A5007325677- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Organ Donation and Transplantation
- Hepatitis C virus research
- Transplantation: Methods and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bariatric Surgery and Outcomes
- Abdominal vascular conditions and treatments
- Viral-associated cancers and disorders
- Renal and Vascular Pathologies
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Parathyroid Disorders and Treatments
- Drug-Induced Adverse Reactions
- Plant Disease Resistance and Genetics
- Abdominal Surgery and Complications
- Liver physiology and pathology
- Vascular anomalies and interventions
- Hemoglobinopathies and Related Disorders
- Diet and metabolism studies
- Liver Diseases and Immunity
- Thyroid Cancer Diagnosis and Treatment
Rutgers New Jersey Medical School
2019-2024
Rutgers, The State University of New Jersey
2019-2024
University Hospital, Newark
2019-2024
Texas Tech University
2021
Eastern Hepatobiliary Surgery Hospital
2020
Second Military Medical University
2020
University of Cincinnati
2014-2018
University of Cincinnati Medical Center
2014-2017
Sabin Vaccine Institute
2015-2016
Orthopaedic Research Foundation
2015
Breakthroughs in hepatitis C virus (HCV) treatment and rising rates of intravenous drug use have led to an increase the number organ donors who are HCV antibody-positive but serum nucleic acid test (NAT)-negative. The risk transmission from liver grafts these recipients is unknown. To estimate incidence transmission, we prospectively followed 26 consecutive antibody-negative (n = 25) or NAT-negative 1) transplant received a graft were between March 2016 2017. was considered occurred if...
Background and Aims: In liver transplantation, cold preservation induces ischemia, resulting in significant reperfusion injury. Hypothermic oxygenated machine perfusion (HMP-O 2 ) has shown benefits compared to static storage (SCS) by limiting ischemia-reperfusion This study reports outcomes using a novel portable HMP-O device the first US randomized control trial. Approach Results: The PILOT trial (NCT03484455) was multicenter, randomized, open-label, noninferiority trial, with participants...
Antibody-mediated rejection (AMR) is an uncommon, but challenging type of after solid organ transplantation. We review three cases AMR in ABO-compatible liver transplant recipients. These were characterized by severe acute resistant to steroids and antithymocyte globulin, histologic evidence plasma cell infiltrates, C4d positivity high serum anti-HLA donor-specific antibodies. All patients treated with bortezomib, a proteasome inhibitor effective depleting cells. After treatment, all had...
Morbid obesity is a barrier to renal transplantation and inadequately addressed by medical therapy. We present results of prospective evaluation laparoscopic sleeve gastrectomy (LSG) for patients failing achieve significant weight loss with Over 25-month period, 52 obese transplant candidates meeting NIH guidelines metabolic surgery underwent LSG. Mean age was 50.0 ± 10.0 years an average preoperative BMI 43.0 5.4 kg/m(2) (range 35.8-67.7 kg/m(2)). Follow-up after LSG 220 152 days 26-733...
The use of donation after circulatory death (DCD) liver allografts has been constrained by limitations in the duration donor warm ischemia time (DWIT), agonal (DAT), and cold (CIT). purpose this study is to assess impact longer DWIT, DAT, CIT on graft survival other outcomes DCD transplants. Scientific Registry Transplant Recipients was queried for adult transplants from donors between 2009 2015. Donor, recipient, center variables were included analysis. During period, 2107 patients...
Abstract Background & Aims We sought to analyse the effect of pretransplant diabetes on post‐operative outcomes and resource utilization following liver transplantation. Methods A retrospective cohort study was designed using a linkage between University HealthSystem Consortium Scientific Registry Transplant Recipients databases. identified 12 442 patients who underwent transplantation at 63 centres from 2007–2011 separated cohorts with ( n = 2971; 24%) without 9471; 76%) time...
The rate and causes of hospital readmissions after liver transplantation (LT) remain largely unknown in the United States. Adult patients (n = 11,937; 43.1% all LT cases) undergoing from 2007 to 2011 were examined with a linkage University HealthSystem Consortium Scientific Registry Transplant Recipients databases determine incidence risk factors for 30-day utilization metrics 90 days LT. overall readmission was 37.9%, half admitted within 7 discharge. Readmitted had worse graft patient...
Objective: To define benchmark cutoffs for redo liver transplantation (redo-LT). Background: In the era of organ shortage, redo-LT is frequently discussed in terms expected poor outcome and wasteful resources. However, there a lack data to reliably evaluate outcomes after redo-LT. Methods: We collected on between January 2010 December 2018 from 22 high-volume transplant centers. Benchmark cases were defined as recipients with model end stage disease (MELD) score ≤25, absence portal vein...
Morbid obesity is a barrier to renal transplantation and inadequately addressed by medical therapy. We present results of prospective evaluation laparoscopic sleeve gastrectomy (LSG) for patients failing achieve significant weight loss with Over 25-month period, 52 obese transplant candidates meeting NIH guidelines metabolic surgery underwent LSG. Mean age was 50.0 ± 10.0 years an average preoperative BMI 43.0 5.4 kg/m2 (range 35.8–67.7 kg/m2). Follow-up after LSG 220 152 days 26–733 days)...
The use of liver allografts from elderly donors (≥70 years) has increased because organ shortage and life expectancy. aim this study is to evaluate the current utilization in United States, recipient selection, their posttransplant outcomes.A linkage between Scientific Registry Transplant Recipients University HealthSystem Consortium databases was performed. Between January 2007 December 2011, 12,445 transplant (LT) recipients were identified divided into 2 cohorts based on donor age: 70...
Background: Direct-acting antiviral agents are now available to treat chronic hepatitis C virus (HCV) infection in patients with end-stage renal disease (ESRD). Objective: To examine whether it is more cost-effective transplant HCV-infected or HCV-uninfected kidneys into patients. Design: Markov state-transition decision model. Data Sources: MEDLINE searches and bibliographies from relevant English-language articles. Target Population: ESRD receiving hemodialysis the United States. Time...
Abstract The results of simultaneous liver-kidney transplants in highly sensitized recipients have been controversial terms antibody-mediated rejection and kidney allograft outcomes. This case report provides a detailed sophisticated documentation histocompatibility pathologic data transplant performed recipient with multiple high-titered class I II antidonor HLA antibodies strongly positive cytotoxic crossmatch. Patient received induction steroids, rituximab, eculizumab without lymphocyte...
For more than 20 years, placement of a transjugular intrahepatic portosystemic shunt (TIPS) has been first-line treatment option for portal hypertension in patients with decompensated cirrhosis. It used the management complications such as variceal bleeding and refractory ascites.1-3 The most commonly reported TIPS include hepatic encephalopathy (10%-49%), stenosis or occlusion (13%-15% covered stents 18%-78% bare stents), sepsis (2%-10%), stent migration to vein right atrium (8%-20%).1, 4...
Reduction in donor-specific antibody (DSA) has been associated with improved renal allograft survival after antibody-mediated rejection (AMR). These observations have not separately analyzed for early and late AMR mixed acute (MAR). The purpose of this study was to evaluate long-term responses proteasome inhibitor-based therapy 4 phenotypes determine factors that predict survival.Retrospective cohort evaluating transplant recipients first episodes treated from January 2005 July 2015.A total...