A5003292485- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Treatment of Major Depression
- Transcranial Magnetic Stimulation Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurological disorders and treatments
- Stress Responses and Cortisol
- EEG and Brain-Computer Interfaces
- Child and Adolescent Psychosocial and Emotional Development
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Psychosomatic Disorders and Their Treatments
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Muscle activation and electromyography studies
- Anomaly Detection Techniques and Applications
- Axon Guidance and Neuronal Signaling
- Electroconvulsive Therapy Studies
- Voice and Speech Disorders
- Cannabis and Cannabinoid Research
- Schizophrenia research and treatment
- Cognitive Computing and Networks
- Nerve injury and regeneration
Harvard University
2024-2025
University of Minnesota
2019-2024
Twin Cities Orthopedics
2023-2024
Circuit Therapeutics (United States)
2024
Brigham and Women's Hospital
2024
University of Minnesota System
2019-2024
California University of Pennsylvania
2023
Yale New Haven Hospital
2018
Yale University
2018
New York Psychoanalytic Society and Institute
2016-2017
<b><i>Introduction:</i></b> Ketamine has emerged as a rapid-acting antidepressant. While ongoing treatment can prevent relapse, concerns exist regarding long-term exposure. <b><i>Objective:</i></b> We conducted randomized trial to examine the feasibility and efficacy of cognitive behavioral therapy (CBT) following intravenous ketamine in treatment-resistant depression (TRD). <b><i>Methods:</i></b> Subjects with TRD were...
Ketamine has emerged as a rapid-acting antidepressant, though controversy remains whether sufficient data exist to justify its use outside of research protocols. In October 2014, the authors' institution began providing ketamine an off-label therapy on case-by-case basis for patients unable participate in Here, participant experience during 29 months clinical treatment severe and treatment-resistant mood disorders through February 2017 is described.Patients were initially treated with...
Causal network mapping is an emerging technique that can be used to derive optimal disorder/symptom-specific brain stimulation targets. This exploits incidental variability in lesion and locations, which creates a natural experiment causal inferences drawn between lesions or modulation of specific circuits clinical outcomes. Circuits identified by mapping, referred as symptom-networks, represent candidate The number psychiatric symptom-networks has grown rapidly recent years, creating need...
<title>Abstract</title> Causal network mapping is an emerging technique that can be used to derive optimal disorder/symptom-specific brain stimulation targets. This exploits incidental variability in lesion and locations, which creates a natural experiment causal inferences drawn between lesions or modulation of specific circuits clinical outcomes. Circuits identified by mapping, referred as symptom-networks, represent candidate The library psychiatric symptom-networks has grown rapidly...
BackgroundPrefrontal abnormalities in schizophrenia have consistently emerged from resting state and cognitive neuroimaging studies. However, these correlative findings require causal verification via combined imaging/stimulation approaches. To date, no interleaved transcranial magnetic stimulation functional resonance imaging study (TMS fMRI) has probed putative prefrontal cortex schizophrenia.Objective/Hypothesis: We hypothesized that subjects with would show significant hyperexcitability...
Abstract Transcranial magnetic stimulation (TMS) and deep brain (DBS) can treat some neuropsychiatric disorders, but there is no consensus approach for identifying new targets. We localized causal circuit-based targets anxiety that converged across multiple natural experiments. Lesions (n=451) TMS sites (n=111) modify mapped to a common normative circuit (r=0.68, p=0.01). In an independent dataset (n=300), individualized site connectivity this predicted change (p=0.02). Subthalamic DBS...
Fear overgeneralization is a promising pathogenic mechanism of clinical anxiety. A dominant model posits that hippocampal pattern separation failures drive overgeneralization. Hippocampal network targeted transcranial magnetic stimulation (HNT-TMS) has been shown to strengthen hippocampal-dependent learning/memory processes. However, no study examined whether HNT-TMS can alter fear learning/memory. Continuous theta-burst (cTBS) was delivered individualized left posterior parietal sites...
Background and Objectives Fear conditioning represents the prevailing model by which organisms acquire novel threat contingencies. However, little work has been devoted to linking laboratory measures of fear development real-world responses. To fill this gap, present study explored whether individual differences in a laboratory-based measure could predict levels COVID-19-related anxiety avoidance assessed during first month pandemic.Design Method Forty-eight undergraduate students who had...
Exposure therapy is a first-line, empirically validated treatment for anxiety, obsessive-compulsive, and trauma-related disorders. Extinction learning the predominant theoretical framework exposure therapy, whereby repeated disconfirmation of feared outcome yields fear reduction over time. Although this has strong empirical support substantial translational utility, extinction unlikely to be sole process underlying therapeutic effects therapy. In our clinic, we commonly treat...
Theoretical and methodological research on threat conditioning provides important neuroscience-informed approaches to studying fear anxiety. The framework is at the vanguard of physiological neurobiological into core mechanistic symptoms anxiety-related psychopathology, providing detailed models neural circuitry underlying variability in clinically-relevant behaviors (e.g., decreased extinction, heightened generalization) heterogeneity clinical anxiety presentations. Despite strengths...