A5076457381- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Mesenchymal stem cell research
- Infective Endocarditis Diagnosis and Management
- Angiogenesis and VEGF in Cancer
- Cardiac and Coronary Surgery Techniques
- Congenital Heart Disease Studies
- Coronary Artery Anomalies
- Cardiac tumors and thrombi
- Cardiac Arrest and Resuscitation
- Trauma Management and Diagnosis
- Cardiac Imaging and Diagnostics
- Cardiovascular and Diving-Related Complications
- Restraint-Related Deaths
- Diabetic Foot Ulcer Assessment and Management
- Tissue Engineering and Regenerative Medicine
- Congenital heart defects research
- Cardiac Fibrosis and Remodeling
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood transfusion and management
- Genomics, phytochemicals, and oxidative stress
- Osteoarthritis Treatment and Mechanisms
- Aortic Disease and Treatment Approaches
First Affiliated Hospital Zhejiang University
2014-2025
Zhejiang University
2013-2025
Affiliated Hospital of Hebei University
2023
Houston Methodist
2014
Indiana University Health
2014
Indiana University – Purdue University Indianapolis
2014
Methodist Hospital
2013-2014
Novem (Netherlands)
2014
Yangon University of Economics
2013
Johns Hopkins University
2008-2009
Introduction: Aortic aneurysm is a life-threatening disease resulted from progressive dilatation of the aorta, which can be subdivided into thoracic and abdominal aortic aneurysms. Sustained subcutaneous angiotensin II infusion induce aneurysms in mice. However, relevance using induction model to study degree commonality between species remain elusive. Methods: We utilized scRNA-seq infer cell sub-structures transcriptional profiles clinical patient TAAs AAAs, as well mouse models...
Abstract Objectives To investigate effects of TiO 2 nanotubes different diameters on J744A.1 macrophage behaviour, secretion and expression pro‐inflammatory cytokines chemokines. Materials methods Macrophage‐like cells were cultured three types Ti surface: mechanically polished titanium plus 30 80 nm nanotube surfaces, for 4, 24 48 h. Macrophage adhesion proliferation assessed using CCK ‐8 assay. Levels ( TNF ‐α, IL ‐1β ‐6) chemokines MCP ‐1 MIP ‐1α) secreted into the supernatant measured...
Abstract Data from clinical research and our previous study have suggested the potential involvement of SENP1, major protease post-translational SUMOylation, in cardiovascular disorders. Here, we investigate role SENP1-mediated SUMOylation graft arteriosclerosis (GA), cause allograft failure. We observe an endothelial-specific induction SENP1 GATA2 rejection specimens that show endothelial activation-mediated vascular remodelling. In mouse aorta transplantation GA models, knockout grafts...
Dextrocardia is a rare cardiac malposition where the heart's normal orientation reversed and most commonly associated with situs inversus totalis (SIT). Such cases are technically challenging when heart surgery needed, especially re-do surgery. A 72-year-old female patient was referred to our hospital complaints of chest tightness reduced activity tolerance. The had history mitral valve replacement (MVR) bioprosthesis ten years prior. Chest X-ray showed dextrocardia SIT in patient....
Bone cement embolism is one of major complications percutaneous kyphoplasty. Although rare, the intracardiac potentially life-threatening, with a documented incidence 3.9%, and it even more infrequent if symptomatic (0.3%). Herein, we reported an extremely rare case bone after kyphoplasty causing right ventricle perforation. A 70-year-old woman, experiencing sudden left chest pain radiation to shoulder for 9 h, was transferred our emergency department. Two hours before onset her symptoms,...
BACKGROUND: Myocardial infarction (MI) elicits mitochondria reactive oxygen species (ROS) production and cardiomyocyte (CM) apoptosis. Nrf3 (nuclear factor erythroid 2-related 3) has an established role in regulating redox signaling tissue homeostasis. Here, we aimed to evaluate the mechanism of injury-induced pathological cardiac remodeling. METHODS: Global (Nrf3-KO) CM-specific (Nrf3 △CM ) knockout mice were subjected MI or ischemia/reperfusion injury, followed by functional...
Rationale: Lymphangiogenesis plays a critical role in the transplanted heart.The remodeling of lymphatics heart and source newly formed lymphatic vessels are still controversial, especially mechanism lymphangiogenesis remains limited. Methods:Heart transplantation was performed among BALB/c, C57BL/6J, Cag-Cre, Lyve1-CreER T2 ;Rosa26-tdTomato Postn(2A-CreER -wpre-pA)1;Rosa26-DTA mice.scRNA-seq, Elisa assay, Western blotting, Q-PCR immunohistochemical staining were used to identify cells...
// Zhao Chen 1,* , Yiran Zhang Liang Ma 1 Yiming Ni and Haige Department of Cardiothoracic Surgery, The First Affiliated Hospital, School Medicine, Zhejiang University, Hangzhou, Zhejiang, China * These authors have contributed equally to this study Correspondence to: Zhao, email: Keywords : Nrf2, burn trauma, intestinal injury, systemic inflammation, Immunology Microbiology Section, Immune response, Immunity Received January 09, 2016 Accepted March 05, Published 18, Abstract Nuclear factor...
