A5103100121- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Viral-associated cancers and disorders
- Advanced Computational Techniques and Applications
- Molecular Biology Techniques and Applications
- Advanced Decision-Making Techniques
- Software Reliability and Analysis Research
- Power Systems and Technologies
- Data Management and Algorithms
- Evaluation Methods in Various Fields
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Geographic Information Systems Studies
- Insect symbiosis and bacterial influences
- Advanced Image and Video Retrieval Techniques
- Genomics and Rare Diseases
- Mosquito-borne diseases and control
- Genomics and Chromatin Dynamics
- Evaluation and Optimization Models
- Genetics, Bioinformatics, and Biomedical Research
- Single-cell and spatial transcriptomics
- Chronic Lymphocytic Leukemia Research
Microsoft (United States)
2015-2024
Personalis (United States)
2023
Microsoft Research (United Kingdom)
2023
Purdue University West Lafayette
2023
Johns Hopkins University
2023
Illumina (United States)
2022
Menlo School
2019-2022
Xingtai University
2010-2021
Chery Automobile (China)
2021
Grail (United States)
2019-2020
Early cancer detection could identify tumors at a time when outcomes are superior and treatment is less morbid. This prospective case-control sub-study (from NCT02889978 NCT03085888) assessed the performance of targeted methylation analysis circulating cell-free DNA (cfDNA) to detect localize multiple types across all stages high specificity.
G9a and GLP are conserved protein methyltransferases that play key roles during mammalian development through mono- dimethylation of histone H3 Lys 9 (H3K9me1/2), modifications associated with transcriptional repression. During embryogenesis, large H3K9me2 chromatin territories arise have been proposed to reinforce lineage choice by affecting high-order structure. Here we report in adult human hematopoietic stem progenitor cells (HSPCs), absent primitive formed de novo commitment. In...
Purpose:. We recently reported the development of a cell-free DNA (cfDNA) targeted methylation (TM)-based sequencing approach for multi-cancer early detection (MCED) test that includes cancer signal origin prediction. Here, we evaluated prognostic significance by MCED using longitudinal follow-up data.Experimental Design:. As part Circulating Cell-free Genome Atlas (CCGA) substudy, plasma cfDNA samples were sequenced TM approach, and machine learning classifiers predicted status origin....
Abstract Purpose: We developed a method to monitor copy number variations (CNV) in plasma cell-free DNA (cfDNA) from patients with metastatic squamous non–small cell lung cancer (NSCLC). aimed explore the association between tumor-derived cfDNA and clinical outcomes, sought CNVs that may suggest potential resistance mechanisms. Experimental Design: Sensitivity specificity of low-pass whole-genome sequencing (LP-WGS) were first determined using line cfDNA. LP-WGS was performed on baseline...
Development of specific immunotherapy for colorectal cancer (CRC) will require identification antigens selectively or exclusively expressed on CRC cells and strategies to induce enhance immune responses against these antigenic targets. Cancer-testis (C-T) are proving be excellent targets solid tumors such as melanoma, but their clinical utility treatment has date been limited by infrequent expression in cells. Here we report that the hypomethylating agent 5-aza-2′-deoxycytidine (DAC) induces...
Human dynamics are inextricably intertwined with the social, geographical and economic environment. The continuous flux of people communicating as well migrating, commuting, traveling inevitably spans acquaintances across geographic space that is far from random exhibits regular patterns. For instance, it has been shown probability being acquainted someone closely related to inverse distance between them. In this paper we investigate aggregated mobile phone call detail records a large US...
The formation of chromatin domains is an important step in lineage commitment. In human hematopoietic stem and progenitor cells (HSPCs), G9a/GLP-dependent H3K9me2 territories form de novo during specification are nucleated at punctate sites Here, we examined the patterning HSPCs consequences for structure. We profiled accessibility across genome treated with either a small molecule inhibitor G9a/GLP or DMSO. observed that dramatically altered regions nucleation. have characterized...
Protein kinase signaling regulates human hematopoietic stem/progenitor cell (HSPC) fate, yet little is known about critical pathway substrates. To address this, we have developed and applied a large‐scale, empirically optimized phosphopeptide affinity enrichment strategy with high‐throughput 2D LC‐MS/MS screening to evaluate the phosphoproteome of an isolated CD34 + HSPC population. We first used hydrophilic interaction chromatography as dimension separation separate simplify protein digest...
