A5101963756- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Cancer Risks and Factors
- Cancer-related gene regulation
- Multiple and Secondary Primary Cancers
- Lung Cancer Treatments and Mutations
- Sex and Gender in Healthcare
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Behavioral Health and Interventions
- Diverticular Disease and Complications
- Hepatocellular Carcinoma Treatment and Prognosis
- Glutathione Transferases and Polymorphisms
- COVID-19 diagnosis using AI
- Medical Research and Treatments
- Endometrial and Cervical Cancer Treatments
- Genital Health and Disease
- Genomic variations and chromosomal abnormalities
- Mental Health Research Topics
- Dietary Effects on Health
Hangzhou Medical College
2020-2023
Zhejiang Academy of Medical Sciences
2017-2021
Zhejiang University
2009-2017
Methylated Septin9 (mSEPT9) has been suggested as a reliable biomarker in colorectal cancer (CRC) detection. We aimed to determine the diagnostic value of mSEPT9 for CRC detection Chinese patients. In addition, we compared efficacy traditional screening method [fecal occult blood test (FOBT)] and two biomarkers [carcinoembryonic antigen (CEA) carbohydrate antigen-199 (Ca-199)].Overall 248 subjects including 123 patients with 125 controls were included. Plasma fecal samples collected CEA,...
Background: The epidemiological feature of human papillomavirus (HPV) infection is distinctive in China. We aimed to investigate the multi-infection patterns and co-infection preference 27 HPV types among gynecological outpatients across Methods: Overall 137,943 were recruited from eight tertiary hospitals located seven regions China, between July 1st, 2014 December 31st, 2016. overall, region-specific, age-specific type-specific prevalence calculated, respectively. pattern was also...
Esophageal cancer micro environment factor WNT2 was critical in metastasis. However, very little is known about receptors and their role the malignant progression of ESCC. The clinical significance underlying molecular mechanisms FZD2, one WNT2, further investigated We found that FZD2 expression positively correlated with levels ESCC specimens through database analysis. Upregulated detected 69% (69/100) primary cases examined, increased significantly poor prognosis (P < 0.05)....
We aimed to provide a systematical evaluation of the performance period analysis compared traditional cohort and complete methods, using cancer registry data from Taizhou, eastern China. Overall, 5‐year relative survival (RS) estimate was calculated analysis, respectively; further analyses were stratified by sex, region, age at diagnosis sites. Deviation value (DV), defined as deviation between estimated RS obtained each method observed actual survival, evaluate accuracy method. derived much...
We aimed to explore the expression of miRNAs and their potential roles in DNA damage response (DDR) induced by Cr (VI) exposure human B lymphoblast cells (HMy2.CIR cells) a population (VI)-exposed humans.Differentially expressed were found combination miRNA sequencing RT-qPCR validation HMy2.CIR treated with K2Cr2O7. Differentially related DDR selected for functional study. The levels differential also investigated chromate workers.A total 214 differentially identified sequencing, 5 among 25...
Background: Investigation on prognostic markers for colorectal cancer (CRC) deserves efforts, but data from China are scarce. This study aimed to build a algorithm using differentially expressed gene (DEG) profiles and compare it with the TNM staging system in their predictive accuracy CRC prognosis Chinese patients. Methods: DEGs six paired tumor corresponding normal tissues were determined RNA-Sequencing. Subsequently, matched 127 patients assayed further validation. Univariate...
Introduction: FANCC is reported as a novel susceptibility gene for breast cancer, however, its mutation remains unclear in Chinese population. We aimed to identify the germline mutations of high-risk cancer patients China. Methods: 255 BRCA1/2-negative familial and/or ovarian (FBOC) were recruited screen. For whom 90 detected by PCR-sequencing assay, and another 165 98-gene panel sequencing assay. The assay was also used screen other possible with 250 sporadic (SBC) 248 female non-cancer...
