A5100459799- COVID-19 Clinical Research Studies
- Acute Ischemic Stroke Management
- Computational Drug Discovery Methods
- Cerebrovascular and Carotid Artery Diseases
- Molecular Sensors and Ion Detection
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- COVID-19 Impact on Reproduction
- Nitric Oxide and Endothelin Effects
- Pharmacogenetics and Drug Metabolism
- Medicinal Plants and Bioactive Compounds
- Cholinesterase and Neurodegenerative Diseases
- Reproductive Physiology in Livestock
- Genetic and rare skin diseases.
- Medical Imaging and Analysis
- Echinoderm biology and ecology
- Magnolia and Illicium research
- Lipid metabolism and disorders
- Genetic and phenotypic traits in livestock
- Histiocytic Disorders and Treatments
- Alkaloids: synthesis and pharmacology
- Supramolecular Chemistry and Complexes
- Apelin-related biomedical research
University of Oxford
2024-2025
East China Normal University
2021-2025
Huaian First People’s Hospital
2024
Nanjing Medical University
2024
Chengdu Third People's Hospital
2023
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2021
Wuhan University
2010-2020
Renmin Hospital of Wuhan University
2010-2020
National Center for Toxicological Research
2019-2020
United States Food and Drug Administration
2019-2020
Abstract Background A recently developing pneumonia caused by SARS-CoV-2 was originated in Wuhan, China, and has quickly spread across the world. We reported clinical characteristics of 82 death cases with COVID-19 a single center. Methods Clinical data on laboratory-confirmed as infection were obtained from Wuhan local hospital’s electronic medical records according to previously designed standardized collection forms. Results All patients residents great proportion them diagnosed severe...
Fucoidans, fucose-enriched sulfated polysaccharides isolated from brown algae and marine invertebrates, have been shown to exert anticancer activity in several types of human cancer, including leukemia breast cancer lung adenocarcinoma cells. In the present study, fucoidan extracted seaweed Undaria pinnatifida was investigated hepatocellular carcinoma SMMC-7721 cells, underlying mechanisms action were investigated. cells exposed displayed growth inhibition typical features apoptotic such as...
Adverse Drug Reactions (ADRs) are of great public health concern. FDA-approved drug labeling summarizes ADRs a product mainly in three sections, i.e., Boxed Warning (BW), Warnings and Precautions (WP), (AR), where the severity intended to decrease order BW > WP AR. Several reported studies have extracted from documents, but most, if not all, did discriminate by different sections. Such practice could overstate or underestimate impact certain health. In this study, we applied Medical...
Oxidative stress and neuroinflammation are two major causes leading to early brain injury after subarachnoid hemorrhage (SAH). Nuclear factor E2-related 2 (Nrf2) is a critical transcription that contributes antioxidant responses. Additionally, Nrf2 could inhibit transforming growth beta-activated kinase 1 (TAK1), which plays vital role in microglial activation-mediated neuroinflammation. Neferine (NE) exhibits considerable protective effects diverse disease models. However, the detailed...
Pharmacogenomics (PGx), studying the relationship between drug response and genetic makeup of an individual, is accelerating advances in precision medicine. The FDA includes PGx information labeling approved drugs to better inform on their safety effectiveness. We herein present a summary found 261 prescription documents by querying publicly available FDALabel database. A total 362 drug-biomarker pairs (DBPs) were identified. profiled DBPs using frequency biomarkers therapeutic classes. Four...
Developing a novel tool capable of real-time monitoring and accurate quantification NO is critical to understanding its role in physiological pathological processes. Herein, two-photon ratiometric fluorescent probe (NOP) was developed for imaging based on fluorescence resonance energy transfer-photoinduced electron transfer (FRET-PET). In this probe, coumarin (CM) naphthalimide with o-phenylenediamine (NPM) were rationally designed as donor acceptor, respectively, enable response NO. The...
Abstract Accurately visualizing epinephrine (EP) activity is essential for understanding its physiological functions and pathological processes in brain. However, to the best of our knowledge, reliable, rapid, specifical measurement EP dynamics at cellular vivo level hasn’t been previously reported. Herein, we report probe imaging biosensing neurons living brain freely behaving animals, based on creating a series supramolecular fluorescent chemodosimeters through host-guest interaction. The...
Abstract BACKGROUND: Immune aging, characterized by altered phenotypes and functions of natural acquired immunity, constitutes a significant threat indicator factor for atherosclerosis due to its association with chronic inflammation. However, the comprehensive understanding underlying biological changes driving immune aging in atherosclerosis, particularly relation late-stage plaque formation, remains incomplete. The objective this research is unravel influence aging-related genes on...
Open AccessCCS ChemistryRESEARCH ARTICLE6 Jun 2022A Highly Stable Two-Photon Ratiometric Fluorescence Probe for Real-Time Biosensing and Imaging of Nitric Oxide in Brain Tissues Larval Zebrafish Zhiwen Gong, Zhichao Liu, Zhonghui Zhang, Yuxiao Mei Yang Tian Gong Shanghai Key Laboratory Green Chemistry Chemical Processes, School Molecular Engineering, East China Normal University, 200241 Google Scholar More articles by this author , Liu Zhang *Corresponding author: E-mail Address: [email...
