A5067058714- Antibiotic Resistance in Bacteria
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Structural Anomalies and Repair
- Bacterial biofilms and quorum sensing
- Infective Endocarditis Diagnosis and Management
- Cardiac tumors and thrombi
- Bacteriophages and microbial interactions
- Infections and bacterial resistance
- Pharmaceutical and Antibiotic Environmental Impacts
- Aortic Thrombus and Embolism
- Plant Pathogenic Bacteria Studies
- Cardiovascular Effects of Exercise
- Bacterial Genetics and Biotechnology
- TiO2 Photocatalysis and Solar Cells
- Salmonella and Campylobacter epidemiology
- Mycobacterium research and diagnosis
- Cardiac electrophysiology and arrhythmias
- Trauma Management and Diagnosis
- Foreign Body Medical Cases
- Hippo pathway signaling and YAP/TAZ
- Kruppel-like factors research
- Photochromic and Fluorescence Chemistry
- Microbial Inactivation Methods
Zhejiang University
2021-2025
Inner Mongolia Medical University
2024
Southwest Medical University
2020-2024
First Affiliated Hospital Zhejiang University
2020-2024
Zhejiang University-University of Edinburgh Institute
2024
Shenzhen University
2021-2023
East China University of Science and Technology
2023
National Institute for Communicable Disease Control and Prevention
2018-2021
Ocean University of China
2021
Southwest Jiaotong University
2021
Tick-borne encephalitis virus (TBEV) has been classified into three subtypes, namely the European (Eu-TBEV), Far Eastern (FE-TBEV), and Siberian (Sib-TBEV). In this study, we discovered a new subtype of TBEV in wild rodent Marmota himalayana Qinghai-Tibet Plateau China, proposed as Himalayan (Him-TBEV). Two complete genomes were obtained from respiratory samples 200 marmots. The phylogenetic analysis using E protein polyprotein demonstrated that two strains Him-TBEV formed an independent...
Abstract The emergence and spread of mobilized colistin resistance ( mcr ) genes have triggered extensive concerns worldwide. Here, we characterized the global distribution mcr-9 , a newly-identified variant by assembling data set -positive isolates from GenBank database literature available. Genetic features all -harboring plasmids were determined bioinformatic analysis. We showed that is globally distributed in 21 countries across six continents, with wide dissemination among various...
Shear stress exerted by the blood stream modulates endothelial functions through altering gene expression. KLF2 and KLF4, mechanosensitive transcription factors, are promoted laminar flow to maintain homeostasis. However, how expression of KLF2/4 is regulated shear poorly understood. Here, we showed that activation PIEZO1 upregulates in cells. Mice with endothelial-specific deletion Piezo1 exhibit reduced thoracic aorta pulmonary vascular Mechanistically, activates PIEZO1, which results a...
Bone cement embolism is one of major complications percutaneous kyphoplasty. Although rare, the intracardiac potentially life-threatening, with a documented incidence 3.9%, and it even more infrequent if symptomatic (0.3%). Herein, we reported an extremely rare case bone after kyphoplasty causing right ventricle perforation. A 70-year-old woman, experiencing sudden left chest pain radiation to shoulder for 9 h, was transferred our emergency department. Two hours before onset her symptoms,...
Microsecond pulsed electric field (µsPEF) is a newer treatment modality to replace catheter ablation of Atrial fibrillation (AF) due its fewer side effects. This study aims find out experimental parameters that effectively induce cardiomyocyte death and the precise mechanisms for microsecond fields (µsPEFs) cardiomyocytes. CCK8 flow apoptosis analysis were employed examine effects different µsPEFs on cardiomyocytes in vitro. The by which works explored through combination transcriptome...
The emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) has driven us to explore alternative treatments for the limitation antimicrobial agents. Lytic phages are considered a promising treatment CR-hvKP infection. In this study, we reported three novel lytic phages, vB_KpnA_SCNJ1-Z, vB_KpnS_SCNJ1-C, and vB_KpnM_SCNJ1-Y, against strain SCNJ1, they possess genomes double-stranded DNA with size 43,428 bp, 46,039 50,360 respectively. Phylogenetic analysis demonstrated...
Abstract Raoultella planticola is an emerging pathogen causing several infections in humans, and its roles the propagation of antibiotic resistance genes (ARGs) remain uncharacterized. In this study, a carbapenem tigecycline-resistant R. isolate was recovered from hospital sewage. It carried nine plasmids, bearing 30 ARGs, including one bla KPC-2 two NDM-1 . also contained plasmid-borne efflux pump gene cluster, tmexCD1-toprJ , conferring to tigecycline. Analysis plasmid sequences revealed...
