A5101894750- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Tracheal and airway disorders
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Xenotransplantation and immune response
- Hematopoietic Stem Cell Transplantation
- RNA Interference and Gene Delivery
- Liver Disease and Transplantation
- Nanoparticle-Based Drug Delivery
- Mesenchymal stem cell research
- Liver physiology and pathology
- Drug Transport and Resistance Mechanisms
- Tea Polyphenols and Effects
- Congenital Diaphragmatic Hernia Studies
- Organ and Tissue Transplantation Research
- Pharmacogenetics and Drug Metabolism
- Cardiovascular Effects of Exercise
- Tissue Engineering and Regenerative Medicine
- Immune cells in cancer
- Medical Research and Treatments
- Cancer, Hypoxia, and Metabolism
First Hospital of Jilin University
2020-2025
Jilin University
2020-2025
Zhejiang Chinese Medical University
2025
Tongde Hospital of Zhejiang Province
2024-2025
Yahoo (United Kingdom)
2023-2024
Xi'an International Studies University
2022
Ludwig-Maximilians-Universität München
2017
Abstract Combining intracellularly active proteins with chemotherapeutics represents a promising strategy for synergistic cancer therapy. However, the lack of nanocarrier systems delivery into cells and controlled intracellular release both physicochemically very distinct cargos significantly impedes biomedical translation this combination in Here, well‐designed triblock copolymer, mPEG‐ b ‐PGCA‐ ‐PGTA, is reported application multistage cooperative drug nanoplatform that accomplishes...
Abstract OBJECTIVES Tracheal reconstruction post-extensive resection remains an unresolved challenge in thoracic surgery. This study evaluates the use of aortic allografts (AAs) for tracheal replacement and a rat model, aiming to elucidate underlying mechanisms regeneration. METHODS AAs from female rats were employed 36 male rats, with exceeding half length. To avert collapse, silicone stents inserted into AA lumens. No immunosuppressive therapy was administered. The euthanized biweekly,...
Microsecond pulsed electric field (µsPEF) is a newer treatment modality to replace catheter ablation of Atrial fibrillation (AF) due its fewer side effects. This study aims find out experimental parameters that effectively induce cardiomyocyte death and the precise mechanisms for microsecond fields (µsPEFs) cardiomyocytes. CCK8 flow apoptosis analysis were employed examine effects different µsPEFs on cardiomyocytes in vitro. The by which works explored through combination transcriptome...
Natural killer T cells (NKTs) are innate-like lymphocytes that abundant in the liver and participate immunity. NKT express both NK cell markers, modulate innate adaptive immune responses. Type I II classified according to TCR usage, while they recognize lipid antigen a non-classical major histocompatibility (MHC) molecule CD1d-restricted manner. Once activated, can quickly produce cytokines chemokines negatively or positively regulate responses, depending on different subsets. In...
Abstract Organ transplantation remains the most effective treatment for patients with late stage organ failure. Transgenic pigs provide an alternative donor source to limited availability of human organs. However, cellular rejection still be obstacle xenotransplantation. Superior other methods, antigen-specific regulatory T cells (Treg) alleviate fewer side effects. Here we demonstrate use a fast method tolerogenic dendritic (tolDC) that can used generate porcine-specific Treg (PSTreg)....
Abstract Background Regulatory T cells (Treg) play an important role in maintenance of homeostasis vivo. Treg application to alleviate allo‐organ rejection is being studied extensively. However, natural ( nT reg) expansion vitro laborious and expensive. Antigen‐specific are more effective require lower cell numbers than use reg for immune control. The baboon, as a non‐human primate experimental animal model, widely used xenotransplantation research. An method generate baboon xeno‐specific...
Graft-versus-host disease (GVHD) following liver transplantation is induced by the graft-versus-host (GVH) T cell that transferred with graft, but dynamics remain poorly investigated in clinical GVHD. Here, we report two recipients who developed GVHD, both of whom showed donor macrochimerism blood before GVHD onset. Longitudinal tracking GVH clones one these revealed clonal expansion occurred onset, and dominant cells might also derive from non-hepatic tissue-resident memory liver-graft....
Natural killer (NK) cells contribute to liver transplant (LTx) rejection. However, the blood-circulating NK-cell dynamics of patients who experience acute rejection (AR) are unclear. Herein, we longitudinally profiled total NK and their subsets, along with expression activating inhibitory receptors in sequential peripheral blood mononuclear cell samples, spanning from before LTx first year after 32 AR 30 under a steady immune status. Before transplantation, (rejectors) contained...
Tacrolimus (Tac) is an immunosuppressant that widely used to prevent allograft rejection in patients after liver transplantation. Its metabolism mainly depends on the cytochrome P450 3A5 (CYP3A5), which has genetic polymorphisms. Recently, a Chinese herbal medicine known as Wuzhi Capsule (WZC) was shown increase Tac blood concentrations by inhibiting activity of CYP3A animal studies rats. To date, it remains unexplored whether WZC can be efficiently enhance concentration transplant with...
The purpose is to automatically and quickly analyze whether the rope skipping actions conform standards give correct guidance training plans. Firstly, aiming at problem of motion analysis, a deep learning (DL) framework proposed obtain coordinates key points in skipping. based on OpenPose method uses lightweight MobileNetV2 instead Visual Geometry Group (VGG) 19. Secondly, multi-label classification model proposed: attention long short-term memory-long memory (ALSTM-LSTM), according...
T cells are key mediators of alloresponse during liver transplantation (LTx). However, the dynamics donor-reactive T-cell clones in peripheral blood a clinical T-cell-mediated rejection (TCMR) episode remain unknown. Here, we collected serial mononuclear cell samples spanning from pre-LTx to 1 year after LTx and available biopsies TCMR episodes 26 rejecting patients, were 96 nonrejectors. Immunophenotypic repertoire analyses integrated on rejectors, they longitudinally compared nonrejected...
<title>Abstract</title> Background Hematopoietic stem and progenitor cells (HSPCs) mobilize from bone marrow to peripheral blood in response stress. The impact of alloresponse-induced stress on HSPCs mobilization human liver transplantation (LTx) recipients remains under-investigated. Methods Peripheral mononuclear cell (PBMC) samples were longitudinally collected pre- post-LTx for one year 36 with acute rejection (AR), 74 without (NR), 5 graft-versus-host disease (GVHD). 28 PBMC age-matched...
Abstract Background Hematopoietic stem and progenitor cells (HSPCs) mobilize from bone marrow to peripheral blood in response stress. The impact of alloresponse-induced stress on HSPCs mobilization human liver transplantation (LTx) recipients remains under-investigated. Methods Peripheral mononuclear cell (PBMC) samples were longitudinally collected pre- post-LTx for one year 36 with acute rejection (AR), 74 without (NR), 5 graft-versus-host disease (GVHD). 28 PBMC age-matched healthy donors...