A high-density Raman photometry based on a dual-recognition strategy is created for accurately quantifying acetylcholinesterase (AchE) activity in 24 brain regions of free-moving animals with network. series 5-ethynyl-1,2,3,3-tetramethyl-based molecules different conjugated structures and substitute groups are designed synthesized specific recognition AchE by spectroscopy. After systematically evaluating the ability toward AchE,...
Depression is a disease that seriously threatens the quality of human life. To explore effect gentiopicroside on depression, this study investigated therapeutic corticosterone-induced depressionin vivo and in vitro by using metabolomic methods. A total 36 rats were randomly assigned to three groups: normal group, model group (depression), treatment (depression + gentiopicroside). Corticosterone was administrated induce depression-like rats. Morris water maze test used validated behavior...
With the widespread outbreak of novel coronavirus diseases 2019(COVID-19), more and death cases were reported, however, limited data are available for patients who died. We aimed to explore clinical characteristics deaths with COVID-19 pneumonia.
Objective To evaluate the predictive value of fasting blood glucose (FBG) on unfavourable outcomes and mortality in diabetes mellitus (DM) patients after acute ischaemic stroke (AIS). Study design A hospital-based observational cohort study was conducted. Clinical data, including sex, age, body mass index, vascular risk factors systolic/diastolic pressure, were routinely collected. National Institutes Health Stroke Scale score used to assess severity admission. FBG determined first day for...
Abstract Intracranial artery calcification (IAC) is an important risk factor for cerebral infarction and a key biomarker intracranial stenosis. Small dense low-density lipoprotein cholesterol (sd-LDL-c) was independently associated with increased cardiovascular events coronary calcification. Our study assessed whether sd-LDL-c independent IAC in acute ischemic stroke (AIS) patients. This cross-sectional involved total of 754 patients AIS (mean age: 65 ± 13.2 years). All the had received...
Abstract Intracranial artery calcification (IAC) is an important risk factor for cerebral infarction and a key biomarker intracranial stenosis. Gamma-glutamyl transferase (GGT) has been independently associated with increased cardiovascular events coronary calcification. Our study assessed whether GGT independent IAC in acute ischemic stroke (AIS) patients. This cross-sectional involved total of 754 patients AIS (mean age: 65 ± 13.2 years). All the had received brain computed tomography...
Background: With the widespread outbreak of (novel coronavirus disease 2019 ) COVID-19, more and death cases were reported, however, limited data are available for patients who died. We aimed to explore epidemiological clinical characteristics deaths with COVID-19 pneumonia. Methods: This is a single-center retrospective study. abstracted analyzed epidemiological, demographic, clinical, laboratory from pneumonia in East hospital Wuhan university Renmin hospital,between January 26, 2020,...
Interferon-tau (IFNT) is the main signal for maternal recognition of pregnancy in ruminants.IFNT acts on endometrium, corpus luteum, and liver through paracrine endocrine style, which involved inhibiting development luteolytic mechanism suppressing immune rejection semi-allogeneic fetus.Bone marrow (BM) a key component lymphatic system, supports body's system producing lymphocytes.At present study, BM was obtained from days 13, 16 25 pregnant ewes, day non-pregnant ewes to study expression...
Abstract Background Autism spectrum disorders (ASD) is a neurodevelopmental disorder with high incidence rate and difficult diagnosis. The purpose of this study was to explore whether salivary cortisol, dehydroepiandrosterone (DHEA) pregnenolone can be used as biomarkers ASD children. Methods saliva samples 55 boys were collected the experimental group, 24 neurotypical control group. Child Behavior Checklist (CBCL), (ABC), Social Responsiveness Scale (SRS), Repetitive (RBS) assess severity...
Abstract Background We aimed to identify clinical features of coronavirus disease 2019 (COVID-19) in children and evaluate the role procalcitonin early differential diagnosis. Methods A retrospective analysis was performed on all suspected pediatric cases. Results 39 (50.6%) 77 cases were comfirmed, 4 (5.2%) them had viral coinfection. Compared with non-COVID-19 group (n=33), COVID-19 confirmed (n=39) fewer fever(OR[95% CI]0.467[0.314-0.694]; P=.000) symptoms acute respiratory infection...
Previous studies have reported controversial relationships between circulating vascular endothelial growth factors (VEGF) and ischemic stroke (IS). This study aims to demonstrate the causal effect VEGF IS using Mendelian randomization (MR). Summary statistics data from two large-scale genome-wide association (GWAS) for 16,112 patients with measured levels 40,585 were downloaded public databases included in this study. A published calculator was adopted MR power calculation. The primary...
This study aims to ascertain the predictive value of platelet and inflammation markers in severe cases COVID-19.
Abstract Background: With the widespread outbreak of novel coronavirus diseases 2019(COVID-19), more and death cases were reported, however, limited data are available for patients who died. We aimed to explore clinial characteristics deaths with COVID-19 pneumonia Methods: abstracted analyzed epidemiological, demographic, clinical, laboratory from 83 in East hospital Wuhan university Renmin hospital,between January 26, 2020, February 28, 2020. Results: Of deaths, none was medical staff. The...