A5100672620- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Hepatitis C virus research
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Neuroendocrine Tumor Research Advances
- SARS-CoV-2 and COVID-19 Research
- Clostridium difficile and Clostridium perfringens research
- Pediatric health and respiratory diseases
- Respiratory Support and Mechanisms
- T-cell and B-cell Immunology
- Iron Metabolism and Disorders
- COVID-19 Clinical Research Studies
- Healthcare Systems and Reforms
- MRI in cancer diagnosis
- Folate and B Vitamins Research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Hippo pathway signaling and YAP/TAZ
- Cancer, Stress, Anesthesia, and Immune Response
Tianjin Third Central Hospital
2014-2025
Tianjin Medical University
2016-2025
Nankai University
2022-2025
Tianjin First Center Hospital
2024-2025
Fujian Medical University
2024
Xiamen University
2024
Zhongda Hospital Southeast University
2024
Tianjin Medical University Cancer Institute and Hospital
2024
China West Normal University
2024
Qinghai University Affiliated Hospital
2023
Abstract Introduction Among various lupus renal vascular changes, thrombotic microangiopathy (TMA) presented with the most severe clinical manifestations and high mortality. The pathogenesis of TMA in systemic erythematosus (SLE) was complicated. aim this study to assess manifestations, laboratory characteristics, pathological features risk factors for outcomes nephritis patients co-existing a large cohort China. Methods Clinical histopathological data 148 biopsy-proven were retrospectively...
The research intended to present prospective data on the long-term prognosis of individuals with hepatitis C virus (HCV) infection who received direct-acting antiviral agent (DAA) treatment. Patients DAA treatment at Tianjin Third Central Hospital and Second People's were prospectively enrolled subsequently underwent a longitudinal follow-up. This monitored occurrences virological relapse, hepatocellular carcinoma (HCC), mortality, liver disease progression. annualized incidence rates...
Treating Helicobacter pylori (H. pylori) infection requires large quantities of antibiotics, thus dramatically promoting the enrichment and dissemination antimicrobial resistance (AMR) in feces. However, influence H. eradication on AMR mobility gut microbiota evolution has yet to be thoroughly investigated. Here, a study involving 12 pylori-positive participants was conducted, pre- post- fecal samples were sequenced. Metagenomic analysis revealed that treatment drastically altered...
To investigate the mechanism of autophagy in regulating bacterial translocation intestinal infection caused by hypervirulent Klebsiella pneumonia (hvKp) and explore method reducing bacteria. Fifty C57BL/6J mice were divided into gavage group (n = 40) control (CO group, n 10). The was orally administered with 200 μL/d hvKp (colony count 109 CFU/mL) continuously for 5 days to establish a model. CO given an equal amount normal saline. After experiment, anesthetized lsofluraneand euthanized...
Conflicting results have been obtained for the association between two common polymorphisms (C282Y, H63D) of human HFE (hereditary hemochromatosis) gene and risks liver diseases, including non-alcoholic fatty disease (NAFLD), cirrhosis hepatocellular carcinoma (HCC).An updated systematic review meta-analysis was conducted to evaluate potential role in susceptibility NAFLD, HCC. After retrieving articles from online databases, eligible studies were enrolled according selection criteria....
Thermal ablation can evoke an immune response, which may have effects on the prognosis of patients with hepatocellular carcinoma (HCC). Our aim is to investigate changes circulating T-cell subsets after microwave (MWA) and explore risk factors tumor recurrence in hepatitis B virus (HBV)-related HCC.Thirty HBV-related HCC were enrolled this study. The blood samples collected both before MWA (24 h, 72 1 month MWA). distributions Th17 cells, regulatory Treg-cells, CD4+ T-cells, CD8+ CD3+...
Recent studies have shown that imbalance between tumor-infiltrating interleukin (IL)-17(+) T cells and regulatory (Tregs) is an important regulator of progression in various cancers, but little known regarding this hepatocellular carcinoma (HCC). This study explored the role IL-17(+) Tregs immunopathogenesis HCC patients with chronic hepatitis B (CHB) infection.Fifty-six patient-matched tumors peritumoral surgical specimens from 56 patient 136 liver biopsies 46 CHB, 37 atypical hyperplasia...
Autophagy has a significant role in myocardial injury induced by lipopolysaccharide (LPS). Estrogen (E2) been demonstrated to protect cardiomyocytes against apoptosis; however, it remains be determined whether exhibits anti‑autophagic effects. The aim of the present study was investigate estrogen-regulated autophagy attenuates cardiomyocyte LPS. neonatal rats were randomized control (Con), LPS and estrogen + groups. group treated with 1 µg for 24 h 10‑8 M 30 min prior treatment Cardiomyocyte...
We aimed to investigate sleep quality, mild hepatic encephalopathy, anxiety, and depression in patients with hepatitis B cirrhosis by using a variety of scales questionnaires.A cohort 341 liver were categorized Child-Pugh grading (A, B, C) this cross-sectional study. Pittsburgh Sleep Quality Index (PSQI), Number Connection Test-A (NCT-A), Hospital Anxiety Depression (HAD) evaluated the questionnaires statistically analyzed intrinsic correlation. The control group included 50 healthy...
Cinobufagin, a cardiotonic steroid derived from toad venom extracts, exhibits significant anticancer properties by inhibiting Na[Formula: see text]/K[Formula: text]-ATPase in cancer cells. It is frequently used clinical settings to treat advanced-stage patients, improving their quality of life and survival time. However, its long-term use can result multidrug resistance other chemotherapy drugs, the exact mechanism underlying this effect remains unknown. Therefore, study explores molecular...
Aims. To develop a noninvasive score model to predict NASH in patients with combined CHB and NAFLD. Objective Methods. 65 NAFLD were divided into group (34 patients) non-NASH (31 according the NAS score. Biochemical indexes, liver stiffness, Controlled Attenuation Parameter (CAP) determined. Data two groups compared subjected multivariate analysis, establish for prediction of NASH. Results. In group, ALT, TG, fasting blood glucose (FBG), M30 CK-18, CAP, HBeAg positive ratio significantly...
Emergency endoscopy is recommended for patients with acute esophageal variceal bleeding (EVB) and their prognosis has improved markedly over past decades due to the increased specialization of endoscopic practice. The study aimed compare outcomes following emergency injection sclerotherapy (EIS) ligation (EVL) in cirrhotic EVB.Cirrhotic EVB who underwent were retrospectively enrolled from 2013 2020 across 34 university hospitals 30 cities. primary outcome was incidence 5-day rebleeding after...
Abstract Background & Aims To explore the long‐term outcomes and safety of ultrasound‐guided percutaneous microwave ablation ( MWA ) exophytic tumours in hepatocellular carcinoma HCC patients. Methods One hundred thirty‐two patients with subcapsular were enrolled this retrospective study. These divided into group (n=71) non‐exophytic (n=61) according to location tumour(s). A special technology puncture was performed treat tumours. The local tumour progression LTP ), free survival PFS...
The liver is essential for the regulation of energy, protein and amino acids, as well in other aspects metabolism. To identify efficient indexes evaluation nutritional status metabolic characteristics during different Child-Pugh stages hepatitis B cirrhosis, 83 patients 35 healthy individuals were enrolled our study. We found that grip strength, triceps skinfold thickness (TSF), body fat skeletal muscle reduced compared to control group (P<0.05). Ultra-high-performance liquid chromatography...