A5026847607- Nanoparticles: synthesis and applications
- Pharmaceutical studies and practices
- Pharmacovigilance and Adverse Drug Reactions
- Biomedical Ethics and Regulation
- Electrochemical Analysis and Applications
- Heavy Metal Exposure and Toxicity
- Computational Drug Discovery Methods
- Microplastics and Plastic Pollution
- Nanoparticle-Based Drug Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Biosensors and Analytical Detection
- Carbon Nanotubes in Composites
- Healthcare and Environmental Waste Management
- Flavonoids in Medical Research
- Phytochemistry and Biological Activities
- Mercury impact and mitigation studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Receptor Mechanisms and Signaling
- Graphene and Nanomaterials Applications
- Health Systems, Economic Evaluations, Quality of Life
- Air Quality and Health Impacts
- Heavy metals in environment
- Pharmacogenetics and Drug Metabolism
- Medicinal Plants and Bioactive Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
National Center for Toxicological Research
2015-2020
United States Food and Drug Administration
2015-2020
Arkansas State University
2008-2014
Arkansas Biosciences Institute
2008-2014
Abstract Innovative research and diagnostic techniques for biological testing have advanced during recent years because of the development semiconductor nanocrystals. Although these commercially available, fluorescent nanocrystals a protective organic coating, inner core contains cadmium selenium. Because metals potential detrimental environmental effects, concerns been raised over our lack understanding about fate products. U.S. Environmental Protection Agency test protocol fluorescence...
The physicochemical characteristics of silver nanoparticles (AgNPs) may greatly alter their toxicological potential. To explore the effects size and coating on cytotoxicity genotoxicity AgNPs, six different types having three sizes two coatings, were investigated using Ames test, mouse lymphoma assay (MLA) in vitro micronucleus assay. genotoxicities acetate nitrate evaluated to compare nanosilver that ionic silver. test produced inconclusive results for all materials due high toxicity...
Adverse Drug Reactions (ADRs) are of great public health concern. FDA-approved drug labeling summarizes ADRs a product mainly in three sections, i.e., Boxed Warning (BW), Warnings and Precautions (WP), (AR), where the severity intended to decrease order BW > WP AR. Several reported studies have extracted from documents, but most, if not all, did discriminate by different sections. Such practice could overstate or underestimate impact certain health. In this study, we applied Medical...
Pharmacogenomics (PGx), studying the relationship between drug response and genetic makeup of an individual, is accelerating advances in precision medicine. The FDA includes PGx information labeling approved drugs to better inform on their safety effectiveness. We herein present a summary found 261 prescription documents by querying publicly available FDALabel database. A total 362 drug-biomarker pairs (DBPs) were identified. profiled DBPs using frequency biomarkers therapeutic classes. Four...
As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about long term effects of these materials. This study was designed to evaluate whether gold (10 nm), silver (50 or silica nm) administered intravenously mice for up 8 weeks at doses known be sub-toxic (non-toxic single acute repeat dosing levels) clinically relevant could produce significant bioaccumulation liver spleen macrophages. Repeated with...
ABSTRACT Because of their small size, robust structure and unique characteristics, carbon nanotubes (CNTs) are increasingly being used in a variety biomedical applications, materials products. As use increases, so does the probability unintended release human exposure. Therefore, it is important to establish potential biodistribution biopersistence better understand effects exposure humans. This study examines distribution CNTs CD‐1 mice after by inhalation single‐walled (SWCNTs)...
The goal of this study was to determine whether bacterial clearance in a rodent model would be impaired upon exposure gold, silver or silica nanoparticles (NPs).Mice received weekly injections NPs followed by challenge Listeria monocytogenes (LM). On days 3 and 10 after LM injections, the animals were sacrificed their tissues collected for elemental analysis, electron microscopy count determination.The untreated NP-treated cleared at same rate suggesting that bioaccumulation did not increase...