A5064209696- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Biosimilars and Bioanalytical Methods
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Medication Adherence and Compliance
- Antibiotics Pharmacokinetics and Efficacy
- HIV/AIDS drug development and treatment
- Organ Donation and Transplantation
- Systemic Lupus Erythematosus Research
- Hemoglobinopathies and Related Disorders
- Neurological Complications and Syndromes
- Parvovirus B19 Infection Studies
- Acute Kidney Injury Research
- Prenatal Substance Exposure Effects
- Adolescent and Pediatric Healthcare
- Pregnancy and Medication Impact
- Erythrocyte Function and Pathophysiology
- Central Venous Catheters and Hemodialysis
- Pharmaceutical Practices and Patient Outcomes
- Advanced Biosensing Techniques and Applications
- Cytomegalovirus and herpesvirus research
- Cannabis and Cannabinoid Research
- Erythropoietin and Anemia Treatment
- Bacterial Identification and Susceptibility Testing
University of Michigan
2016-2024
The Ohio State University Wexner Medical Center
2018-2022
University of Cincinnati Medical Center
2017-2019
Cannabidiol (CBD), a major purified nonpsychoactive component of cannabis with anticonvulsant properties, was approved by the U.S. Food and Drug Administration (FDA) in June 2018 as an adjuvant treatment for refractory epilepsy (Epidiolex; GW Pharmaceuticals). CBD is metabolized cytochrome P450 (CYP)3A4 CYP2C19 growing body evidence suggesting it also potent inhibitor these pathways. We report first time significant drug-drug interaction between product tacrolimus. A participant clinical...
The purpose of this study was to determine the intrapatient (within same patient) variability tacrolimus in adherent patients. Daily trough levels were obtained at home using dried blood spot technology kidney and liver transplant recipients. Patients randomized receive 3 formulations tacrolimus, each for two 1-week periods. Adherence monitored by patient diary, pill counts, use Medication Event Monitoring System (MEMS). Variability quantified as coefficient variation (CV). Comparison CV...
Abstract Background Severe obesity has been shown to limit access renal transplantation in patients with end‐stage disease ( ESRD ). Laparoscopic sleeve gastrectomy LSG ) performed the population assist achieving waitlist and transplant eligibility. Little is known about how impacts bioequivalence of tacrolimus products immunosuppression pharmacokinetics. Methods This was a prospective, open‐label, single‐dose, crossover, two‐period pharmacokinetic PK study. The purpose this study assess...
OBJECTIVE To evaluate statin use in the U.S. before and after 2015 American Diabetes Association position statement, which expanded therapy recommendations to include all adults 40–75 years old with diabetes. RESEARCH DESIGN AND METHODS The National Health Nutrition Examination Survey (NHANES) was used obtain a representative sample. difference-in-differences technique determined impact of recommendation on proportion people diabetes for whom newly recommended. RESULTS Among diabetes, change...
Aims Dried blood volumetric absorptive microsamples (VAMS) may facilitate home‐based sampling to enhance therapeutic drug monitoring after transplantation. This study aimed clinically validate a liquid chromatography–tandem mass spectrometry assay using 2 VAMS devices with different locations (Tasso‐M20 for the upper arm and Mitra finger). Patient preferences were also evaluated. Methods Clinical validation was performed tacrolimus mycophenolic acid by comparison of paired venipuncture...
Abstract The endeavor to study desensitization in kidney transplantation has not been matched by an effort investigate strategies prevent sensitization. In this ( NCT 02437422), we investigated the safety, impact on sensitization, and pharmacokinetics of SANGUINATE SG ), a hemoglobin‐based oxygen carrier, as potential alternative packed red blood cells PRBC ) transplant candidates with end‐stage renal disease ESRD ). Ten subjects meeting inclusion/exclusion (I/E) criteria were planned...
Introduction: High tacrolimus intrapatient variability is associated with poor outcomes following transplantation. A commonly hypothesized cause of this medication non-adherence, but has not been conclusively demonstrated. Research Question: The purpose study was to evaluate the relationship between adherence and variability. Design: This a retrospective cohort kidney transplant recipients. Adherence assessed at 12-month clinic visit as composite patient self-report, pharmacist assessment,...
Purpose . Drug dose recommendations are not well defined in patients undergoing continuous renal replacement therapy (CRRT) due to limited published data. Several guidelines and pharmacokinetic equations have been proposed as tools for CRRT drug dosing. Dose derived from these methods yet be compared or prospectively evaluated. Methods A literature search of PubMed, Micromedex, Embase was conducted 40 drugs commonly used the ICU gather data acquired with acute chronic kidney disease healthy...
Reduction in donor-specific antibody (DSA) has been associated with improved renal allograft survival after antibody-mediated rejection (AMR). These observations have not separately analyzed for early and late AMR mixed acute (MAR). The purpose of this study was to evaluate long-term responses proteasome inhibitor-based therapy 4 phenotypes determine factors that predict survival.Retrospective cohort evaluating transplant recipients first episodes treated from January 2005 July 2015.A total...
Background: Volumetric absorptive microsampling may reduce the blood collection burden associated with therapeutic drug monitoring of immunosuppression to prevent organ transplant rejection. This work describes development a laboratory and analytical technique for quantifying tacrolimus mycophenolic acid (MPA) from Tasso-M20™ in human whole using bead-based impact-assisted extraction. Results: The sampled volume was accurate estimated volumes within <2% expected 20 μl. Recovery extraction...
This study investigated the effect of CYP3A5 phenotype on time in therapeutic range (TTR) tacrolimus post-transplant pediatric patients.This retrospective assessed medical records kidney and heart recipients with available genotype for dosing, troughs, clinical events (biopsy-proven acute rejection [BPAR] de novo donor-specific antibodies [dnDSA]).The primary outcome, mean TTR first 90 days post-transplant, was 9.0% (95% CI: -16.1, -1.9) lower expressers (p = 0.014) when adjusting to...
Abstract Background Currently, there is limited literature evaluating rATG induction dosing and incidence of opportunistic viral infections when using steroid‐free maintenance immunosuppression. Methods This single‐center, retrospective, study compared high (>4.5 mg/kg) versus low (<4.5 the overall early infection at 180 days in setting immunosuppression consisting tacrolimus, mycophenolate, rapid steroid withdrawal, a tiered antiviral prevention strategy based on donor‐recipient...
Background: Volumetric absorptive microsamples (VAMS) can support pharmacokinetic / pharmacodynamic studies. We present the bioanalytical method development for simultaneous quantification of ampicillin, cefepime, ceftriaxone, meropenem, piperacillin, tazobactam, and vancomycin from VAMS. Methods & results: Optimal extraction, chromatographic, mass spectrometry conditions were identified. Maximum extraction recoveries included 100 μl water rehydration methanol protein precipitation....