A5090935213- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Medicinal Plants and Neuroprotection
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Cancer-related cognitive impairment studies
- Neuroscience and Neuropharmacology Research
- Systemic Lupus Erythematosus Research
- Electromagnetic Fields and Biological Effects
- Brain Metastases and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Tissue Engineering and Regenerative Medicine
- Silymarin and Mushroom Poisoning
- Bioactive Compounds and Antitumor Agents
- Nerve injury and regeneration
- Human Health and Disease
- Phosphodiesterase function and regulation
- Pharmacological Receptor Mechanisms and Effects
- Nicotinic Acetylcholine Receptors Study
- Psychological and Temporal Perspectives Research
- Chemical synthesis and alkaloids
- Pesticide Exposure and Toxicity
- Spaceflight effects on biology
Wayne State University
2024
University of California, Irvine
2024
Banaras Hindu University
2017-2023
Krishna Institute of Medical Sciences
2021
Babasaheb Bhimrao Ambedkar University
2014
University of Lucknow
2014
Alzheimer's disease (AD) is a neurodegenerative disorder with multifactorial pathogenesis. Monoamine oxidase (MAO) and acetylcholinesterase enzymes (AChE) are potential targets for the treatment of AD. A total 15 new propargyl containing 4,6-diphenylpyrimidine derivatives were synthesized screened MAO AChE inhibition activities along ROS production metal-chelation potential. All compounds found to be selective potent inhibitors MAO-A at nanomolar concentrations. VB1 was most BuChE inhibitor...
A series of 2-amino-5-nitrothiazole derived semicarbazones were designed, synthesised and investigated for MAO ChE inhibition properties. Most the compounds showed preferential towards MAO-B. Compound 4, (1-(1-(4-Bromophenyl)ethylidene)-4-(5-nitrothiazol-2-yl)semicarbazide) emerged as lead candidate (IC50 = 0.212 µM, SI 331.04) against MAO-B; whereas 21 1-(5-Bromo-2-oxoindolin-3-ylidene)-4-(5-nitrothiazol-2-yl)semicarbazide 0.264 µM) 17 1-((4-Chlorophenyl)...
Alzheimer's disease is considered one of the most prevalent neurodegenerative disorders and dementia core symptom this disease. This study was aimed to test bioactive compounds produced by endophytic fungus for inhibition acetylcholinesterase (AChE) activity identify compound responsible activity.Endophytic fungi were isolated from medicinal plant Tinospora cordifolia screened AChE antioxidant activity. The extract isolates Nigrospora oryzae (GL15) showed maximum as well (fraction 3)...
A series of novel benzimidazole-derived carbohydrazones was designed, synthesized and evaluated for their dual inhibition potential against monoamine oxidases (MAOs) acetylcholinesterase (AChE) using multitarget-directed ligand approach (MTDL). The investigated compounds have exhibited moderate to excellent
Aim: A breakthrough in modern medicine, terms of treatment Alzheimer's disease, is yet to be seen, as the scene currently plagued with numerous clinical trial failures. Here, we are exploring multifunctional hybrid sulfonamides for their anti-Alzheimer activity due complex nature disease. Results & methodology: Compound 41 showed significant inhibition MMP-2 (IC50: 18.24 ± 1.62 nM), AChE 4.28 0.15 μM) and BuChE 1.32 0.02 μM). It also exhibited a metal-chelating property, validated by an...
The aim of the present study was to in detail effect variable doses aspirin on intestinal toxicity.
D. montana (Roxb.) is a medicinal plant cultivated throughout Eastern Asia, comprises several biologically active compounds, such as steroids, naphthoquinones, polyphenols, and flavonoids. Earlier reports revealed that has been used for anti-inflammatory, antiviral, anticancer, inhibitor of prostaglandin synthesis, hypolipidemic, antileukemic agent. However, the anxiolytic activity yet not explained. Therefore, objective this study to investigate effect methanolic extract powder extracted...
Dynamin-1 (DNM1) consolidates memory through synaptic transmission and modulation has been explored as a therapeutic target in Alzheimer's disease. Through two-prong approach, this study examined its role cancer-related cognitive impairment (CRCI) pathogenesis using human animal models. The recruited newly diagnosed, chemotherapy-naïve adolescent young adult cancer non-cancer controls to complete instrument (FACT-Cog) blood draws for up three time points. Concurrently, syngeneic young-adult...
Purpose: The preventive and therapeutic potential of silibinin (SIL) was investigated in several experimental animal models gastric ulcer.Methods: effect SIL (50, 100 200 mg/kg) on rat lesion area pyloric ligation (PL), ethanol (EtOH) acetic acid (AA)-induced ulcer models. Further, secretion parameters, proton pump activity histamine content were estimated PL model. mucus antioxidant enzymatic activities evaluated EtOH subjected animals. Moreover, the histological architecture tissue AA...