A5014037084- Renal cell carcinoma treatment
- Renal and Vascular Pathologies
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Surgical Simulation and Training
- Prostate Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Ureteral procedures and complications
- Renal and related cancers
- Organ Donation and Transplantation
- Pelvic floor disorders treatments
- Minimally Invasive Surgical Techniques
- Urologic and reproductive health conditions
- Kidney Stones and Urolithiasis Treatments
- Urinary and Genital Oncology Studies
- Anatomy and Medical Technology
- Advanced X-ray and CT Imaging
- Cancer Genomics and Diagnostics
- Radiation Dose and Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- MRI in cancer diagnosis
- Anorectal Disease Treatments and Outcomes
- Diverticular Disease and Complications
- Pancreatic and Hepatic Oncology Research
Jacksonville College
2016-2025
Mayo Clinic in Florida
2016-2025
WinnMed
2015-2025
ATUM (United States)
2023
Menlo School
2023
Collaborative Research Group
2022
Nemours Children’s Clinic
2021
Mayo Clinic Hospital
2020
Nemours Children's Clinic
2005-2020
Jacksonville University
2011-2019
Early cancer detection could identify tumors at a time when outcomes are superior and treatment is less morbid. This prospective case-control sub-study (from NCT02889978 NCT03085888) assessed the performance of targeted methylation analysis circulating cell-free DNA (cfDNA) to detect localize multiple types across all stages high specificity.
In the Circulating Cell-free Genome Atlas (NCT02889978) substudy 1, we evaluate several approaches for a circulating cell-free DNA (cfDNA)-based multi-cancer early detection (MCED) test by defining clinical limit of (LOD) based on tumor allele fraction (cTAF), enabling performance comparisons. Among 10 machine-learning classifiers trained same samples and independently validated, when evaluated at 98% specificity, those using whole-genome (WG) methylation, single nucleotide variants with...
Planning complex operations such as robotic-assisted partial nephrectomy requires surgeons to review 2-dimensional computed tomography or magnetic resonance images understand 3-dimensional (3-D), patient-specific anatomy.To determine surgical outcomes for when reviewed 3-D virtual reality (VR) models during operative planning.A single-blind randomized clinical trial was performed. Ninety-two patients undergoing performed by 1 of 11 at 6 large teaching hospitals were prospectively enrolled...
Immune checkpoint inhibitors (ICI) are revolutionizing care for cancer patients. The list of malignancies which the Food and Drug Administration is granting approval rapidly increasing. Furthermore, there a concomitant increase in clinical trials incorporating ICI. However, safety ICI patients undergoing surgery remains unclear. Herein, we assessed perioperative setting at single center. We conducted retrospective review who underwent planned while receiving from 2012 to 2016. collected...
Purpose: Planning for robotic-assisted partial nephrectomy requires surgeons to review two-dimensional CT or MRI scans understand three-dimensional (3D) anatomy. We sought determine the drivers of improvements in key surgical outcomes when using patient-specific 3D virtual reality (VR) models operative planning. Materials and Methods: A multicenter, randomized, single-blind clinical trial was conducted from January 2019 December 2020. Patients undergoing were randomly assigned a control...
Dual-energy computed tomography (DECT) is an emerging imaging modality with the unique capability of determining urinary stone composition. This study compares radiation exposure DECT, standard single-energy CT (SECT), and low-dose renal protocol (LDSECT) for evaluation nephrolithiasis in a single vivo patient cohort.Following institutional review board (IRB) approval, we retrospectively reviewed 200 consecutive DECT examinations performed on patients suspected urolithiasis over 6-month...
INTRODUCTION: Robotic surgical technology has evolved to include a new platform specifically designed for the single-port (SP) approach. Benefits of da Vinci SP are still under investigation. This study aimed review urological literature since first report use platform.EVIDENCE ACQUISITION: We performed systematic PubMed, Medline, and Web Science databases on June 15, 2020 searching all available articles from December 2014 (date clinical in urology) until 1, following Preferred Reporting...
Venous thromboembolism (VTE) after urologic surgery occurs in about 1% of patients and is associated with peri-operative morbidity mortality. Given variability thromboprophylaxis practice, we aim to analyze the utilization Caprini risk-based prostatectomy nephrectomy. Cases were identified using medical record from large tertiary care centers United States. score was calculated retrospectively. Prophylaxis classified as either appropriate or inappropriate when comparing recommendations...
Abstract The mechanisms underlying metastatic latency in renal cell carcinoma (RCC) remain poorly understood. This study evaluated two large independent cohorts for differences tumor biology between patients who developed metastases early (≤1 year after nephrectomy) and those with late-onset (>3 years). In the discovery cohort (n = 161), late-metastatic RCC (late-mRCC) was associated clear histology (88.9% vs 78.7%), lower pathological stage (pT1-2; 40.3% 18.0%), favorable...
To analyze and compare the safety peri-operative outcomes of fellowship-trained robotic surgeons (FEL) experienced open (OE) incorporating robot-assisted laparoscopic prostatectomy (RALP) into practice.Multiinstitutional, prospective data were collected on first 30 RALP performed by FEL OE (defined as over 1000 prostatectomies) practice. Morbidity from course was evaluated operative outcomes. The second cases group to assess for improvement with experience.There no rectal injuries or death...
Abstract Background Cancer‐specific anxiety (CSA) can affect treatment decisions and is common in men following surgery for prostate cancer (PCa). We hypothesized that CSA also associated with factors affecting quality of life. Herein, we examine the association psychosocial PCa aggressiveness a cohort 1 year after prostatectomy localized PCa. Methods From our prospective Registry, identified 365 who underwent completed Memorial Anxiety Scale Prostate Cancer (MAX‐PC) Expanded Index Composite...
A current dilemma is how to incorporate robot assisted laparoscopic radical prostatectomy (RALP) into residency/fellowship programs while containing costs and maintaining acceptable operative times. We prospectively analyzed factors that affect the time of nine separate RALP steps performed in a training program incorporating da Vinci robot.A prospective evaluation 50 consecutive by single surgeon trainees was completed. divided segments, each segment recorded minutes. Who portion procedure...
It remains unclear whether the hemodilution effect of body mass index (BMI) on PSA levels translates to inappropriate prostate cancer (PCa) screening in obese men. To address this, we conducted two nested case–control studies within prospective cohorts men undergoing radical prostatectomy for newly diagnosed PCa. We identified 1817 with BMI ⩾30 kg m−2 (cases) and 1244 <25 (controls) who underwent surgery treat PCa at Mayo Clinic Rochester between 2000 2009. Cases controls were frequency...