A5016774657- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Stress Responses and Cortisol
- Parasitic Infections and Diagnostics
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Tryptophan and brain disorders
- Helicobacter pylori-related gastroenterology studies
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- IL-33, ST2, and ILC Pathways
- Bladder and Urothelial Cancer Treatments
- Psoriasis: Treatment and Pathogenesis
- Gastroesophageal reflux and treatments
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
- Neonatal and fetal brain pathology
Gansu Provincial Hospital
2017-2022
Lanzhou City University
2017
Sichuan University
2012-2015
Metabolic reprogramming is characterized by dysregulated levels of metabolites and metabolic enzymes. Integrated metabolomic transcriptomic data analysis can help to elucidate changes in the enzymes, screen core pathways, develop novel therapeutic strategies for cancer.Here, metabolome gastric cancer tissues was determined using liquid chromatography-mass spectrometry. The transcriptome from Cancer Genome Atlas dataset were integrated with spectrometry identify common cancer-specific...
Although the Ficoll-Paque method is classically used to isolate peripheral blood mononuclear cells (PBMCs), modifications in this are required for a more rapid and economic output biobanks clinical laboratories, particularly developing countries. In study, we addressed issue by modifying isolation of PBMCs or from umbilical cord healthy diseased (infected, anemic, chronic obstructive pulmonary disease) adult individuals. modified method, initiated cell process buffy coat layer, which appears...
Hypothalamic dysfunction is a key pathological factor in inflammation-associated depression. In the present study, isobaric tags for relative-absolute quantitation (iTRAQ) combined with mass spectrometry and gas chromatography-mass (GC-MS) were employed to detect proteomes metabolomes hypothalamus of lipopolysaccharide (LPS)-induced depression mouse, respectively. A total 187 proteins 27 metabolites differentially expressed compared control group. Following integration bi-omics data,...
Imbalances of amino acids and the purinergic system show significant hypothalamic metabolic perturbations, which are closely associated with mechanisms depression.
BCG, the only registered vaccine against Mycobacterial Tuberculosis (TB) infection, has been questioned for its protective efficacy decades. Although lots of efforts were made to improve BCG antigenicity, few studies devoted understand role host factors in variability protection. Using IL-10KO mice and pulmonary tuberculosis infection model, we have addressed IL-10 vaccination efficacy. The data showed that IL-10-deficient dendritic cells (DCs) could promote immune responses through...
Hepatitis B virus (HBV) infection remains a severe clinical concern in China. Of note, the progression of HBV varies between different populations. To identify factors that influence disease and prognosis, total 478 chronic HBV-infected patients were enrolled, liver function parameters, DNA levels hepatic fibrosis indices analyzed. First, results demonstrated significant difference hepatitis e antigen (HBeAg) expression male female (χ2=4.061, P=0.044). Furthermore, when comparing either...
Background . Early diagnosis of hypoxic‐ischaemic encephalopathy (HIE) is crucial in preventing neurodevelopmental disabilities and reducing morbidity mortality. The study was to investigate the plasma metabolic signatures peripheral blood HIE newborns explore potential diagnostic biomarkers. Method In present study, 24 with healthy controls were recruited. metabolites measured by gas chromatography‐mass spectrometry (GC‐MS), raw data standardized EigenMS method. Significantly differential...
Latent Mycobacterium tuberculosis (Mtb) infection (LTBI) is the main clinical manifestation after Mtb exposure. During latent phase, retards attempts of eradication by host immune system. The dormancy survival regulator (DosR) held as essential for persistence. Rv1737c predominantly expressed in infection. However, role evasion still largely unknown. In this study, we have characterized functions recruitment and activation macrophages, which play a cardinal innate adaptive immunity. For...
Abstract Background Hepatitis B virus (HBV) infection is a crucial medical issue worldwide. The dependence of HBV replication on host cell machineries and their co-evolutionary interactions prompt the codon usage pattern viral genes to translation selection mutation pressure. Objective evolutionary characteristics natural effects human genome were analyzed provide basis for medication development infection. Methods sequences from different genotypes our isolates reference downloaded National...
Abstract Cholangiocarcinoma (CCA) is a highly malignant disease with poor prognosis, and mechanisms of initiation development are not well characterized. It long noncoding RNAs (lncRNAs) acting as miRNA decoys to regulate cancer-related in competing endogenous RNA (ceRNA) networks that suggest possible molecular mechanism CCA. The current study aims find potential prognosis biomarkers small molecule therapeutic targets based on the construction CCA prognosis-related ceRNA network. A...
There is an urgent need to identify the potential risk factors for activating latent Mycobacterium tuberculosis infection. In this study, we evaluated immune function of Rv1737c, which a latency-associated antigen dormancy survival regulator (DosR) M. in mouse model. Our data showed that mice pretreated with recombinant Rv1737c (rRv1737c) exhibited higher levels antigen-specific antibodies (IgG, IgM and IgA) than sham-treated mice. Following Bacilli Calmette-Guerin (BCG) challenge, rRv1737c...
Serum pepsinogens (PGs) are biomarkers for gastric mucosal damage and have been reported to be associated with atherosclerosis. Its correlation atherosclerotic cardiovascular disease (ASCVD) is still unknown. This study aimed explore the association between serum PGs ASCVD providing physicians an integrative picture make rational plans in diagnosis treatment of ASCVD.The concentrations their distributions non-ASCVD were compared by non-parametric test, Chi-squared test Fisher exact test. The...
Background: Serum pepsinogen (PG), as a valuable biomarker for gastric mucosal injury, has been proposed risk factor development of metabolism diseases. The research is to systematically evaluate the features PG in cardiovascular disease (CVD) Northwest China.
Abstract Background: Cholangiocarcinoma (CCA) is a highly malignant disease with poor prognosis. Its occurrence and development mechanisms remain unearthed. The ceRNA network describes the relationship between cancer-related RNAs reveals potential regulatory mechanism in CCA pathogenesis. Method: genome transcriptome dataset of was downloaded from TCGA database. Differential expressional survival analysis were performed by "edgeR" "survival" package R soft (|logFC|≥2, adjusted...
At present, the pepsinogen reference values applicable to subjects from Gansu province have not been established. Therefore, current study aimed establish for PGI, PGII, and PGI/ PGII ratio in Province, Northwest China.The present was a cross-sectional study. Following screening physical examination center of Provincial Hospital, 2,130 healthy were enrolled (age range 18 - 88 years; BMI 15.35 38.89 kg/m2) March 2018 December 2020. Serum PGI PG II concentration levels detected by...