A5015788357- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Cervical Cancer and HPV Research
- Global Maternal and Child Health
- Parasites and Host Interactions
- HIV Research and Treatment
- Child Nutrition and Water Access
- Insects and Parasite Interactions
- Respiratory and Cough-Related Research
- Antifungal resistance and susceptibility
- Delphi Technique in Research
- Monoclonal and Polyclonal Antibodies Research
- Insect Utilization and Effects
- Vaccine Coverage and Hesitancy
- Hepatitis B Virus Studies
- Immunodeficiency and Autoimmune Disorders
- HIV/AIDS Research and Interventions
- Inhalation and Respiratory Drug Delivery
- Mast cells and histamine
- Contact Dermatitis and Allergies
- Fungal Infections and Studies
- Eosinophilic Esophagitis
- Air Quality and Health Impacts
- Health Literacy and Information Accessibility
National University of Science and Technology
2019-2025
Mpilo Central Hospital
2025
Horiba (United Kingdom)
2024
University of Edinburgh
2018-2024
Medical University of Vienna
2015-2021
Atlanta Allergy and Asthma Clinic
2019-2020
National Blood Service Zimbabwe
2020
Parirenyatwa Hospital
2015
University Teaching Hospital
2015
University of Zimbabwe
1995-2015
The prevalence of allergic airway diseases such as asthma and rhinitis has increased dramatically to epidemic proportions worldwide. Besides air pollution from industry derived emissions motor vehicles, the rising trend can only be explained by gross changes in environments where we live. world economy been transformed over last 25 years with developing countries being at core these changes. Around planet, both developed countries, are undergoing profound Many considered have negative...
Introduction The increasing prevalence of allergic diseases in Zimbabwe may be attributed to changing environmental exposure patterns. In this study, we sought identify the most influential and lifestyle factors that explain observed atopy a rural community Zimbabwe. Methods Using cross-sectional information on wide array exposures was self-reported by sample participants (children aged <18 years adults ≥18 years) Gwanda district, To consenting participants, performed skin prick...
The purpose of our prospective, case-controlled study was to investigate the hypothesis that women who are genetically programmed produce high or medium levels IL-10 were more likely develop cancer uterine cervix than individuals predisposed low production. population recruited from patients attending gynecological clinics at 2 hospitals in Harare, Zimbabwe. Laboratory tests performed Departments Immunology, Chemical Pathology and Medical Microbiology, School, University Zimbabwe,...
Objectives: Postpartum depression is a common and serious mental health problem which associated with maternal distress negative consequences for the offspring. Research confirms presence of differences in prevalence postpartum different social groups. The aim this study was to compare severity symptoms Poland Zimbabwe identify risk factors occurring both Material methods: survey conducted 2022 among mothers who gave birth at Department Neonatology Rare Diseases Mpilo Central Hospital...
Infectious diseases remain a major health and socioeconomic problem in many low-income countries, particularly sub-Saharan Africa. For years, the three most devastating diseases, HIV/AIDS, malaria, tuberculosis (TB) have received of world's attention. However, rural impoverished urban areas, number infectious neglected cause massive suffering. It has been calculated that group 13 affects over one billion people, corresponding to sixth population. These include infections with different types...
The purpose of the study was to investigate hypothesis that genetically programmed ability produce low, medium, or high levels tumor necrosis factor-alpha (TNF-alpha), as determined by TNF-alpha promoter polymorphism at position 308, influenced development cancer uterine cervix. population recruited from patients attending gynecological clinics two teaching hospitals in Harare, Zimbabwe. Laboratory tests were performed Departments Immunology and Medical Microbiology, School, University One...
The 2012 Global Lung Function Initiative (GLI2012) provide multi-ethnic spirometric reference equations (SRE) for the 3-95 year-old age range, but Sub-Saharan African populations are not represented. This study aimed to evaluate fit of African-American GLI2012 SRE a population healthy urban and peri-urban Zimbabwean school-going children (7-13 years).Spirometry anthropometry were performed on black-Zimbabwean recruited from three primary schools in Harare, with informed consent assent....