Software maintenance ensure the normal operation of basic work, accurate cost estimation necessary software tools. The Article describe types maintenance, analysis impact costs technical factors and non-technical factors, give model improvement models for use form lists affecting workload maintaining weight. Basic to estimate is multiplied by annual change in project development conflict; improve each It can appropriate adjustments affect weight at last, accuracy estimation. propose method...
Software maintenance is an important stage of software life cycle, according to the problems process model, research focus on after delivery retire between activities. Firstly, descript eight process, then, model structure and content, including rapid change Boehm IEEE iterative enhancement four models, finally, analyze models provide basis for selection model. This study's content includes improvement guide activities, improve quality maintenance, ensure normal application software, which...
Fuzzy rule is the core of fuzzy expert system, which use relational database methods knowledge to build base, combination and base development trend base. This paper describes rules first, including logic, production rules, multi-dimensional rules; studies representation, general representation representation; finally researches construction Knowledge Base System Structure table structure. The results show that type reflects relationship between deductive reasoning logical implication way a...
1545 Background: Screening tests for early cancer detection are often criticized due to risk of overdiagnosis—detection good prognosis cancers which may not require immediate treatment. We recently reported development cfDNA sequencing approaches detection; longitudinal follow-up (F/U) data were utilized here evaluate prognostic significance using cfDNA. Methods: Plasma samples subjected whole-genome bisulfite (WGBS, 30X) as part a previously-reported Circulating Cell-free Genome Atlas...
243 Background: Circulating Cell-free Genome Atlas (CCGA; NCT02889978) is a multi-center, case-control, observational study with longitudinal follow-up to develop cfDNA assay in which classifiers were trained on whole-genome bisulfite sequencing (WGBS) and targeted methylation (TM) data for detection of multiple cancer types. Previously, we showed that the fraction ctDNA fragments (TF) was stronger predictor than clinical stage an equivalent survival. Given CRC tumors can be described via...
For urban water consumption characteristics of the process will be applied to neural network model for forecasting demand. Describes feed-forward and feedback model; study weight function based on orthogonal basis started learning algorithm, describes specific steps algorithm; drawn flowchart forecast, according relevant historical data training analyze value prediction generate predicted actual fitting curve. The results showed that demand has a certain theoretical practical value.
Configuration management tool play an important role in software project management, it can solve a lot of problems which trouble the managers, selection involve many factors, is multifactor, complex systems engineering problem. In this paper, use method fuzzy decision analysis to study. First, evaluation indicators configuration tool, hierarchy diagram function, performance, cost, service and other indicators, where after, study multi-objective method, including constructing factors index...
Fuzzy rule representation is a core of the model expert system, through analysis traditional knowledge implementation disadvantages method, propose combine database and base integration, using relational to express fuzzy rules knowledge. First, designed convert method corresponding table structure, then describe rules, study cartesian product based on relationship between representation. Finally, concrete example Using this advantage that queries can be used in place reasoning, improve...
Network teaching integration platform is the education development needs. According to network platform's problems in current, this paper presents a design idea which based on MVC framework. Through of framework research structure, three major structure and system The use functional block diagram show features, include organization management, online communication, assessment, download center. results that modern information technology support, future trend, bound accelerate process for...
Abstract The Anopheles gambiae 1000 Genomes (Ag1000G) Consortium previously utilized deep sequencing methods to catalogue genetic diversity across African An. populations. We analyzed the complete datasets of 1142 individually sequenced mosquitoes through Microsoft Premonition’s Bayesian mixture model based (BMM) metagenomics pipeline. All specimens were confirmed as either sensu stricto (s.s.) or coluzzii with a high degree confidence ( > 98% identity reference). Homo sapiens DNA was...
Development of information technology, can provide efficient, safe, convenient support platform to logistics and distribution companies, improve economic benefits. The problem the lack geographic actual line with calculation line, routing optimizing, introduction Web GIS, research key technologies. First, given a graphical GIS which based on optimizing; secondly, study optimizing algorithm, including model representation reverse dynamic programming algorithm; again, spatial data structure,...
Reasonable choice of logistics center location, has important significance, for optimizing the regional industrial layout, and promoting development modern industry. For problems such as location by many influence factors, decision-making evaluation program are complex, this paper use rough sets method to study. first, analyze factors build index system, second, on basis properties importance formula which been given, study attributes knowledge acquisition algorithm, then decision model...