Observational studies have reported an inverse association of type 2 diabetes (T2D) with thoracic aortic aneurysm (TAA). However, the causality has not been established yet. The present study aims to clarify causal relationship between T2D and TAA via a Mendelian randomization (MR) approach.Causality associations were assessed using two-sample MR framework. Genome-wide (GWAS) summary statistics obtained for T2D, glycated hemoglobin (HbA1c), fasting glucose (FG) insulin (FI) as exposures,...
Multidrug-resistant (MDR) Proteus, especially those strains producing extended-spectrum β-lactamases (ESBL) and carbapenemases, represents a major public health concern. In the present work, we characterized 27 MDR Proteus clinical isolates, including 23 mirabilis, three terrae, one faecis, by whole-genome analysis. Among isolates analyzed, SXT/R391 ICEs were detected in 14 strains, complete sequences of nine obtained. These share common backbone structure but also have different gene...
Esophageal cancer micro environment factor WNT2 was critical in metastasis. However, very little is known about receptors and their role the malignant progression of ESCC. The clinical significance underlying molecular mechanisms FZD2, one WNT2, further investigated We found that FZD2 expression positively correlated with levels ESCC specimens through database analysis. Upregulated detected 69% (69/100) primary cases examined, increased significantly poor prognosis (P < 0.05)....
Citrobacter freundii is an important opportunistic pathogen, and carbapenem-resistant strains pose a significant challenge to public health. Here we report the genetic features of antimicrobial resistance genes C. SCLZS47 from hospital sewage by using whole genome sequencing.Antimicrobial susceptibility was determined broth microdilution method. Whole genomic sequences were obtained HiSeq 2000 combined with PacBio RSII platforms. Plasmid incompatibility types, genes, insertion elements...
Proteus mirabilis is the one of most important pathogens catheter-associated urinary tract infections. The emergence multidrug-resistant (MDR) P. severely limits antibiotic treatments, which poses a public health risk. This study aims to investigate resistance characteristics and virulence potential for collection clinical isolates.Antibiotic susceptibility testing revealed fourteen MDR strains, showed high β-lactams trimethoprim/sulfamethoxazole, lesser extent quinolones. All strains were...
Hypervirulent
Three NDM-5-producing Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, and Citrobacter braakii, one each) were isolated during a screening study for the presence of carbapenemase-producing (CPE) strains in urban rivers China. The aim present was to characterize these isolates by using whole-genome analysis.In vitro susceptibility testing performed broth microdilution method. Conjugation assay carried out investigate transferability blaNDM-5-harboring plasmids. Whole-genome...
Tricuspid regurgitation after left-sided valve surgery was associated with terrible outcomes and high perioperative mortality for surgical treatment. In current years, minimally invasive isolated tricuspid repair is increasingly performed in our institution to address regurgitation.Thirty-seven consecutive patients previous underwent between November 2017 December 2020. Twenty-nine patients(78.4%) were women the mean age of 58.4 ± 8.5 years. Follow-up 100% complete a follow-up time 17.2 9.5...
Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a serious threat to public health due limited antibiotic therapy options.1 KPC-2-producing K. strains have now spread worldwide and are highly prevalent in China.2 Dissemination of the blaKPC-2 gene is commonly associated with clonal group 258 (CG258), especially transmissible ST11 clone, various types plasmids.2,3 IS26 frequently horizontal dissemination resistance determinants, including blaKPC-2.4 In this study, we isolated two...
Background: The relationship of body mass index (BMI) to short- and long-term outcomes after cardiac surgery remains controversial, the dose-response between BMI mortality in patients receiving is unclear. Furthermore, influence age, concomitant disease, types on prognostic role has yet be determined.
Timely acquisition of spatial flood distribution is an essential basis for flood-disaster monitoring and management. Remote-sensing data have been widely used in water-body surveys. However, due to the cloudy weather complex geomorphic environment, inability receive remote-sensing images throughout day has resulted some being missing unable provide dynamic continuous inundation process data. To fully effectively use data, we developed a new decision support system integrated management based...
The emergence of carbapenem-resistant Proteus represents a serious threat to global public health due limited antibiotic treatment options. Here, we characterize isolate NMG38-2 swine origin that exhibits extensive drug resistance, including carbapenems. Whole-genome sequencing based on Illumina and MinION platforms showed contains 24 acquired resistance genes three plasmids, among which, pNDM_NMG38-2, pPvSC3-like plasmid, is transferable co-carries blaNDM-1 lnu(G). Sequence analysis...