Previous research has demonstrated that traumatic brain injury (TBI) activates autophagy and a neuroinflammatory cascade contributes to substantial neuronal damage behavioral impairment, Toll-like receptor 4 (TLR4) is an important mediator of this cascade. In the present study, we investigated hypothesis resveratrol (RV), natural polyphenolic compound with potent multifaceted properties, alleviates mediated by TLR4 following TBI. Adult male Sprague Dawley rats, subjected controlled cortical...

Microbial transformation of ginsenosides to increase its pharmaceutical effect is gaining increasing attention in recent years. In this study, Cellulosimicrobium sp. TH-20, which was isolated from soil samples on ginseng grown, exhibited effective ginsenoside-transforming activity. After protopanaxadiol (PPD)-type ginsenoside (Rb1) and protopanaxatriol (PPT)-type (Re Rg1) were fed C. TH20, a total 12 metabolites, including 6 new intermediate identified. Stepwise deglycosylation...

Traumatic brain injury (TBI) is usually caused by accidental injuries and traffic accidents, with a very high mortality rate. Treatment management following TBI are essential to reduce patient help improve long‑term prognosis. Wogonin flavonoid compound an antioxidant effect extracted from Scutellaria baicalensis Georgi. However, the function mechanism of wogonin in protecting remain be elucidated. The present study established model Sprague‑Dawley rats treated them trauma. results showed...

Traumatic brain injury (TBI) is a worldwide phenomenon which results in significant neurological and cognitive deficits humans. Vitamin D (VD) implicated as therapeutic strategy for various diseases now. Recently, inhibition of the NADPH oxidase (NOX 2 ) was reported to protect against oxidative stress (ROS) production. However, whether alterations NOX expression activity are associated with calcitriol (active metabolite VD) treatment following TBI remains unclear. In present study, rats...

Traumatic brain injury (TBI) involves primary and secondary cascades that underlie delayed neuronal dysfunction death, leading to long‑term cognitive deficits, effective therapeutic strategies targeting death remain elusive. The present study aimed determine whether the administration of resveratrol (100 mg/kg) was able significantly enhance functional recovery in a rat model TBI treatment upregulate synaptic protein expression suppress post‑TBI autophagy. results demonstrated daily with...

Abstract Background Gestational diabetes mellitus (GDM) is the most common medical complication associated with pregnancy, which may impose risks on both mother and fetus. Micro RNAs (miRNAs) long noncoding (lncRNAs) are implied as vital regulators in GDM. A recent paper revealed dysregulation of miR-33a-5p placental tissues GDM patients. However, biological function remains elusive. This study focused exploring underlying mechanisms Methods 12 pregnancies healthy were enrolled study. INS-1...

Previous studies have demonstrated that global cerebral ischemia (GCI) causes neurological deficits and neuronal cell apoptosis. Calcitriol, a biologically active metabolite of vitamin D, exerts its endocrinological influence via nuclear D receptor. It is being assessed as an emerging therapeutic strategy in models various medical conditions, including acute brain injury. The purpose the present study was to investigate neuroprotective effects calcitriol on GCI further refine potential...

Inhibition of Toll-like receptor 4 (TLR4)-mediated inflammatory pathways exerts a critical effect on neuronal death; therefore, it is possible new therapeutic approach for traumatic brain injury (TBI). Resatorvid (TAK-242) novel small-molecule compound widely used to inhibit TLR4-mediated pathways, but the protective mechanism TAK-242 in TBI remains unclear. Herein, we analyzed neuroprotective effects rats after TBI. The rat model was established using modified Free-fall device, and were...

Abstract Chronic microbial infection influences cancer progression, but the mechanisms that link them remain unclear. Constitutive androstane receptor (CAR) is a nuclear regulates enzymes involved in endobiotic and xenobiotic metabolism. CAR activation mechanism of tumor promotion; however, effects chronic on promotion have not been studied context function. Here, we report limits infection–associated progression liver cancer. knockout (KO) wild-type (WT) male mice were treated with or...

It has previously been demonstrated that bone marrow stromal cells (BMSCs) exhibit great therapeutic potential in neuronal injuries; however, there is limited understanding of the precise underlying mechanisms contribute to functional improvement following brain injury. The aim present study was assess effect BMSC treatment on traumatic injury (TBI) rats, and investigate if they migrate injured areas promote neuromotor recovery via upregulation neurotrophic factors synaptic proteins. BMSCs...

Corticotropin-releasing factor (CRF) and its receptors have been detected in numerous tumors an important role tumorigenesis proliferation. However, the of these peptides has not established human glioma malignant cell lines. The present study evaluated for first time, expression CRF receptor 1 (CRFR1) 35 samples, 13 normal brain tissues U87 cells using immunohistochemistry, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) western blot analysis. Levels CRFR1 were...

Preeclampsia (PE) is a common medical complication of pregnancy characterized by high blood pressure and proteinuria after the 20th gestational week. This study aimed to investigate potency combination curcumin aspirin in treatment PE explore underlying mechanisms.The model was constructed female rats administering 0.5 mg/mL N-nitro-L-arginine methyl ester from days (GDs) 6 16. The pregnant were divided into five groups according drug treatment. or given tail vein injection (0.36 mg/kg)...

The prevalence of gastric Helicobacter pylori (Hp) infection is ~50% the world population. However, how Hp influences inflammatory bowel disease in humans not fully defined. In this study, we examined whether co-infection with influenced hepaticus (Hh)-induced intestinal pathology Rag2-/- mice. mice both sexes were infected Hh, which a subgroup was followed by two weeks later. Co-infected males, but females, had significantly higher total colitis index scores colon at 10 and 21 post-Hh (WPI)...

Pre-eclampsia (PE) is a pregnancy-associated disease characterized by placental dysfunction and increased oxidative stress. Apocyanin potent antioxidant anti-inflammatory which has shown beneficial effects on PE pathogenesis. Aspirin recognized as the recommendable drug in prevention therapy. Therefore, we aimed to investigate of combining apocyanin aspirin treat rat models induced N-nitro-L-arginine methyl ester (L-NAME) from gestational day (GD) 6 16 elucidate potential mechanisms.First,...

Objective To observe the changes of serum advanced glycosylation end products(AGEs) in newly diagnosed type 2 diabetes, and to explore relationship with insulin resistance β-cell first-phase secretion function. Methods A total 56 patients diabetes(diabetes group) were included from Affiliated Hospital Qingdao University Medical College January 2010 June 2011, according WHO diagnostic criteria diabetes mellitus (1999). The mean age was (40±7) years, including 45 male 11 female....

[Summary] To explore the mRNA expression of insulin-like growth factor-Ⅰ (IGF-Ⅰ),extracellular signal regulated kinase (ERK),and glucose transporter 4 (GLUT4) in greater omental adipose tissue patients with metabolic syndrome and colorectal cancer.The IGF-Ⅰ,ERK,and GLUT4 subjects was measured by RT-PCR.(1) The level IGF-Ⅰ ERK group significantly higher than that control (P＜0.01),while cancer subgroup non-colorectal (P＜ 0.01).The obviously lowered (P＜0.01).(2) positively correlated (r...

Hepatocellular carcinoma (HCC) is a male-predominant cancer. Like human viral hepatitis, Helicobacter hepaticus infection of A/JCr mice produces chronic hepatitis and HCC with male bias. We used this model to test the hypothesis that androgen ablation mature would protect against HCC, conversely receptor agonism promote tumors. At 1 year age, without H. were distributed into 4 groups: surgical castration, chemical castration dihydrotestosterone (DHT) oversupplementation, or intact controls....