A5043787630- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Lung Cancer Treatments and Mutations
- Head and Neck Surgical Oncology
- Flame retardant materials and properties
- Telomeres, Telomerase, and Senescence
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vitamin D Research Studies
- Transition Metal Oxide Nanomaterials
- Pancreatic function and diabetes
- Nutrition and Health in Aging
- Bone and Joint Diseases
- Bone health and osteoporosis research
- Bone health and treatments
- Liver Disease and Transplantation
- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- Wind and Air Flow Studies
- Urban Heat Island Mitigation
- Cerebrospinal fluid and hydrocephalus
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Occupational exposure and asthma
- Aerogels and thermal insulation
- Cancer Genomics and Diagnostics
- Air Quality and Health Impacts
Mount Sinai Hospital
2024
Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality
2022-2023
First Hospital of Jilin University
2015-2023
Jinan University
2022-2023
Jilin University
2015-2023
Nanjing Drum Tower Hospital
2023
NYU Langone Health
2022-2023
Nanjing University of Chinese Medicine
2023
Prevention Institute
2012-2022
Augusta University
2013-2022
OBJECTIVE Elevated glycolytic enzymes in renal glomeruli correlated with preservation of function the Medalist Study, individuals ≥50 years type 1 diabetes. Specifically, pyruvate kinase M2 (PKM2) activation protected insulin-deficient diabetic mice from hyperglycemia-induced glomerular pathology. This study aims to extend these findings a separate cohort and 2 diabetes discover new circulatory biomarkers for protection through proteomics metabolomics Medalists’ plasma. We hypothesize that...
Although clinical studies have shown the possible relationship between Helicobacter pylori (H. pylori) infection and development of nonalcoholic fatty liver disease (NAFLD), their causal is still unknown. This bidirectional Mendelian randomization (MR) study aimed to investigate link H. NAFLD. Two previously reported genetic variants SNPs rs10004195 rs368433 were used as instrumental variables (IVs) infection. The NAFLD extracted from largest genome-wide association (GWAS) summary data with...
Emerging evidence suggests that epigenetics regulates telomere dynamics in adults. However, the relationship between these pathways children and youth remains unknown. Thus, we examined this association 542 healthy adolescents aged 14 to 18 years old (44.8% African Americans; 55.2% females). Global DNA methylation level (%5-mC) was quantified using ELISA method. Leukocyte length (LTL) defined as relative single copy gene (T/S) ratio. Multiple linear regression models, adjusted for age,...
Liver inflammation and the immune response have been recognized as critical contributors to cirrhosis pathogenesis. Immunity-related genes (IRGs) play an essential role in cell infiltration reactions; however, changes microenvironment expression of IRGs involved remain unclear. CD45+ liver single-cell RNA (scRNA) sequencing data (GSE136103) from patients with were analyzed. The clusters identified known types through marker according previous studies. GO KEGG analyses among differentially...
A critical need exists to better understand the physiological sequel of vitamin D supplementation in obese individuals and African Americans. The aim was comprehensively evaluate dose- time-responses a panel biomarkers supplements this population.We conducted 16-week randomized, double-blinded, placebo-controlled clinical trial. Seventy overweight/obese Americans (age 13-45 years, 84 % females) with 25-hydroxyvitamin [25(OH)D] concentrations ≤20 ng/mL were randomly assigned receive...
Diabetes is a growing epidemic worldwide and requires effective clinical therapies. In recent years, β-cell transplantation has emerged as promising treatment for diabetes, an encapsulation approach been proposed to ameliorate this treatment.
Mesoporous TiO<sub>2</sub>–Cs<sub>x</sub>WO<sub>3</sub>particles with NIR shielding and photocatalytic properties were prepared<italic>in situ</italic>by a template-free method.
Background: Adult studies have suggested that magnesium intake may regulate C-reactive protein (CRP) and muscle mass, known risk factors for cardiometabolic diseases. Given the large deficiencies in adolescents, we aimed to investigate sex race differences dietary test hypothesis lower is associated with higher CRP mass. Methods: A total of 766 black white 14 18 years old (51% black; 50% female) were previously recruited. Diet was assessed four seven independent 24-h recalls. Body...
Abstract Background Inflammatory osteolysis is a severe infectious bone disorder that occurs during orthopaedic surgery and caused by disruptions in the dynamic balance of matrix homeostasis, which makes this condition burden on surgical procedures. Developing novel therapeutic drugs about inhibiting excessive osteoclastogenesis acts as an efficient approach to preventing inflammatory destruction. Methods To study this, we explored potential effects mechanisms compound 17 vitro. Meanwhile,...
Abstract Background and Aim Hepatic fibrosis is a common pathogenic outcome of almost all chronic liver diseases growing public health problem globally. However, the key genes or proteins driving cirrhosis are not well understood. We aimed to identify novel hepatic human primary stellate cells (HSCs). Methods Human HSCs were isolated from surgically resected advanced tissues ( n = 6) surgical resection normal tissue around hemangioma 5). Differences in expression levels mRNA group control...
Two soluble and stable diazapentacene derivatives were synthesized. DFT calculations their chemical properties indicate that both compounds have potential application as ambipolar semiconductors.