKD stratified by estimated glomerular filtration rate (eGFR) severity proteinuria. The urinary concentrations 10 OPFR compounds were measured evaluate patterns. Clinical...
Chronic nickel accumulation is harmful to multiple organ systems, and classified as a human carcinogen. Nevertheless, few studies have examined serum concentrations in end-stage kidney disease (ESKD) patients receiving chronic hemodialysis, the relationship of with clinical outcomes remains unclear. This prospective observational study recruited 409 hemodialysis 2019 followed them for 18 months. The were stratified into four quartiles, that is, < 2.9 μg/L (n = 92), 3.4 g/L 104), 3.9 ≥ 109),...
Molnupiravir is an essential oral antiviral agent against coronavirus disease 2019 (COVID-19); however, its real-world effectiveness has not been evaluated in patients undergoing haemodialysis (HD).This multi-centre retrospective study, involving 225 HD with initially mild or asymptomatic COVID-19, was conducted to compare the risks of 30-day COVID-19-related acute care visits between receiving and molnupiravir. Patients who received molnupiravir were stratified by rapid antigen detection...
There is an overall paucity of data regarding the human toxicity chlorpyrifos and cypermethrin pesticide mixture. Both organophosphate pyrethroid insecticides are metabolized by carboxylesterases. Thus, its combination, organophosphates may boost pyrethroids via inhibited detoxification This study examined clinical course, laboratory tests, outcomes patients with chlorpyrifos, or their mixture poisoning, to determine what association, if any, might exist between these findings.Between 2000...
Organophosphate flame retardants (OPFRs) are emerging environmental pollutants that can be detected in water, dust, and biological organisms. Certain OPFRs disrupt lipid metabolism animal models cell lines. However, the effects of on human remain unclear. We included 1,580 participants (≥20 years) from 2013–2014 National Health Nutrition Examination Survey (NHANES) to explore relationship between OPFR exposure biomarkers. After adjusting for confounding factors, results showed one-unit...
Cadmium exposure is associated with chronic kidney disease (CKD), but the optimal biomarker for early cadmium-associated nephrotoxicity in low-level has not yet been established. We conducted a cross-sectional investigation involving 167 CKD patients stratified according to tertiles of urinary cadmium levels (UCd), which enzyme-linked immunosorbent assay (ELISA)-measured novel renal biomarkers were utilized assess extent injury burden. In analyses, molecule-1 (KIM-1) and age independent...
Low-level cadmium exposure has adverse effects on chronic kidney disease (CKD); however, the risk factors for elevated blood levels (BCLs) have not been studied in CKD. We conducted a cross-sectional investigation 200 CKD patients and stratified them by tertiles of BCL to compare their demographic, environmental, biochemical data. The associated with were identified, examined subgroups. In analyses, female sex, smoking, stage 5D high BCL, statin was inversely correlated (odds ratio [95%...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine booster is one of the most essential strategies against disease 2019 (COVID-19) in era emerging variants. However, effectiveness SARS-CoV-2 boosters has not much been investigated hemodialysis (HD) patients receiving oral antiviral agents. In this retrospective study involving 258 HD with COVID-19 molnupiravir, we stratified cohort according to vaccination status and compared baseline characteristics risks 30-day...
There is limited literature analyzing the outcome of human poisoning with methomyl and cypermethrin pesticide mixture. Between 2002 2018, a total 63 patients intoxicated methomyl, cypermethrin, or their mixture were treated at Chang Gung Memorial Hospital. The categorized into three groups based on type pesticide, as (n = 10), 31), 22). Demographic, clinical, laboratory, mortality data obtained for analysis. aged 54.9 ± 18.9 years. Following ingestion, experienced wide range clinical...
Summary Q fever (QF) is a worldwide zoonosis associated with outbreaks. Only few nationwide studies regarding the surveillance and epidemiology of human QF have been reported. Although endemic in Taiwan, database investigation characteristics its associations scrub typhus (ST), murine (MT) leptospirosis (LS) has never We analysed databases suspected QF, ST, MT LS cases from October 2007 to December 2014 obtained Centers for Disease Control, Taiwan. A total 468 (4.2%) were identified among 11...
Organophosphate flame retardants (OPFRs) are ubiquitous in the environment. The compositions and concentrations of different OPFRs metabolites vary environments depending on human activities. objective present study was to evaluate exposure age groups Taiwan.Volunteers provided urine samples responded questionnaires including demographic factors, underlying disease, lifestyle information, occupation from October 2021 January 2022. OPFR measurements were performed using a Waters Acquity...
