A5050462939- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Cancer Immunotherapy and Biomarkers
- Complement system in diseases
- T-cell and B-cell Immunology
- Medical Imaging and Pathology Studies
- Glycosylation and Glycoproteins Research
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Blood transfusion and management
- Lung Cancer Diagnosis and Treatment
- Hepatitis B Virus Studies
Columbia University
2024
Columbia University Irving Medical Center
2022-2023
Although red blood cell (RBC) transfusions save lives, some patients develop clinically-significant alloantibodies against donor group antigens, which then have adverse effects in multiple clinical settings. Few effective measures exist to prevent RBC alloimmunization and/or eliminate sensitized patients. Donor-related factors may influence alloimmunization; thus, there is an unmet need identify units are immunogenic. Repeat volunteer donors and on iron supplements elevated reticulocyte...
Although red blood cell (RBC) transfusions save lives, some patients develop clinically-significant alloantibodies against donor group antigens, which then have adverse effects in multiple clinical settings. Few effective measures exist to prevent RBC alloimmunization and/or eliminate sensitized patients. Donor-related factors may influence alloimmunization; thus, there is an unmet need identify units are immunogenic. Repeat volunteer donors and on iron supplements elevated reticulocyte...
Passive immunization with anti-D can prevent maternal alloimmunization to RhD thereby preventing hemolytic disease of the fetus and newborn. Unexpectedly, fails in some cases monoclonal preparations paradoxically enhances alloimmunization. The underlying mechanisms modulating humoral by are unknown. We previously reported that IgG antibody subclasses differentially regulate alloimmunity response red blood cell (RBC) transfusions a mouse model; particular, IgG2c significantly enhanced RBC...
Failure of immune tolerance can lead to autoantibody production resulting in autoimmune diseases, a broad spectrum organ-specific or systemic disorders. Immune mechanisms regulate autoreactive T and B cells, yet some lymphocytes escape promote production. CD4+ cell dysregulation, characterized by decreased impaired regulatory cells (Tregs) and/or accumulation memory effector such as TH17, plays crucial role the pathogenesis these diseases. Antinuclear antibody (ANAs) testing is used first...
Autoimmune hemolytic anemia (AIHA), due to pathogenic autoantibodies that destroy red blood cells (RBCs), is a severe, and sometimes fatal, disease. The incidence of AIHA secondary immune checkpoint inhibitor immunotherapy (ICPi) increasing; indeed, it the most frequent hematological adverse event ICPi associated with severe hemolysis high fatality rates. Because current therapies for have variable success, relapse rates, there an unmet need develop more efficacious treatments. In mouse...