Although human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) are a promising cell resource for cardiovascular research, these cells exhibit an immature phenotype that hampers their potential applications. The inwardly rectifying potassium channel Kir2.1, encoded by the KCNJ2 gene, has been thought as important target promoting electrical maturation of iPSC-CMs. However, comprehensive characterization morphological and functional changes in iPSC-CMs overexpressing (KCNJ2 OE)...
Impairment of the thrombomodulin-protein C anticoagulant pathway has been implicated in pathological thrombosis associated with malignancy. Patients who receive proteasome inhibitors as part their chemotherapeutic regimen appear to be at decreased risk for thromboembolic events. We investigated effects on endothelial thrombomodulin expression and function.Proteasome a class markedly induced enhanced protein activating capacity cells. Thrombomodulin upregulation was independent NF-kappaB...
Background Acute rejection is a determinant of prognosis following kidney transplantation. It essential to search for novel noninvasive biomarkers early diagnosis and prompt treatment. Methods Gene microarray data was downloaded from the Expression Omnibus (GEO) expression profile database intersected differentially expressed genes (DEGs) calculated. We conducted DEGs with Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analysis. Distribution immune cell infiltration...
Prosthesis-patient mismatch (PPM) may affect the clinical outcomes of patients undergoing aortic valve replacement (AVR). We aimed to determine incidence PPM, its effect on short-term mortality, and factors contributing PPM in China.We retrospectively examined all consecutive with isolated or concomitant AVR at our hospital between January 1, 2013 December 31, 2015. was defined as an effective orifice area index (EOAi) ≤ 0.85 cm2/m2. The baseline, echocardiographic, operative, outcome data...
Prosthesis-patient mismatch (PPM) may affect the clinical outcomes of patients undergoing mitral valve replacement (MVR) surgery. We aimed to investigate incidence PPM position in our center and analyze possible predictors as well its effect on short-term outcomes.We retrospectively examined all consecutive with isolated or concomitant MVR at from 2013 2015. was defined an indexed effective orifice area (iEOA) ≤1.2 cm2/m2. After inclusion exclusion, a total 1067 were analyzed. The baseline...
PFA uses short-duration, high-voltage electrical pulses to induce transient or irreversible electroporation on cell membranes, causing death. Selective inhibition of chaotic signals in morbid cardiomyocytes significantly aids the treatment atrial fibrillation, ventricular tachycardia, and other heart arrhythmias. Recent preclinical clinical studies have only investigated physical changes, such as lesion size myocardial scar. Compared radiofrequency ablation cryoballoon ablation, causes less...
Acute kidney injury (AKI) after cardiac surgery is independently associated with a prolonged hospital stay, increased cost of care, and post-operative mortality. Delayed elevation serum creatinine (SCr) levels requires novel biomarkers to provide prediction AKI surgery. Our objective was find blood combination construct model for predicting risk stratification. This case-control study. Weighted Gene Co-expression Network Analysis (WGCNA) applied Expression Omnibus (GEO) dataset GSE30718 seek...
The prevalence of patent foramen ovale (PFO) is 20-25% among adults. role right-to-left shunting through the PFO in systemic hypoxemia remains poorly understood. Right-to-left can occur either due to elevated right atrial pressure (pressure-driven) or directed venous flow toward (flow-driven). Herein, we report a rare case flow-driven via patient with traumatic tricuspid regurgitation. A 45-year-old Chinese woman was admitted progressive dyspnea for 3 years, presenting cyanosis and digital...
Hemorrhagic shock (HS) following trauma or major surgery significantly contributes to mortality. However, the mechanisms through which HS activates inflammatory response are not yet fully understood. Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2), a bZIP transcription factor, is master regulator of robust cytoprotective defenses. The present study investigated role Nrf2 in pathophysiology HS. expression peripheral leukocytes obtained from patients with surgery-associated...
Abstract Rationale: Hemophilia A (HA) is an X-linked recessive disorder caused by clotting factor VIII (FVIII) deficiency. There limited data on the use of replacement therapy in cardiac surgery. Since no international guideline for anticoagulation such patient exists, careful thought should be taken to design individualized strategy. Patient concerns: We report a 54-year-old male with severe HA FVIII activity 0.8% when he was first diagnosed, who underwent successful mitral valve repair and...
We aimed to evaluate whether blood conservation strategies including intraoperative autologous donation (IAD) could reduce perioperative transfusion for patients undergoing cardiac valve replacement mitral replacement, aortic (AVR), and double (DVR). A total of 726 were studied over a 3-year period (2011–2013) after the implementation IAD compared with 919 during previous 36-month (January 2008–December 2010). The method small-volume retrograde priming, strict standard together constituted...