Background. This retrospective observational study attempted to examine the prevalence of abnormal blood aluminum levels in dialysis patients, and explore association pathogenic factors, such as demographic, clinical, laboratory well use phosphate binding drugs, drugs for secondary hyperparathyroidism erythropoiesis-stimulating with levels. Methods. The included 1175 patients (874 hemodialysis 301 peritoneal dialysis), recruited from Chang Gung Memorial Hospital November 2020. Patients were...
Background Organophosphate flame retardants (OPFRs) are widely distributed in the environment and their metabolites observed urine, but little is known regarding OPFRs a broad-spectrum young population from newborns to those aged 18 years. Objectives Investigate urinary levels of OPFR Taiwanese infants, children, schoolchildren, adolescents within general population. Methods Different age groups subjects (n=136) were recruited southern Taiwan detect 10 urine samples. Associations between...
Acute kidney disease (AKD) forms part of the continuum acute injury (AKI) and worsens clinical outcomes. Currently, predictors AKD severity have yet to be established. We conducted a retrospective investigation involving 310 hospitalized patients with AKI stratified them based on stages defined by Dialysis Quality Initiative criteria. Demographic, clinical, hematologic, biochemical profiles, as well 30-day outcomes, were compared between subgroups. In analysis, use offending drugs (odds...
Hemodialysis is often recommended to treat severe lithium poisoning. Nevertheless, the application rate of hemodialysis in patients with poisoning varied across different groups and effect still undetermined. Therefore, this study aimed analyze explore clinical features lithium-poisoned-patients treated or untreated hemodialysis.Between 2001 2019, 36 at Chang Gung Memorial Hospital for management were stratified according whether they (n = 7) not 29).The aged 50.7 ± 18.1 years. The patterns...
Abstract Background and Aims Organophosphate flame retardants (OPFRs) are widely utilized considered less harmful than legacy brominated retardants. However, owing to their widespread utilization, OPFRs have led extensive persistent human exposure, with potentially hazardous effects on health such as nephrotoxicity. Experimental clinical studies revealed that OPFR exposure is associated renal tubular toxicity impairment. the nephrotoxic mechanisms of not yet been clarified, impact injury has...
Abstract Mammalian targets of rapamycin inhibitors (mTORIs), including sirolimus and everolimus, are used for minimizing calcineurin after liver transplantation. However, head‐to‐head randomized comparisons these 2 mTORIs lacking. We assessed the differences in renoprotection possible mechanisms between everolimus transplant recipients. For this prospective cohort study, we recruited recipients whose regimens were switched from tacrolimus to or at a Taiwan medical center. Serial changes...
Hemodialysis (HD) patients are vulnerable to coronavirus disease 2019 (COVID-19) and have a high mortality rate. We evaluated the anti-SARS-CoV-2 spike protein antibody (ACOV2S) levels in 385 HD before 4 8 weeks after second dose of vector-based ChAdOx1 nCoV-19 vaccine. For study control, week ACOV2S vaccination were measured 66 healthcare workers (HCWs). The seroconversion rate was 98.96% vaccination. Despite low (week 0), vaccine increased prominently compatible with those HCWs (p = 0.814...
Patients undergoing cardiac catheterization are at high risk of post-procedure acute kidney injury (AKI) and may experience persistent renal damage after an initial insult, a state known as disease (AKD). However, the association between AKD urinary biomarkers has not yet been evaluated in this population. We enrolled 94 patients who underwent elective to investigate patterns their associations with AKD. Serial biomarker levels were measured during pre-procedure, early (12–24 h), late (7–10...
Humans are extensively exposed to organophosphate flame retardants (OPFRs), an emerging group of organic contaminants with potential nephrotoxicity. Nevertheless, the estimated daily intake (EDI) and prognostic impacts OPFRs have not been assessed in individuals chronic kidney disease (CKD). In this 2-year longitudinal study 169 patients CKD, we calculated EDIs five OPFR triesters from urinary biomonitoring data their degradation products analyzed effects exposure on adverse renal outcomes...
Introduction The toxicity and carcinogenicity of glyphosate have long been debated. Nevertheless, the mortality rate in patients with acute glyphosate-surfactant poisoning varies across different groups. Methods Between 2002 2020, 109 received treatment at Chang Gung Memorial Hospital. Patients were stratified into two subgroups according to their prognosis: good ( n = 74) or poor 35). Baseline demographics, psychiatric comorbidities, medical complications, laboratory data collected,...
Abstract Background and Aims Environmental factors account for the majority of identified risks associated with CKD uncertain etiology (CKDu). Among various environmental factors, plasticizer di(2-ethylhexyl) phthalate (DEHP) is widely used in modern life. The exposure to DEHP extensive but mostly underestimated general population. link between renal injuries has been scarcely reported underlying mechanisms are largely unknown. This study aimed examine by which causes tubular injuries....