A5103270626- Ion channel regulation and function
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Knee injuries and reconstruction techniques
- Animal Virus Infections Studies
- Osteoarthritis Treatment and Mechanisms
- SARS-CoV-2 detection and testing
- Lower Extremity Biomechanics and Pathologies
- vaccines and immunoinformatics approaches
Neurocrine Biosciences (United States)
2023-2024
Centre for Immunity, Infection and Evolution
2021
University of Edinburgh
2021
University of Nottingham
2009
University of Southampton
2009
Queen's Medical Centre
2009
Glasgow Life
2009
University of South Australia
2009
Voltage-gated sodium channel (NaV) inhibitors are used to treat neurological disorders of hyperexcitability such as epilepsy. These drugs act by attenuating neuronal action potential firing reduce excitability in the brain. However, all currently available NaV-targeting antiseizure medications nonselectively inhibit brain channels NaV1.1, NaV1.2, and NaV1.6, which potentially limits efficacy therapeutic safety margins these drugs. Here, we report on XPC-7724 XPC-5462, represent a new class...
Objective . To describe the association between sex, age and rate of change in knee cartilage volume adults. Methods A total 325 subjects (mean 45 yrs, range 26–61) was measured at baseline ∼2 yrs later. Knee bone size were determined using T1-weighted fat saturation magnetic resonance imaging (MRI). Height, weight, body mass index radiographic osteoarthritis (ROA) by standard protocols. Results decreased 1.5–4.2% per annum. In multivariable analysis, females had higher rates annum than...
Background In order to protect health workers from SARS-CoV-2, there is need characterise the different types of patient facing workers. Our first aim was determine both infection status and seroprevalence SARS-CoV-2 in second evaluate occupational demographic predictors seropositivity inform country’s prevention control (IPC) strategy. Methods principal findings We invited 713 staff members at 24 out 35 facilities City Bulawayo Zimbabwe. Compliance testing defined as willingness uptake...
Abstract Inhibitors of voltage-gated sodium channels (Na V s) are important anti-epileptic drugs, but the contribution specific channel isoforms is unknown since available inhibitors nonselective. We created a series compounds with diverse selectivity profiles enabling block Na 1.6 alone or together 1.2. Mice heterozygous gain-of-function mutation (N1768D/+) in Scn8a (encoding 1.6) responded tonic-clonic seizure to mild 6 Hz stimulus that was innocuous wild-type mice. Pharmacologic...
Abstract Sodium channel inhibitors are used to treat neurological disorders of hyperexcitability. However, all currently available sodium targeting anti-seizure medications non-selective among the Na V isoforms which potentially limits efficacy and therapeutic safety margins. XPC-7724 XPC-5462 represent a new class small molecule compounds. These compounds target inhibition 1.6 1.2 channels in excitatory pyramidal neurons possess molecular selectivity >100 fold against 1.1 that dominant...
Background: The novel Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) pandemic in Africa has differed from that other continents. Explanations proposed for this have included previous exposure to pathogens may induce protective cross-immunity or modify the immune phenotype. Methods: Initially, we determined prevalence of SARS-CoV-2 serological cross reactivity pre-pandemic sera 340 Zimbabweans aged 1-88 using a commercial rapid lateral flow test. We subsequently screened...