A5086154651- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Psychosomatic Disorders and Their Treatments
- Child and Adolescent Psychosocial and Emotional Development
- Treatment of Major Depression
- Sleep and Wakefulness Research
- Bipolar Disorder and Treatment
- Gambling Behavior and Treatments
- Child Abuse and Trauma
- Suicide and Self-Harm Studies
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Homelessness and Social Issues
- Neurological disorders and treatments
- Optical Imaging and Spectroscopy Techniques
- Sleep and related disorders
- Advanced Neuroimaging Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Electrolyte and hormonal disorders
- Traumatic Brain Injury Research
- Stress Responses and Cortisol
- Infant Health and Development
- Mental Health Treatment and Access
- Pain Management and Treatment
University of Minnesota
2021-2024
University of Minnesota System
2024
Mayo Clinic
2018-2024
Columbia University
2024
Twin Cities Orthopedics
2024
University of Minnesota Medical Center
2020-2021
WinnMed
2018-2021
Mayo Clinic in Florida
2020
Mayo Clinic in Arizona
2018
Objectives: The Patient Health Questionnaire-9 Modified (PHQ-9M) is a self-report tool used to assess the presence and severity of depressive symptoms in teenagers. Despite widespread use primary care clinics psychiatric settings, PHQ-9M has not been validated nor are its psychometric properties adequately understood for adolescent population. This study sought examine psychometrics treatment-seeking, depressed adolescents at psychopharmacology clinic who were concurrently assessed with...
Abstract The anterior cingulate cortex (ACC) is involved in emotion regulation and salience processing. Prior research has implicated ACC dysfunction suicidal ideation (SI) behavior. This study aimed to quantify glutamatergic concentrations examine relationships with SI a sample of healthy depressed adolescents. Forty adolescents underwent clinical evaluation proton magnetic resonance spectroscopy ( 1 H-MRS) at 3 T, utilizing 2-dimensional J -averaged PRESS sequence sampling medial pregenual...
Implicit cognitive markers may assist with the prediction of suicidality beyond clinical risk factors. The aim this study was to investigate neural correlates associated Death/Suicide Association Test (DS-IAT) via event-related potentials (ERP) in suicidal adolescents.Thirty inpatient adolescents ideations and behaviors (SIBS) 30 healthy controls from community were recruited. All participants underwent 64-channel electroencephalography, DS-IAT, assessments. Hierarchical generalized linear...
The goal of this study was to examine baseline transcranial magnetic stimulation measures cortical inhibition and excitability in depressed patients characterize their longitudinal posttreatment changes.
Major depressive disorder (MDD) is a common condition with heterogeneous presentations that often include predominant anhedonia. Previous studies have revealed childhood trauma potent risk factor for the development of MDD; however, clinical implications this finding are not fully understood.Participants were adolescents (age 13-21 years) diagnosis moderate-to-severe major and healthy controls. We used generalized linear models to assess relationship between anhedonia severity in...
Objectives: Prior studies demonstrate elevated cortical glutamate (Glu) in patients with bipolar disorder (BD). Studies assessing neurochemistry early stages of illness before the emergence manic symptoms are lacking. This study aimed to examine neurochemical correlates measured by proton magnetic resonance spectroscopy (1H-MRS) and a dimensional measure bipolarity sample depressed adolescents. Methods: Adolescent participants (aged 13–21 years) underwent semistructured diagnostic interview...
Repetitive transcranial magnetic stimulation (rTMS) therapy could be improved by better and earlier prediction of response. Latent class mixture (LCMM) non-linear mixed effects (NLME) modelling have been applied to model the trajectories antidepressant response (or non-response) TMS, but it is not known whether such models can predict clinical outcomes. We compared LCMM NLME approaches TMS in a naturalistic sample 238 patients receiving rTMS for treatment resistant depression (TRD), across...
Childhood adversity is a global health problem affecting 25–50% of children worldwide. Few prior studies have examined the underlying neurochemistry in adolescents. This cross-sectional study spectroscopic markers trauma cohort adolescents with major depressive disorder (MDD) and healthy controls. We hypothesized that historical would negative relationship measures glutamate metabolites anterior cingulate cortex. Adolescent participants (aged 13–21) underwent semi-structured diagnostic...
Objective: In this study, we aimed to evaluate age-dependent cognitive and behavioral changes, neuronal damage, the amount of gamma-aminobutyric acid-A (GABA-A) alpha 1 in immature, mature, adolescant rats after status epilepticus (SE).Materials Methods: SE was induced immature (17 days), (45 mature (150 days) using pentylenetetrazole (PTZ).After SE, underwent open field test Morris water maze test.After tests, animals were sacrificed performed histologic investigations on adolescant, assess...