A5081488669- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Cancer Genomics and Diagnostics
- Parasitic Infections and Diagnostics
- Colorectal Cancer Screening and Detection
- Parasitic infections in humans and animals
- Traditional Chinese Medicine Studies
- Berberine and alkaloids research
- Hepatitis B Virus Studies
- Phosphodiesterase function and regulation
- Pediatric Hepatobiliary Diseases and Treatments
- Biochemical and Molecular Research
- Liver physiology and pathology
- Liver Diseases and Immunity
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- Urological Disorders and Treatments
- Machine Learning in Bioinformatics
- Organ Transplantation Techniques and Outcomes
- Nutrition, Genetics, and Disease
- Health and Medical Research Impacts
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Colorectal Cancer Treatments and Studies
Zhejiang Chinese Medical University
2025
Liaoning University of Traditional Chinese Medicine
2025
First Hospital of Jilin University
2021-2024
Jilin University
2021-2024
Beijing Institute of Genomics
2015
Abstract Background Observational studies have indicated that the incidence of primary biliary cholangitis (PBC) is higher in inflammatory bowel disease (IBD) patients than healthy people. However, whether correlation causal remains unclear. Methods The genetic associations with IBD were obtained from publicly available genome‐wide association (GWAS) European ancestry 31 665 cases and 33 977 controls, consisting 17 897 Crohn's (CD) 13 768 ulcerative colitis (UC) cases. PBC a GWAS 2764 10 475...
Background Postoperative cognitive impairment is a common complication in older patients after major orthopedic surgery; however, the underlying mechanism not completely understood. Objective This study aimed to evaluate effects of preemptive acupuncture on dysfunction hip replacement and explore its potential mechanisms. Methods Finally, 54 participants were randomized into sham ( n = 27) or groups, who received at Sishencong (EX-HN1) Baihui (DU20) acupoints, while acup group target...
Celery ( Apium graveolens L. ) seeds, derived from the herbaceous plant of Apiaceae family, are valued for both their culinary and medicinal applications. These seeds utilized as a flavoring agent in various cultures also employed traditional therapies to address range ailments. Rich trace elements petroselinic acid, celery possess significant nutritional value. Additionally, they contain variety bioactive compounds demonstrate broad spectrum pharmacological activities. Topically, can act...
Abstract Background and Aim Hepatic fibrosis is a common pathogenic outcome of almost all chronic liver diseases growing public health problem globally. However, the key genes or proteins driving cirrhosis are not well understood. We aimed to identify novel hepatic human primary stellate cells (HSCs). Methods Human HSCs were isolated from surgically resected advanced tissues ( n = 6) surgical resection normal tissue around hemangioma 5). Differences in expression levels mRNA group control...
Introduction Prompt detection of hepatocellular carcinoma (HCC) in patients with chronic liver diseases is critical for enhancing prognosis. Existing imaging techniques and serum markers fall short clinical needs. This study aims to establish a non-invasive diagnostic model early HCC the Chinese population. Methods analysis prospective, multicentre, observational will enrol 2000 participants, including patients, those (hepatitis, cirrhosis benign space-occupying lesions), healthy...
Tacrolimus (Tac) is an immunosuppressant that widely used to prevent allograft rejection in patients after liver transplantation. Its metabolism mainly depends on the cytochrome P450 3A5 (CYP3A5), which has genetic polymorphisms. Recently, a Chinese herbal medicine known as Wuzhi Capsule (WZC) was shown increase Tac blood concentrations by inhibiting activity of CYP3A animal studies rats. To date, it remains unexplored whether WZC can be efficiently enhance concentration transplant with...
Cystic echinococcosis (CE), caused by the cestode Echinococcus granulosus , is a worldwide chronic zoonosis. Albendazole (ABZ) and mebendazole are effective against CE, but high dosage in long-term period usually required. In this study, we evaluate effects of DNA damage repair inhibitor (i.e., Veliparib) combination with artesunate (AS) on hydatid cysts. For vitro assay, protoscoleces E. ( E.g PSCs) were incubated low AS (AS-L, 65 μ M), moderate (AS-M, 130 (AS-H, 325 AS-L/M/H+Veliparib (10...
<title>Abstract</title> <bold>Background and aim</bold> There have been previous recent studies generating conflicting findings on effect of phosphodiesterase 5 (PDE5) inhibitors with CHD, Diabetes, breast cancer prostatic cancer. Since we intended to use naturally occurring variation in genes encoding PDE5 investigate association between genetically proxied them. <bold>Method</bold> We used drug target mendelian randomization as main analytical method. 60,801 cases 123,504 controls from 48...
Abstract Background/Aims: Tacrolimus (Tac) is an immunosuppressant that widely used to prevent allograft rejection in patients after liver transplantation. Recently, a Chinese herbal medicine known as Wuzhi Capsule (WZC) was shown increase Tac blood concentrations by inhibiting the activity of CYP3A5 animal studies rats. To date, it remains unexplored whether WZC can be reduce dose requirement for transplant with different donor-recipient genotypes. Materials and Methods: A total 185 were...