The assessment of long-term survival lung cancer patients based on data from population-based caner registries, using period analysis, was scarce in China. We aimed to accurately assess the patients, and predict future, registry Taizhou City, eastern China.Four registries with high-quality were selected. Patients diagnosed during 2004-2018 included. evaluated further stratification by sex, age at diagnosis region. Additionally, projected 5-year relative (RS) for 2019-2023 evaluated,...
Abstract Introduction While timely assessment of long‐term survival for patients with colorectal cancer (CRC) is essential evaluation on early detection and screening programs cancer, those data are extremely scarce in China. We aimed to accurately assess CRC eastern Methods Patients diagnosed during 2004–2018 followed up until December 31, 2018 from four registries high‐quality Taizhou, China were included. Period analysis was used calculate 5‐year relative (RS) overall the stratification...
Objective: To evaluate the cost-effectiveness of colorectal cancer screening program in different age groups from view health economics. Methods: The compliance rates, detection rates were calculated by using data Jiashan county, Zhejiang province. differences indicator among analyzed with χ(2) test or trend test. ratios cost to number case according statistics. Results: immunochemical fecal occult blood (iFOBT) positivity, advanced adenoma and early stage increased age, while diagnosis...
As a newly described member of the apolipoprotein gene family, A5 (APOA5) has been suggested to play key role in triglyceride metabolism both human and mice. The aim this study was identify porcine (Sus scrofa) APOA5 gene, determine its mRNA mutations that are associated with lipid accumulation. cDNA amplified by reverse transcriptase polymerase chain reaction using information mouse or other mammals. It had determined open reading frame consists 1092 bp, which encodes predicted protein...
Introduction While timely assessment of long-term survival for patients with liver cancer is essential the evaluation early detection and screening programs cancer, those data are extremely scarce in China. We aimed to accurately assess eastern Methods Patients diagnosed during 2004–2018 from four registries high-quality Taizhou, China, were included. The period analysis was used calculate 5-year relative (RS) overall stratification by sex, age at diagnosis, region. projected RS 2019–2023...
Abstract Since the COVID-19 outbreak began, a large number of studies have been conducted in short period. However, it is unclear whether countries involved this crisis made adequate efforts and allocated resources to cutting-edge SARS-CoV-2 research. We analyzed dynamics professional fields represented by papers about novel coronavirus published before June 15, 2020. High-infection produced more scientific output than low-infection countries, high-income upper-middle-income were main...
Abstract Background: Investigation on prognostic markers for colorectal cancer (CRC) deserves efforts, but data from China are scarce. This study aimed to build a algorithm using differentially expressed gene (DEG) profiles and compare it with the TNM staging system in their predictive accuracy Chinese CRC prognosis. Methods: DEGs six-paired tumor corresponding normal tissues were determined RNA-Sequencing. Subsequently, matched 127 patients assayed further validation. Univariate...
While timely assessment of long-term survival for patients with breast cancer is essential evaluation on early detection and screening programs, those data are extremely scant in China. We aimed to derive most up-to-date estimates predict future using the registry from Taizhou city, Eastern China.Patients diagnosed during 2004-2018 four registries high-quality Taizhou, China were included. Period analysis was used calculate 5-year relative (RS) overall population according stratification...
Abstract Background Mental health of university volunteers is essential for the successful holding meetings and sports games. The impact personality traits on mental symptoms not well studied. study objective to assess as predictors in China. Method We carried out a cross-sectional study. sample consisted from sixteen main universities city Hangzhou. OQ-45 scale was used evaluate PHI measurement traits. Multiple linear regression analysis relationships between factors symptoms. Results...
In the past decade, prevalence of overweight and obesity in Chinese has increased markedly, especially regions economy developing quickly. And ageing also been an increasing social problem. To obtain current estimates among middle old-aged (45 years or older) developed region, a census study was carried out. Overweight defined as BMI 24 higher 28 higher, respectively. A regional representative sample (3740 males, 5174 females) included by multi-stage cluster sampling method from Zhejiang...