A5101426093- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Neurological Disease Mechanisms and Treatments
- Cytokine Signaling Pathways and Interactions
- Bone health and osteoporosis research
- Traditional Chinese Medicine Analysis
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis B Virus Studies
- Intensive Care Unit Cognitive Disorders
- Diet and metabolism studies
- Anesthesia and Neurotoxicity Research
- Atherosclerosis and Cardiovascular Diseases
- Osteoarthritis Treatment and Mechanisms
- Herbal Medicine Research Studies
- Birth, Development, and Health
- Bone health and treatments
- Heavy Metal Exposure and Toxicity
- Natural product bioactivities and synthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Drug Transport and Resistance Mechanisms
- Traditional Chinese Medicine Studies
- Bone Metabolism and Diseases
- Heavy Metals in Plants
Anhui Medical University
2025
Second Hospital of Anhui Medical University
2025
University of South China
2016-2024
Nanjing Medical University
2024
First Affiliated Hospital of University of South China
2016-2021
Qilu Hospital of Shandong University
2013-2020
University of Alabama at Birmingham
2006-2018
University of Saskatchewan
2015
University of Hong Kong
2010-2012
HKUST Shenzhen Research Institute
2011-2012
The combined effects of physical activity (PA) and nitrogen dioxide (NO2) on fasting plasma glucose (FPG) levels have rarely been studied. This study aimed to examine whether long-term exposure NO2 attenuates the association between PA FPG in non-diabetic older adults. A total 2600 elderly Chinese adults were included this cross-sectional study. data collected using International Physical Activity Questionnaire (IPAQ). Space-Time Extra-Trees model was utilized estimate annual concentration...
IL-12 has been reported to affect thymic T cell selection, but the role of in involution not studied. We found that vivo, IL-12b knockout (IL-12b(-/-)) mice exhibited accelerated compared with wild-type (WT) B6 mice. This is characterized by an increase thymocytes early development stage phenotype CD25(-)CD44(+)CD4(-)CD8(-) aged IL-12b(-/-) Histologically, there were degeneration extracellular matrix and blood vessels, a significantly decreased cortex/medulla ratio, increased apoptotic cells...
Ibandronate (IBN) and pulsed electromagnetic field (PEMF) have each shown positive effects for treating osteoporosis, but no study has evaluated the relative of these treatments combined. This investigated IBN + PEMF on bone turnover, mineral density, microarchitecture, biomechanical properties in an ovariectomized (OVX) rat model osteoporosis. Fifty 3-month-old rats were randomly apportioned to receive a sham-operation (n = 10), or ovariectomy 40). The latter group was equally divided as...
Abstract In systemic lupus erythematosus (SLE), type I IFNs promote induction of IFN–stimulated genes (ISG) and can drive B cells to produce autoantibodies. Little is known about the expression distinct in lupus, particularly high-affinity IFN-β. Single-cell analyses transitional isolated from SLE patients revealed cell subpopulations, including IFN producers, responders, mixed producer/responder clusters. Anti-Ig plus TLR3 stimulation induced release bioactive that could stimulate HEK-Blue...
This study aimed to assess PEMF in a rat model of senile osteoporosis and its relationship with NLRP3-mediated low-grade inflammation the bone marrow microenvironment. A total 24 Sprague Dawley (SD) rats were included this study. Sixteen them 24-month natural-aged male SD rats, which randomly distributed into Aged group (n = 8 per group). The remaining 3-month -old used as Young positive control 8). Rats received 12 weeks 40 min/day, five days week, while other placebo intervention. Bone...
Abstract Age‐related thymic involution is a multifactorial process related to age‐related changes in intrathymic T‐cell development and cytokines. In contrast, early involution, because of genetic differences that cause rapid or slow at younger age, less well characterized. Here, we analysed three representative rapid‐involuting strains mice, BXD 8, 18 32, compared with slow‐involuting strains, 9, 19 29, all 2 months age. thymocyte production, as indicated by CD4 + CD8 receptor recombination...
