A5037696381- Nutritional Studies and Diet
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Phytoestrogen effects and research
- Pesticide and Herbicide Environmental Studies
- Microbial bioremediation and biosurfactants
- Nanoparticle-Based Drug Delivery
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Environmental Chemistry and Analysis
- Hypothalamic control of reproductive hormones
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Analytical Chemistry and Chromatography
- Consumer Attitudes and Food Labeling
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Bacterial Genetics and Biotechnology
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Health and Risk Factors
- Bioinformatics and Genomic Networks
- Bariatric Surgery and Outcomes
- Synthesis and Properties of Aromatic Compounds
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
China National Center for Food Safety Risk Assessment
2022-2025
Sichuan University
2016-2025
West China Medical Center of Sichuan University
2022-2025
Union Hospital
2025
Huazhong University of Science and Technology
2025
Nanjing University of Information Science and Technology
2023
China Meteorological Administration
2023
Chengdu University
2019-2020
West China Hospital of Sichuan University
2013
Auburn University
2009-2012
Pubertal timing is highly variable and associated with long-term health outcomes. Phenotypes pubertal include age at menarche, voice break, first facial hair growth spurt, seems to have a shared genetic architecture between the sexes. However, puberty phenotypes primarily been assessed separately, failing account for genetics, which limits reliability of purported implications. Here, we model common using multivariate GWAS, an effective population 514,750 European participants. We find 266...
Emerging evidence suggests that bioactive peptides from various foods have therapeutic potentials in improving cognitive function Alzheimer's disease (AD) and mild impairment (MCI). We aimed to explore the characteristics of these their mechanisms on AD/MCI using a network pharmacology approach. compiled dataset cognition-enhancing literatures identified shared targets between Swiss Target Predication, PharmMapper, OMIM, GeneCards, TTD, Drugbank databases. then performed functional...
Malignant melanoma is a devastating skin cancer due to its severe drug resistance and prompt metastasis. Piperlongumine an anti-inflammation tumor-suppressing natural product with defined structure. While numerous studies revealed exceptional inhibitory effects of piperlongumine on several carcinomas, few investigations were performed melanoma. Therefore, the present study investigated anti-tumor human cells in vitro, explored mechanisms action. Results from cytotoxicity proliferation...
Abstract Background Comorbidity exists between amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), but the role of genetic factors is unclear. Objective We aim to investigate correlation, causal relationship, comorbid genes ALS PD. Methods Leveraging largest genome‐wide association study data (ALS: 27,205 cases, 110,881 controls; PDG: 33,674 449,056 controls), we used linkage disequilibrium score regression Mendelian randomization analysis for correlation inference. performed...
Abstract Background Ambient air pollutants have been suggested to affect pubertal development. Nevertheless, current studies indicate inconsistent effects of these pollutants, causing precocious or delayed puberty onset. This study aimed explore the associations between long-term exposure particulate matter with aerodynamic diameters ≤ 2.5 μm (PM ) along its components and menarche timing among Chinese girls. Method Self-reported age at was collected 855 girls from China Health Nutrition...
Scope The current evidence between dietary flavonoids consumption and multiple health outcomes is inadequate inconclusive. To summarize evaluate the for outcomes, an umbrella review of meta‐analyses systematic reviews conducted. Methods results PubMed, Ovid‐EMBASE, Cochrane Database Systematic Reviews are searched up to January 2024. study includes a total 32 articles containing 24 unique in this review. Meta‐analyses recalculated by using random effects model. Separate analyses performed...
Heteroatoms were introduced as a novel modification strategy for fine-tuning the diradical character of molecular systems. Both and singlet-triplet energy gaps diketopyrrolopyrrole based phenoxyl diradicaloids decreased size substituted heteroatoms (from O, S to Se atom) increased.
Abstract Dysfunction of the hypothalamus is associated with endocrine imbalances, growth abnormalities, and reproductive disorders. However, there a lack targeted treatment strategies focused on hypothalamus. In this study, we constructed multifunctional nanocarrier system (S@ANP) to directly target hypothalamic neurokinin receptor 3 (NK3R) via an intranasal delivery strategy. This could overcome primary obstacles in drug for hypothalamus‐related diseases. Under guidance modified (Trp7,...
Background/aims Isoalantolactone (IATL) is one of multiple isomeric sesquiterpene lactones and isolated from inula helenium. IATL has functions such as antibacterial, antihelminthic antiproliferative activities. also inhibits pancreatic cancer proliferation induces apoptosis by increasing ROS production. However, the detailed mechanism IATL-mediated remains largely unknown. Methods In current study, carcinoma cell lines (PANC-1, AsPC-1, BxPC-3) a mouse xenograft model were used to determine...
Abstract How genome-wide associated loci confer risk for Parkinson’s disease is unclear. We aim to reveal causal genes through effects on brain proteins provide new pathogenesis insights disease. Proteome-wide and transcriptome-wide associations were determined by functional summary-based imputation leveraging data from association summary (56 306 Europeans, 1.4 million controls), proteomes (528 cases 2 separate sets), transcriptome (452 cases), followed Mendelian randomization, Bayesian...
Abstract Silicosis is a long‐established public health issue in developing countries due to increasingly serious air pollution and poorly implemented occupational safety regulation. Inhalation of silica triggers cytotoxicity, oxidative stress, pulmonary inflammation eventually silicosis. Current understanding the pathogenesis mechanism silicosis limited, no effective cure clinically available once developed. A number studies were conducted investigate silica‐induced alternate gene...
Despite the great achievements of nanomedicines made in cancer chemotherapy, precise tumor targeting and deep penetration are still major challenges. Many can only passively accumulate near leaky site vessels through enhanced permeability retention (EPR) effect cannot reach region tumor. To improve targeting, efficiency, an iRGD-mediated enzyme-induced gold nanoparticles system (iRGD/AuNPs-A&C) was developed by simply coadministering a tumor-homing peptide iRGD (CRGDKGPDC) with legumain...
Substrate-induced conformational changes present in alkanesulfonate monooxygenase (SsuD) are crucial to catalysis and lead distinct interactions between a dynamic loop region the active site. Accelerated molecular dynamics (aMD) simulations have been carried out examine this potential correlation by studying wild-type SsuD variant enzymes bound with different combinations of reduced flavin (FMNH2), C4a-peroxyflavin intermediate (FMNOO–), octanesulfonate (OCS). Three mobile conformations were...