A5010759658- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Mental Health via Writing
- Heart Rate Variability and Autonomic Control
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Pain Management and Placebo Effect
- Emotion and Mood Recognition
- Pain Mechanisms and Treatments
- Psychosomatic Disorders and Their Treatments
- Botulinum Toxin and Related Neurological Disorders
- Treatment of Major Depression
- Neurosurgical Procedures and Complications
- Schizophrenia research and treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurological disorders and treatments
- Brain Tumor Detection and Classification
- Traumatic Brain Injury and Neurovascular Disturbances
- Sympathectomy and Hyperhidrosis Treatments
- Mental Health and Psychiatry
- Traumatic Brain Injury Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vagus Nerve Stimulation Research
Stanford University
2016-2024
Acacia Pharma (United Kingdom)
2024
Acacia Research Corporation (United States)
2023
Pain and Headache Center
2020-2022
University Health Network
2011-2017
University of Toronto
2008-2015
Toronto Rehabilitation Institute
2008
1 Abstract To extract patterns from neuroimaging data, various statistical methods and machine learning algorithms have been explored for the diagnosis of Alzheimer’s disease among older adults in both clinical research applications; however, distinguishing between healthy brain data has challenging (age > 75) due to highly similar atrophy image intensities. Recently, cutting-edge deep technologies rapidly expanded into numerous fields, including medical analysis. This paper outlines...
Summary Trigeminal neuralgia patients have microstructural abnormalities in their trigeminal nerves and brain white matter connecting regions involved pain perception, attention, motor functions. Idiopathic (TN) is classically associated with neurovascular compression (NVC) of the nerve at root entry zone (REZ), but NVC-induced structural alterations are not always apparent on conventional imaging. Previous studies report lower fractional anisotropy (FA) affected TN using diffusion tensor...
Objective Idiopathic trigeminal neuralgia (TN) is characterized by paroxysms of severe facial pain but without the major sensory loss that commonly accompanies neuropathic pain. Since neurovascular compression nerve root entry zone does not fully explain pathogenesis TN, we determined whether there were brain gray matter abnormalities in a cohort idiopathic TN patients. We used structural MRI to test hypothesis associated with altered (GM) areas involved and affective aspects pain,...
In Brief Classical trigeminal neuralgia (TN) is a severe neuropathic facial pain disorder commonly associated with neurovascular compression at the nerve root entry zone (REZ). Neurosurgical interventions can relieve TN pain, but mechanisms underlying these effects are unknown. We determined whether abnormalities we previously reported REZ of patients using diffusion tensor imaging (DTI) and brain gray matter (GM) analyses resolve after effective neurosurgical treatment. Twenty-five who...
Advances in applied machine learning techniques for neuroimaging have encouraged scientists to implement models diagnose brain disorders such as Alzheimer's disease at early stages. Predicting the exact stage of is challenging; however, complex deep can precisely manage this. While successful, these architectures are difficult interrogate and computationally expensive. Therefore, using novel, simpler with more efficient pattern extraction capabilities, transformers, interest neuroscientists....
Abstract Hypnotizability, one’s ability to experience cognitive, emotional, behavioral and physical changes in response suggestions the context of hypnosis, is a stable neurobehavioral trait associated with improved treatment outcomes from hypnosis-based therapy. Increasing hypnotizability people who are low-to-medium hypnotizable individuals could improve both efficacy effectiveness therapeutic hypnosis as clinical intervention. Hypnotizability dorsolateral prefrontal cortex (DLPFC)...
Temporal summation of pain (TSP), the perception increasingly greater evoked by repetitive noxious stimuli, is highly variable between individuals. Individuals with facilitated processing and/or reduced pain-modulatory capabilities are regarded as pronociceptive, whereas individuals capacity characterized antinociceptive. Brodmann area (BA) 3a primary somatosensory cortex part an ascending pathway from sensory thalamus that mediates TSP. Descending modulation involves projections subgenual...
Background: Trigeminal neuralgia secondary to multiple sclerosis (MS-TN) is a facial neuropathic pain syndrome similar classic trigeminal (TN). While TN caused by neurovascular compression of the fifth cranial nerve (CN V), how MS-related demyelination correlates with in MS-TN not understood. Objectives: We aim examine diffusivities along CN V MS-TN, TN, and controls order reveal differential neuroimaging across groups. Methods: 3T MR diffusion weighted, T1, T2 FLAIR sequences were acquired...
Mild cognitive impairment (MCI) represents the intermediate stage between normal cerebral aging and dementia associated with Alzheimer's disease (AD). Early diagnosis of MCI AD through artificial intelligence has captured considerable scholarly interest; researchers hope to develop therapies capable slowing or halting these processes. We developed a state-of-the-art deep learning algorithm based on an optimized convolutional neural network (CNN) topology called MCADNNet that simultaneously...
Diffusion-weighted imaging (DWI)-based tractography has gained increasing popularity as a method for detailed visualization of white matter (WM) tracts. Different techniques, and more novel, advanced methods provide significant WM structural detail. While there been greater focus on improving tract larger pathways, the relative value each cranial nerve reconstruction how this methodology can assist surgical decision-making is still understudied. Images from ten patients with posterior fossa...
The measurement and monitoring of generalized anxiety disorder requires frequent interaction with psychiatrists or psychologists. Access to mental health professionals is often difficult because high costs insufficient availability. ability assess passively at intervals could be a useful complement conventional treatment help relapse monitoring. Prior work suggests that higher levels are associated features human speech. As such, speech using personal smartphones other wearable devices may...
Migraine is a heterogeneous disorder with variable symptoms and responsiveness to therapy. Because of previous analytic shortcomings, variance in migraine has been inconsistently related brain function. In the current analysis, we used data from two sites (<i>n</i> = 143, male female humans), performed canonical correlation relating resting-state functional connectivity (RSFC) broad range symptoms, ranging headache characteristics sleep abnormalities. This identified three dimensions...
Objectives The objectives of this cross‐sectional pilot study were threefold: to identify regions cortical thickness that differentiate chronic migraine (CM) from controls, assess group differences in interregional covariance, and determine associations between clinical variables thickness. Background Cortical alterations relation features have not been adequately explored CM. Assessment relationship can be useful describe substrates for disease progression warrant management emphasis....