A5101427176- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Wood Treatment and Properties
- Tree Root and Stability Studies
- Sports injuries and prevention
- vaccines and immunoinformatics approaches
- Diagnosis and treatment of tuberculosis
- Atherosclerosis and Cardiovascular Diseases
- Immune Response and Inflammation
- Microbial Community Ecology and Physiology
- Forest ecology and management
- Monoclonal and Polyclonal Antibodies Research
- Sports Performance and Training
- Shoulder Injury and Treatment
- Genomics and Phylogenetic Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Handwritten Text Recognition Techniques
- Microbial bioremediation and biosurfactants
- Biochemical and Molecular Research
- Axon Guidance and Neuronal Signaling
- Plant Genetic and Mutation Studies
- Bamboo properties and applications
- Single-cell and spatial transcriptomics
- MicroRNA in disease regulation
- Ovarian cancer diagnosis and treatment
Aligarh Muslim University
2009-2025
University of Delhi
2016-2025
Panjab University
2024
New York University
2018-2024
Junagadh Agricultural University
2024
Fruit Research Institute
2024
Guru Nanak Dev University
2022-2024
University of Jammu
2024
National Institute of Technical Teachers Training and Research
2024
Swami Vivekanand Subharti University
2024
Rationale: Regression of atherosclerosis is an important clinical goal; however, the pathways that mediate resolution atherosclerotic inflammation and reversal plaques are poorly understood. Regulatory T cells (Tregs) have been shown to be atheroprotective, yet numbers these immunosuppressive decrease with disease progression, whether they contribute regression not known. Objective: We investigated roles Tregs in inflammation, tissue remodeling, plaque contraction during regression. Methods...
Abstract Obesity can lead to type 2 diabetes and is an epidemic. A major contributor its adverse effects inflammation of the visceral adipose tissue (VAT). Life-long caloric restriction (CR), in contrast, results extended lifespan, enhanced glucose tolerance/insulin sensitivity, other favorable phenotypes. The CR following obesity are incompletely established, but studies show multiple benefits. Many leukocyte types, macrophages predominantly, reside VAT homeostatic pathological states....
During obesity, macrophages infiltrate the visceral adipose tissue and promote inflammation that contributes to type II diabetes. Evidence suggests rewiring of cellular metabolism can regulate macrophage function. However, metabolic programs characterize (ATM) in obesity are poorly defined. Here, we demonstrate ATM from obese mice exhibit profiles characterized by elevated glycolysis oxidative phosphorylation, distinct lean mice. Increased activation HIF-1α resulted induction IL-1β genes...
Rationale: MicroRNA-33 (miR-33 [post-transcriptionally in the rationale]) post-transcriptionally represses genes involved lipid metabolism and energy homeostasis. Targeted inhibition of miR-33 increases plasma HDL (high-density lipoprotein) cholesterol promotes atherosclerosis regression, part, by enhancing reverse transport dampening plaque inflammation. However, how reshapes immune microenvironment plaques remains poorly understood. Objective: To define alters dynamic balance...
Macrophages accumulate prominently in the visceral adipose tissue (VAT) of obese humans and high fat diet (HFD) fed mice, this is linked to insulin resistance type II diabetes. While mechanisms regulating macrophage recruitment obesity have been delineated, signals directing persistence VAT are poorly understood. We previously showed that neuroimmune guidance cue netrin-1 expressed mice humans, where it promotes accumulation. To better understand source its effects on (ATM) fate function...
Rationale: Therapeutic efforts to decrease atherosclerotic cardiovascular disease risk have focused largely on reducing atherogenic lipoproteins, yet lipid-lowering therapies alone are insufficient fully regress plaque burden. We postulate that arterial repair requires resolution of a maladaptive immune response and targeting factors hinder inflammation will facilitate regression. Objective: The guidance molecule Ntn1 (netrin-1) is secreted by macrophages in plaques, where it sustains...
Background: India has one of the highest prevalence tuberculosis (TB) incidence, and Vitamin D deficiency is potentially a risk factor. Latent TB infection main reservoir global burden TB. Detecting Mycobacterium identifying factors are first steps toward improving control, preventive therapy, treatment completion. Methods: The present study explores relationship between latent by QuantiFERON-TB Gold PLUS using interferon-gamma release assay (IGRA) levels enzyme immunoassay in 46 young...
Recent report from our laboratory showed that A549 cells representing alveolar epithelial produce chemokine interleukin‐8 and nitric oxide (NO) when challenged with Mycobacterium tuberculosis . Interferon‐ γ (IFN‐ ) played a critical role in priming these to generate NO vitro In the present study, we M. ‐infected are capable of elaborating IFN‐ as shown by enzyme‐linked immunosorbent assay intracellular staining for Secretion profile indicated released significantly high concentration at 48...
Abstract Background The mce4 operon is one of the four homologues mammalian cell entry ( mce ) operons Mycobacterium tuberculosis . mce4A (Rv3499c) gene within this homologous to mce1A (Rv0169), that has a role in host invasion by M. Our earlier reports show expressed during stationary phase growth bacillus culture and course infection hosts. carrying mutation shows defect reduced survival infected mice. However, intracellular localization Mce4A protein its direct or not been demonstrated so...
The transformation processes of hexachlorocyclohexane isomers (HCHs) from production sites Lindane across the landscape and along food web were studied as an example to understand fate POPs in environment. Therefore, we concentration isotope composition HCHs different matrices vicinity a dumpsite chemical plant producing India. Carbon compositions (δ13C) enantiomer fraction (EF) α-HCH used indicators characterize situ degradation soil, groundwater, sediment well web. detected plants growing...
Summary In view of the presence a large number epithelial cells in alveoli lung and their ability to produce various cytokines chemokines, possible role alveolar innate immune response tuberculosis was examined. The human cell line A549 used as model. induce nitric oxide (NO) Mycobacterium infection taken an vitro correlate immunity. M. induced significant levels NO express inducible synthase mRNA at 48 hr infection. However, amount released this point not mycobactericidal. Cytokine...