Summary Systemic lupus erythematosus (SLE) is a complex immune disease. The genetic variation in the B lymphoid tyrosine kinase (BLK) gene was found to associate with SLE Caucasian population. However, association of rs13277113 and rs4840568 not extensively studied Chinese In this study, we aim test SNP disease risk mainland A total 532 patients 576 controls were recruited. Unlabelled probe‐based high‐resolution melting analysis (HRMA) used genotyping. HRMA unlabelled probe successfully...
Electroacupuncture (EA) has been clinically used in knee osteoarthritis broadly and proved to be effective than other therapies with fewer side effects; however, the mechanism of electroacupuncture work on cartilage remains unclear. In this study, we aimed evaluate effect EA treatment relationship between proteins such as HIF-a SOX9. (dilatational wave, 3–15 HZ, 1 mA) applied bilateral Zusanli (ST36), Xuehai (SP10), Taixi (KI3), Yanglingquan (GB34) rats. Results showed that group had obvious...
Background. Systemic lupus erythematosus (SLE) is a complex immune disease. The genetic variation in the IL-12b gene was found to associate with SLE Caucasian population. In this study, we examined association Chinese Han population by recently developed method, unlabeled probe-based high resolution melting analysis. Methods. A total of 297 patients and 351 controls were recruited. Unlabeled analysis (HRMA) used genotyping. Results. Statistically significant differences observed both...
The present paper proposes a new approach for fitting the plasma effect-site equilibrium rate constant (Ke0) of propofol to satisfy condition that concentration (Ce) is equal at time loss consciousness (LOC) and recovery (ROC). Forty patients receiving intravenous anesthesia were divided into 4 groups injected 1.4, 1.6, 1.8, or 2 mg/kg 1200 mL/h. Durations from start injection LOC ROC recorded. defined as an observer’s assessment alertness sedation scale change 3 3, respectively. Software...
Objective: To discuss the prevalence and influential factors of stroke among population in Jiangxi Province. Methods: Four cities urban areas four counties rural were selected firstly, which two districts or townships selected; then three communities villages chosen from each district township, respectively, using simple random sampling (SRS) method. Finally 15 269 subjects aging years old above, living Province ≥6 months randomly to participate this survey November 2013 August 2014....
<h3>Background</h3> Abnormal selection of self-reactive B cells has been shown to occur at the transitional cell stage, tolerance checkpoint II, in systemic lupus erythematosus (SLE). This study investigated novel mechanisms IFN-beta (IFNb)-dependent loss cells. <h3>Materials and methods</h3> Using a La-peptide specific tetramer, La13-27 autoreactive from spleens B6 autoimmune BXD2 mice were analysed for development CD93+ subsets. Mice treated with IFNa, IFNb, or anti-IFNAR induce block type...
<h3>Background</h3> Dysregulated responses to type I interferons (IFNs) is a hallmark of autoreactive B cell development in SLE patients. High sera levels IFN protein were recently shown occur the absence increased circulating pDCs and pDC IFNs, suggesting likelihood other important sources that may act on cells. The present study determined cellular source IFNβ its association with disease activities SLE. <h3>Methods</h3> Peripheral blood mononuclear cells (PBMCs) obtained from 31 patients...
Top of pageAbstract Respiratory viral infection is a major cause morbidity and mortality in the elderly population. IL-12 other Th1 cytokines can prevent age-related defect cytotoxic T lymphocyte (CTL) response by blocking age-associated down modulation CD28 immune senescence CD8+ cells. Gene therapy one method to restore defective reverse senescence. However, effect on generation effector function epitope-specific CD8 cells (CTLs) after delivery an adenovirus vector has been difficult...
Backgrounds: Allergic rhinitis (AR) is highly prevalent worldwide, but its treatment poor. Myofascial trigger point (MTrP) injections have been effectively used for the management of many chronic painful diseases. Latent MTrPs (we called Qi points, QiPs) could be with autonomic nerve phenomena. Little known about correlation between QiPs and AR. Therefore, we proposed hypothesis that might play a role in pathophysiological mechanisms The current study was designed to investigate efficacy...