Background In order to protect health workers from SARS-CoV-2, there is need characterise the different types of patient facing workers. Our first aim was determine both infection status and seroprevalence SARS-CoV-2 in second evaluate occupational demographic predictors seropositivity inform country’s prevention control (IPC) strategy. Methods principal findings We invited 713 staff members at 24 out 35 facilities City Bulawayo Zimbabwe. Compliance testing defined as willingness uptake...
The prevalence of allergic diseases has been increasing continuously and, accordingly, there is a great desire to evaluate the allergenic potential components in our daily environment (e.g., food). Although almost no scientific evidence that genetically modified organisms (GMOs) exhibit increased allergenicity compared with corresponding wild type significant concerns have raised regarding this matter. In principle, it possible GMOs may be due introduction foreign allergens, potentially...
In Africa, peanuts are frequently consumed, but severe allergic reactions rare. We investigated immunological patterns of clinical tolerance to peanut in peanut-sensitized asymptomatic patients from central Africa compared peanut-allergic and Sweden.Sera (n = 54) Zimbabwe sensitized without symptoms peanut, sera 25) Sweden were analyzed toward allergen components (Ara h 1-3, 6, 8-9) other molecules important sources using microarray. IgE Ara 2 peptide epitopes was analyzed, allergenic...
Zimbabwe currently faces several healthcare challenges, most notably HIV and associated infections including tuberculosis (TB), malaria recently outbreaks of cholera, typhoid fever COVID-19. Fungal infections, which are also a major public health threat, receive considerably less attention. Consequently, there is dearth data regarding the burden fungal diseases in country. We estimated based on published literature 'at-risk' populations (HIV/AIDS patients, survivors pulmonary TB, cancer,...
Background Fungal lung diseases are global in distribution and require specific tests for diagnosis. We report a survey of diagnostic service provision Africa. Methods A written questionnaire was followed by video conference call with each respondent(s) external validation. To disseminate the questionnaire, snowball sample used. Results Data were successfully collected from 50 51 African countries populations >1 million. The completed respondents affiliated 72 health facilities. Of these...
Abstract Despite the high prevalence of both human papillomavirus (HPV) infections and cervical cancer among Zimbabwean women, ability to test for HPV infection uterine cervix is limited by a lack an easy sample collection method that does not require gynecological examination. The presence HPVs in urine swab samples collected from 43 women who presented with invasive was investigated. detection done means degenerate primers nested polymerase chain reaction (PCR). Typing using restriction...
Background. Cervical cancer affects 1 in 2000 Zimbabwean women. We investigated the type‐specific distribution of human papillomavirus (HPV) infection women with invasive cervical cancer. Methods. conducted a descriptive study on 98 The methods used were nested polymerase chain reaction (PCR) for amplification HPV‐DNA and restriction fragment length polymorphism (RFLP) to characterize HPV types. Results. was identified 97% cases. types 16, 33, 18 31 61%, 39%, 18% 4% patients, respectively....
The infection of CD4+ cells by HIV leads to the progressive destruction T lymphocytes and, after a severe reduction cells, AIDS. aim study was investigate whether HIV-infected patients with CD4 cell counts <200 cells/µl can suffer from symptoms IgE-mediated allergy, produce allergen-specific IgE antibody responses and show boosts production. ≤200 suffering AIDS allergy were studied. Allergy diagnosed according case history, physical examination, skin prick testing (SPT), serological analyses...
Summary Transforming growth factor‐beta 1 (TGF‐β1) has a multifactorial role in the development of cervical cancer. It potently inhibits epithelial cells that harbour oncogenic human papilloma viruses (HPVs). TGF‐β1 also expression early viral transforming regions E6 and E7, which appear to be key oncoproteins. been suggested squamous cell carcinomas are devoid TGF‐β1, raising possibility elevated levels this factor could protect against is recognized production genetically predetermined...
HIV microarray for the simultaneous measurement of antibodies towards a comprehensive set HIV-derived peptides and proteins.
A comprehensive set of recombinant proteins and peptides the proteome HIV-1 clade C was prepared purified used to measure IgG, IgG-subclass, IgA IgM responses in HIV-infected patients from Sub-Saharan Africa, where is predominant. As a comparison group, Europe were tested. African European showed an almost identical antibody reactivity profile terms epitope specificity involvement IgG subclass, responses. V3-peptide gp120 identified as major recognized by IgG1>IgG2 = IgG4>IgG3, IgA>IgM...