A5103011613- Structural Analysis and Optimization
- Radiomics and Machine Learning in Medical Imaging
- Dynamics and Control of Mechanical Systems
- Gastric Cancer Management and Outcomes
- Advanced Materials and Mechanics
- Immune cells in cancer
- Robotic Mechanisms and Dynamics
- Structural Engineering and Vibration Analysis
- Vibration and Dynamic Analysis
- Acoustic Wave Phenomena Research
- Antenna Design and Optimization
- Advanced Antenna and Metasurface Technologies
- Structural Health Monitoring Techniques
- Robotic Path Planning Algorithms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Space Satellite Systems and Control
- Cytokine Signaling Pathways and Interactions
- Modular Robots and Swarm Intelligence
- Electrical Contact Performance and Analysis
- Architecture and Computational Design
- Geology and Paleoclimatology Research
- Probabilistic and Robust Engineering Design
- Mechanical stress and fatigue analysis
- Adhesion, Friction, and Surface Interactions
- Mechanical Engineering and Vibrations Research
Xidian University
2016-2025
Southern Medical University
2015-2023
Nanfang Hospital
2015-2023
South China Sea Institute Of Oceanology
2012-2022
Guangzhou Education Bureau
2022
Ministry of Natural Resources
2022
Ministry of Natural Resources
2020
Third Affiliated Hospital of Sun Yat-sen University
2011-2018
Sun Yat-sen University
2011-2018
Jilin University
2015-2016
We postulated that the ImmunoScore (IS) could markedly improve prediction of postsurgical survival and chemotherapeutic benefits in gastric cancer (GC).A model for GC patients was developed using data from 879 consecutive patients.The expression 27 immune features detected 251 specimens by immunohistochemistry, a 5-feature-based ISGC then constructed LASSO Cox regression model. Testing validation cohorts were included to validate model.Using model, we established an classifier based on 5...
Deployable space structure technology is an approach used in building spacecraft, especially when realizing deployment and folding functions. Once orbit, the structures are released from fairing, deployed, positioned. With development of communication, remote-sensing, navigation satellites, space-deployable have become cutting-edge research topics science technology. This paper summarizes current status trend China, including large mesh antennas, solar arrays, deployable mechanisms for...
The functional association between intronic miRNAs and their host genes is still largely unknown. We found that three gene loci, which produced miR-26a miR-26b, were embedded within introns of coding for the proteins carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase (CTDSP) family, including CTDSPL, CTDSP2 CTDSP1. conducted serum starvation-stimulation assays in primary fibroblasts two-thirds partial-hepatectomies mice, revealed miR-26a/b CTDSP1/2/L expressed...
Abstract Molecular biomarkers that predict disease progression might promote drug development and therapeutic strategies in aggressive cancers, such as gastric cancer (GC). High-throughput mRNA sequencing (RNA-seq) revealed collagen type X alpha 1 (COL10A1) is a progression-associated gene. Analysis of 103 GC patients showed high COL10A1 expression was associated with metastasis reduced survival. We analyzed the promoter using UCSC genome website JASPAR database, we found potential SOX9...
Cancer-associated fibroblasts (CAFs) are reported to support tumorigenesis by stimulating angiogenesis, cancer cell proliferation, and invasion in most solid tumors. However, the roles of CAFs liver microenvironment have not been thoroughly studied. In our previous study, we successfully isolated from hepatocellular carcinoma (HCC) (H-CAFs) proved that H-CAFs suppressed activation NK cells thereby created favorable conditions for HCC progression. present found proliferation MHCC97L Hep3B was...
Purpose: Elevated levels of neutrophils have been associated with poor survival in various cancers, but direct evidence supporting a role for the immunopathogenesis human cancers is lacking.Experimental Design: A total 573 patients gastric cancer were enrolled this study. Immunohistochemistry and real-time PCR performed to analyze distribution clinical relevance different microanatomic regions. The regulation function assessed both vitro vivoResults: Increased neutrophil counts peripheral...
Purpose: Current tumor-node-metastasis (TNM) staging system cannot provide adequate information for prediction of prognosis and chemotherapeutic benefits. We constructed a classifier to predict identify subset patients who can benefit from adjuvant chemotherapy.Experimental Design: detected expression 15 immunohistochemistry (IHC) features in tumors 251 gastric cancer (GC) evaluated the association their level with overall survival (OS) disease-free (DFS). Then, integrating multiple...
The tumor microenvironment (TME) plays a critical role in disease progression and is key determinant of therapeutic response cancer patients. Here, we propose noninvasive approach to predict the TME status from radiological images by combining radiomics deep learning analyses. Using multi-institution cohorts 2,686 patients with gastric cancer, show that model accurately predicted an independent prognostic factor beyond clinicopathologic variables. further predicts benefit adjuvant...
Substantial progress has been made in using deep learning for cancer detection and diagnosis medical images. Yet, there is limited success on prediction of treatment response outcomes, which important implications personalized strategies. A significant hurdle clinical translation current data-driven models lack interpretability, often attributable to a disconnect from the underlying pathobiology. Here, we present biology-guided approach that enables simultaneous tumor immune stromal...
Defects in natural killer (NK) cell functions are necessary for tumor immune escape, but their underlying regulatory mechanisms human cancers remain largely unknown. Here we showed, detailed studies of NK cells from 235 untreated patients with gastric cancer (GC), the density GC tissues could predict improved survival patients. However, were significantly decreased number advanced-stage GC. A multivariate Cox analysis revealed that intratumoral was an independent prognostic factor overall...
Deployable high-frequency mesh reflector antennas for future communications and observations are required to obtain high gain directivity. In order support these new missions, reflectors with surface accuracy widely required. The form-finding analysis of deployable becomes more vital which aims determine the initial profile formed by equilibrium prestress distribution in cables satisfy requirement. this paper, two methods antennas, both include steps, proposed. first step is investigate...
Drug resistance is the major challenge facing cancer chemotherapy and nanoscale delivery systems based on natural materials, such as sericin, are a promising means of overcoming drug resistance. Yet, no attempt introducing synthetic poly(γ-benzyl-L-glutamate) (PBLG) onto sericin polypeptide to fabricate facile biocompatible biodegradable micelle has been tried. Here, we prepared polypeptide-based amphiphilic polymer containing hydrophilic backbone PBLG side chains via ring-opening...