A5036790547- Heart Failure Treatment and Management
- Ion Channels and Receptors
- Pesticide Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Neurobiology and Insect Physiology Research
- Toxic Organic Pollutants Impact
- Biochemical Analysis and Sensing Techniques
- Phosphodiesterase function and regulation
- Phytochemicals and Antioxidant Activities
- Ion channel regulation and function
- Insect and Pesticide Research
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Renin-Angiotensin System Studies
- Electrolyte and hormonal disorders
- Protein Kinase Regulation and GTPase Signaling
- Effects and risks of endocrine disrupting chemicals
- Receptor Mechanisms and Signaling
- Plant-based Medicinal Research
- Rabbits: Nutrition, Reproduction, Health
- Agricultural safety and regulations
- Animal Ecology and Behavior Studies
- Animal testing and alternatives
- Chemistry and Chemical Engineering
- Muscle Physiology and Disorders
Uniformed Services University of the Health Sciences
2011-2024
National Institute of Allergy and Infectious Diseases
2008-2015
National Institutes of Health
2003-2013
National Institute of Diabetes and Digestive and Kidney Diseases
2003-2011
University of Cambridge
2002-2004
Lund University
2002
University of Richmond
1968-1971
Bionetics (United States)
1971
National Cancer Institute
1970
Virginia Commonwealth University Medical Center
1968
In model organisms, resistance to inhibitors of cholinesterase 8 (Ric-8), a G protein alpha (G alpha) subunit guanine nucleotide exchange factor (GEF), functions orient mitotic spindles during asymmetric cell divisions; however, whether Ric-8A has any role in mammalian division is unknown. We show here that and alpha(i) function the metaphase spindle adherent cells. During mitosis, localized at cortex, poles, centromeres, central spindle, midbody. Pertussis toxin proved be useful tool these...
There is a body of evidence suggesting that Ca2+ handling proteins assemble into signaling complexes required for fine regulation signals, events regulate variety critical cellular processes. Canonical transient receptor potential (TRPC) and Orai have both been proposed to form Ca2+-permeable channels mediating entry upon agonist stimulation. A number studies demonstrated inositol 1,4,5-trisphosphate receptors (IP3Rs) interact with plasma membrane TRPC channels; however, at present there no...
Mammalian cells accumulate Ca2+ into agonist-sensitive acidic organelles, vesicles that possess a vacuolar proton-ATPase. Acidic stores include secretory granules and lysosome-related organelles. Current evidence clearly indicates participate in cell signaling function, including the activation of store-operated entry human platelets upon depletion stores, although mechanism underlying controlled by remains unclear. STIM1 has been presented as endoplasmic reticulum sensor, but its role...
Sensitive, specific, and noninvasive detection of angiogenesis would be helpful in discovering new strategies for the treatment cardiovascular diseases. Recently, we reported <sup>64</sup>Cu-labeled C-type atrial natriuretic factor (CANF) fragment detecting upregulation peptide clearance receptor (NPR-C) with PET on atherosclerosis-like lesions an animal model. However, it is unknown whether NPR-C present overexpressed during angiogenesis. The goal this study was to develop a novel...
Cardiovascular disease is the leading cause of death worldwide. PET has potential to provide information on biology and metabolism atherosclerotic plaques. Natriuretic peptides (NPs) have potent antiproliferative antimigratory effects vascular smooth-muscle cells (VSMCs) and, in atherosclerosis, participate remodeling, which expression NP clearance receptors (NPR-Cs) upregulated both endothelium VSMCs. <b>Methods:</b> We investigated a C-type atrial natriuretic factor (C-ANF) image...
The store-operated Ca2+ entry-associated regulatory factor (SARAF) has recently been identified as a STIM1 protein that facilitates slow Ca2+-dependent inactivation of entry (SOCE). Both the channels and store-independent arachidonate-regulated (ARC) are regulated by STIM1. In present study, we show that, in addition to its location endoplasmic reticulum, SARAF is constitutively expressed plasma membrane, where it can interact with membrane (PM)-resident ARC forming subunits neuroblastoma...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetabolism of Chlorinated Hydrocarbon InsecticidesGeoffrey Woodard, Bernard Davidow, and Arnold LehmanCite this: Ind. Eng. Chem. 1948, 40, 4, 711–712Publication Date (Print):April 1, 1948Publication History Published online1 May 2002Published inissue 1 April 1948https://pubs.acs.org/doi/10.1021/ie50460a032https://doi.org/10.1021/ie50460a032research-articleACS PublicationsRequest reuse permissionsArticle Views18Altmetric-Citations13LEARN ABOUT THESE...
RETURN TO ISSUEPREVNewsNEXTSummary of Toxicological Studies the Insecticide DDT2,2-Bis (p-chlorophenyl) 1,1,1-trichloroethaneJOHN H. DRAIZE, GEOFFREY WOODARD, O. GARTH FITZHUGH, ARTHUR A. NELSON, R. BLACKWELL SMITH, JR., and HERBERT CALVERY2View Author Information Division Pharmacology, Food Drug Administration, Federal Security Agency, Washington, D. C.Cite this: Chem. Eng. News 1944, 22, 17, 1503–1504Publication Date (Print):September 10, 1944Publication History Published online4 November...