A5102927848- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Algal biology and biofuel production
- Lipid metabolism and biosynthesis
- Microbial Metabolites in Food Biotechnology
- Microbial Metabolic Engineering and Bioproduction
- Photosynthetic Processes and Mechanisms
- Catalysis and Oxidation Reactions
- Folate and B Vitamins Research
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Computational Drug Discovery Methods
- Congenital Anomalies and Fetal Surgery
- Urological Disorders and Treatments
- Plant-Microbe Interactions and Immunity
- Antioxidant Activity and Oxidative Stress
- Advanced Image Processing Techniques
- Machine Learning in Materials Science
- Gestational Diabetes Research and Management
- Breast Lesions and Carcinomas
- Carcinogens and Genotoxicity Assessment
- Metabolomics and Mass Spectrometry Studies
- Craniofacial Disorders and Treatments
- Advanced Combustion Engine Technologies
- Pregnancy and preeclampsia studies
Shandong Academy of Agricultural Sciences
2014-2024
Chinese Academy of Sciences
2019-2024
Wuhan Botanical Garden
2024
Zhongshan Hospital
2021-2023
Fudan University
2021-2023
Wuhan Institute of Physics and Mathematics
2019-2023
University of Chinese Academy of Sciences
2019-2023
Anhui Medical University
2020-2022
Dalian Medical University
2017-2022
National Health and Family Planning Commission
2019-2022
Objective Previous study have shown that lipid accumulation product (LAP), visceral adiposity index (VAI), triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C) and triglycerides/glucose (TyG index) could be simple clinical indicators of insulin resistance (IR) based on anthropometric and/or biochemical parameters. However, the rational preferred surrogate marker IR in different population has yet to validated. The aim this was evaluating practicability LAP, VAI, TG/HDL-C, TyG...
Hydrogen abstraction reactions between hydrocarbons and hydroxyl radicals are important propagation steps in radical chain reactions, playing a crucial role atmospheric combustion chemistry. This study focuses on predicting the rate constants of prototype reaction class hydrogen abstractions, i.e., primary allylic from alkenes by OH radical, via utilizing machine learning (ML) methods. Specifically, three distinct models, namely, feedforward neural network (FNN), support vector regression...
Spirulina is widely known as the "Super Nutritious Food of Future" due to its exceptional nutritional properties. In this article, we investigated effects fermentation using a combination Lactobacillus acidophilus KDB-03 and Kluyveromyces marxianus GDMCC 2.119 on Spirulina. Fermentation significantly increased total flavonoid phenol levels in Spirulina, enhanced 2,2-diphenyl-1-picrylhydrazyl free radical scavenging capacity ferric-reducing antioxidant power. Untargeted ultra-performance...
Polyunsaturated fatty acids (PUFAs), which contain two or more double bonds in their backbone, are the focus of intensive global research, because nutritional value, medicinal applications, and potential use as biofuel. However, ability to produce these economically important compounds is limited, it both expensive technically challenging separate omega-3 polyunsaturated (ω-3 PUFAs) from natural oils. Although biosynthetic pathways some plant microalgal ω-3 PUFAs have been deciphered,...
The hydrogen abstraction reactions of the hydroxyl radical with alkanes play an important role in combustion chemistry and atmospheric chemistry. However, site-specific reaction constants are difficult to obtain experimentally theoretically. Recently, machine learning has proved its ability predict chemical properties. In this work, a approach is developed temperature-dependent rate title reactions. Multilayered neural network (NN) models by training 11 reactions, several schemes designed...
To investigate the prevalence of gestational diabetes mellitus (GDM) and its determinants among pregnant women in Tongzhou district Beijing, China.This study was performed on data collected routine work prenatal health care system from 27,119 Beijing during 2013-2018. Univariate multivariate logistic regression analyses were used to assess factors associated with GDM.The overall GDM 24.24%, it showed an increasing trend over 6 years. A univariate analysis that increased age (p < .001). In...
Although arsenic (As), cadmium (Cd), lead (Pb), and nickel (Ni) have the ability to induce orofacial clefts (OFCs) in rodents, evidence is absent from human epidemiological investigations with markers of utero exposure. We investigated associations between concentrations As, Cd, Pb, Ni umbilical cord tissues risk OFCs, interactions each pair metals on OFC a case-control study. Umbilical were determined by inductively coupled plasma mass spectrometry 92 cases 200 nonmalformed controls....
Abstract Spirulina acts as a good dietary nutritional supplement. However, few research studies have been conducted on its fermentation. Three groups of probiotic combinations, lactic acid bacteria, Bacillus strains, and their mixture, were used to investigate The results showed that bacteria significantly increased the content amino acids ratio essential total in fermented Spirulina, compared with unfermented this trend was enhanced by strains' mixture. levels decreased after fermentation...
Recently, H. pluvialis has been demonstrated to have significant potential for biofuel production. To explore the correlation between total lipid content and other physiological parameters under s tress conditions, responses of high light intensity (HL), nitrogen deprivation (-N), with (HL-N) were investigated. The in control cells was 12.01% dw, whereas that exposed HL, -N, HL-N conditions 56.92, 46.71, 46.87% respectively. fatty acid profile similar all main components including palmitic...
Objective: Dietary n-3 polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), are proved to be effective in obesity reduction. Microalgal oil (MO) is an important alternative source of PUFAs that effectively alleviates obesity. The aim the present study was explore anti-obesity effects microalgal from Schizochytrium sp. (SMO) compare 2 SMOs (SMO1 SMO2) with different levels purity on high fat diet (HFD)-induced male C57BL/6J mice.Methods: Mice...
Astragalus Polysaccharide (APS) is the main component of membranaceus, an anti-diabetic herb being used for thousands years in Chinese Traditional Medicine (TCM). In this study, we aimed to evaluate impact APS on hepatic insulin signaling, autophagy and ER stress response high-fat-diet (HFD)-induced resistance (IR) mice. was intra gastrically administrated metformin as a control medicine. Apart from monitoring changes important parameters IR progression, gene protein expression key factors...
Abstract Background Prenatal exposure to heavy metals is implicated in the etiology of birth defects. We investigated whether concentrations cadmium (Cd) and lead (Pb) umbilical cord tissue are associated with risk for neural tube defects (NTDs) selected genetic variants fetus modify their associations. Methods This study included 166 cases NTD fetuses/newborns newborns without congenital malformations. Umbilical was collected at or elective pregnancy termination. Cd Pb were assessed by...
Precursor regulation has been an effective strategy to improve carotenoid production and the availability of novel precursor synthases facilitates engineering improvements. In this work, putative geranylgeranyl pyrophosphate synthase encoding gene (AlGGPPS) isopentenyl isomerase (AlIDI) from Aurantiochytrium limacinum MYA-1381 were isolated. We applied excavated AlGGPPS AlIDI de novo β-carotene biosynthetic pathway in Escherichia coli for functional identification application. Results showed...
Oil from Schizochytrium sp. alleviates obesity efficiently by modulating gut microbiota in high-fat diet-fed mice.