The optimal route of estrogen replacement in Turner syndrome (TS) is unknown.The objective the study was to compare conjugated oral vs. transdermal (TD E2) on bone accrual, uterine growth, pubertal development, IGF-I, and lipids girls with TS.Prepubertal GH-treated aged 10 yr or older TS were eligible. Subjects randomized TD E2 for 1 yr. Assessments included dual-emission x-ray absorptiometry, pelvic ultrasound, Tanner staging, growth velocity, lipid profile.Twelve (14.0 +/- 1.7 yr)...

To compare glycemic control, body mass index (BMI), neurocognitive function, and parenting stress for preschool-aged diabetic children randomized to treatment either with continuous subcutaneous insulin infusion (CSII) or intensive injection therapy (IIT).Children <5 yr of age diagnosed type 1 diabetes mellitus at least 12 months were CSII (n = 21) IIT 6 months. After months, the group began continued on pumps. Hemoglobin A1c (HbA1c) BMI percent collected baseline, 3, 6, 9, Neurocognitive...

Objectives To increase diversity and inclusion in graduate medical education (GME), the Accreditation Council for Graduate Medical Education (ACGME) issued new standards requiring programs to engage practices that focus on systematic recruitment retention of a diverse workforce trainees faculty. The literature how program directors (PDs) can incorporate prepare this standard is limited. Methods We developed diversity, equity, (DEI) toolkit PDs as an example institutional GME-led effort...

Little is known about the comparative effects of different glucocorticoids on adrenal and growth hormone (GH) axes in children with congenital hyperplasia (CAH). We sought to compare hydrocortisone (HC), prednisone (PDN), dexamethasone (DEX) classic CAH investigate a potential role pharmacogenetics. Subjects were randomly assigned three sequential 6-week courses HC, PDN, DEX, each followed by evaluation hormones, IGF-1, GH, body mass index (BMI). Single nucleotide polymorphism (SNP) analysis...

The objective of this study was to determine the incidence, specific abnormalities, and clinical significance upper-tract genitourinary malformations in girls with congenital adrenal hyperplasia.Medical charts children who received a diagnosis hyperplasia between 1985 2005 were reviewed.Of 107 patients hyperplasia, 66 identified. Of these, 14 found have abnormalities. anomalies consisted vesicoureteral reflux grades 1 3 (9), hydronephrosis (4), duplicated collecting system (1). Two boys...

OBJECTIVE A diverse physician workforce ensures equitable care. The holistic review of residency applications is one strategy to enhance diversity; however, little known about current adoption and the factors that facilitate/impede recruitment practices (HRPs) by graduate medical education (GME) residency, fellowship program directors (PDs). To describe state explore, barriers/facilitators HRPs at our institution. METHODS We disseminated information HRP within between 2021 2022. In May 2022,...

To investigate the incidence of urinary tract infections (UTIs) in children with congenital adrenal hyperplasia (CAH), and to determine whether there was a correlation between UTIs timing type genital surgery girls.Medical records patients CAH < or = 15 years were reviewed. A parent questionnaire regarding history completed.Seventy-one classic (41 girls, 30 boys) aged 8.3 +/- 4.2 identified. Thirty-five (85%) girls had undergone feminizing genitoplasty at 1.1 0.8 years, while six (15%) not....

Issue: Resident teachers play an essential role in medical education and can support broader efforts to advance anti-racism health equity medicine. The Accreditation Council for Graduate Medical Education requires programs provide about care disparities so residents contribute lead work this area. However, the literature includes few examples, frameworks, or strategies preparing develop knowledge skills needed promote equity, including their as clinical teachers. Evidence: In article,...

Article Normal Adult Height Among Girls Treated for Central Precocious Puberty with Gonadotropin-Releasing Hormone Analog Therapy was published on April 1, 2009 in the journal Journal of Pediatric Endocrinology and Metabolism (volume 22, issue 4).

Efforts toward achieving diversity, equity, inclusion, and justice (DEIJ) within graduate medical education (GME) often begin with the formation of a DEIJ committee that steers work. Little is known about experiences challenges faced by those serving on such committees. We sought to describe members our institutional GME gain knowledge would propel this work forward. An open-ended survey was electronically administered committee. Responses were analyzed using rapid qualitative analytical...

Problem: Learner mistreatment has remained an ongoing challenge in academic medicine despite accreditation requirements mandating that every program systems place to prevent and respond mistreatment. While efforts vary across institutions, much remains unanswered the literature about best practices. Additionally, for foreseeable future, challenges learning environment will likely continue potentially worsen, given confluence of multiple external stressors including COVID-19 pandemic, faculty...

Monozygotic twins with Turner syndrome have rarely been reported. An increased incidence of slipped capital femoral epiphysis has associated growth hormone therapy, as well syndrome, but never described in syndrome. We report the first case monozygotic a 46,Xi(Xq) karyotype, both whom developed during therapy. This adds to existing reports and contributes recognition potential clinical course such patients. In addition, association between epiphysis, is emphasized.

To describe an unusual case of familial male precocious puberty (FMPP) characterized by periodic remission compared to a series boys with typical testotoxicosis.Medical records FMPP followed at our institution from 2001-2017 were reviewed. Variables analyzed included age, family history, physical exam, hormone levels, bone and treatment.A boy age 2 years 10 months presented growth acceleration masturbatory behaviors. On he had 6-mL testes, enlarged phallus (10.5 × 2.5 cm), Tanner pubic hair....

Short stature is a common reason for referral to the pediatric endocrine clinic. In 2003, US Food and Drug Administration (FDA) approved use of growth hormone (GH) treatment children with idiopathic short (ISS).To explore if this indication changed referrals (SS).A retrospective chart review seen SS in clinic between July 1998 June 1999 (interval one, n=138) 2005-June 2006 two, n=268) was performed. Variables collected included age, gender, height (h), parental heights.Average standard...