A5087380729- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Organ Donation and Transplantation
- Chronic Kidney Disease and Diabetes
- Complement system in diseases
- Pancreatic function and diabetes
- Neurological Complications and Syndromes
- Drug-Induced Adverse Reactions
- Ion Transport and Channel Regulation
- Pediatric Urology and Nephrology Studies
- Transplantation: Methods and Outcomes
- Biomedical Research and Pathophysiology
- Polyomavirus and related diseases
- Organ and Tissue Transplantation Research
- Renal and Vascular Pathologies
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Acute Kidney Injury Research
- Pregnancy and Medication Impact
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Dialysis and Renal Disease Management
- Adenosine and Purinergic Signaling
- Blood groups and transfusion
Mayo Clinic in Florida
2022-2025
Mayo Clinic in Arizona
2023-2025
WinnMed
2022-2024
Mayo Clinic Hospital
2022-2023
Cincinnati VA Medical Center
2017-2020
University of Cincinnati
2012-2020
University of Cincinnati Medical Center
2014-2020
Christ Hospital
2015
Houston Methodist
2015
Methodist Hospital
2015
A prospective iterative trial of proteasome inhibitor (PI)-based therapy for reducing HLA antibody (Ab) levels was conducted in five phases differing bortezomib dosing density and plasmapheresis timing. Phases included 1 or 2 cycles (1.3 mg/m(2) × 6-8 doses), one rituximab dose plasmapheresis. Abs were measured by solid phase flow cytometry (FCM) assays. Immunodominant Ab (iAb) defined as highest level. Forty-four patients received 52 desensitization courses (7 enrolled multiple phases):...
Although several strategies for treating early antibody-mediated rejection (AMR) in kidney transplants have been investigated, evidence on treatment of late AMR manifesting after 6 months is sparse. In this single-center series, we present data 23 consecutive patients treated AMR.Late was diagnosed using Banff 2007 criteria along with presence donor-specific antibodies (DSA) and acute rise serum creatinine (SCr). Response to therapy assessed by improvement SCr, histologic improvement,...
Chronic kidney disease progression can be predicted based on the degree of tubular atrophy, which is result proximal tubule apoptosis. The Na+/H+ exchanger NHE1 regulates cell survival through interaction with phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], but pathophysiologic triggers for inactivation are unknown. Because glomerular injury permits luminal exposure and reabsorption fatty acid/albumin complexes, we hypothesized that accumulation amphipathic, long-chain acyl-CoA (LC-CoA)...
Tubular atrophy predicts chronic kidney disease progression, and is caused by proximal tubular epithelial cellcaused cell (PTC) apoptosis. The normally quiescent Na(+)/H(+) exchanger-1 (NHE1) defends against PTC apoptosis, regulated PI(4,5)P(2) binding. Because of the vast array plasma membrane lipids, we hypothesized that NHE1-mediated survival dynamically multiple anionic inner leaflet phospholipids. In overlay surface plasmon resonance assays, NHE1 C terminus bound phospholipids with low...
In Brief Background Classification of acute rejection (AR) based on etiology and timing may provide a means for enhancing therapeutic results allograft survival. This study evaluated graft patient survival after the first AR episodes among kidney transplant recipients with an early or late antibody-mediated (AMR), cellular (ACR) mixed (MAR). Methods A prospective institutional review board–approved database was queried to identify biopsy-proven occurring from January 2005 October 2012. The...
Abstract The endeavor to study desensitization in kidney transplantation has not been matched by an effort investigate strategies prevent sensitization. In this ( NCT 02437422), we investigated the safety, impact on sensitization, and pharmacokinetics of SANGUINATE SG ), a hemoglobin‐based oxygen carrier, as potential alternative packed red blood cells PRBC ) transplant candidates with end‐stage renal disease ESRD ). Ten subjects meeting inclusion/exclusion (I/E) criteria were planned...
JC polyomavirus (JCPyV) is a ubiquitous virus that can be latent in the brain and kidney. It etiologic agent responsible for progressive multifocal leukoencephalopathy, fatal, demyelinating disease of central nervous system, rarely causes nephropathy immunocompromised kidney transplant recipients.We present first case JCPyV simultaneous heart-kidney patient, where viral-specific situ hybridization staining tissue was utilized to confirm diagnosis. The patient diagnosed 6 years after...
Background: Contrast-induced nephropathy (CIN) in native kidneys is associated with a significant increase mortality and morbidity. Data regarding CIN renal allografts limited however. We retrospectively studied at our institution: its incidence, risk factors effect on long-term outcomes including allograft loss death. Methods: 135 transplant recipients undergoing 161 contrast-enhanced CT scans (CT) or coronary angiograms (Cath) between years 2000 2013 were identified. Contrast agents iso-...
<b><i>Background:</i></b> Apolipoprotein L1 gene (APOL1) variants predispose to nondiabetic kidney disease in African American (AA) patients. Here, we share our experience with APOL1 genotyping of AA potential living donors and offer a perspective on its utility cost-effectiveness this population. <b><i>Methods:</i></b> Since May 2017, all at center underwent early the donor evaluation process. high-risk individuals were declined, whereas those...
Reduction in donor-specific antibody (DSA) has been associated with improved renal allograft survival after antibody-mediated rejection (AMR). These observations have not separately analyzed for early and late AMR mixed acute (MAR). The purpose of this study was to evaluate long-term responses proteasome inhibitor-based therapy 4 phenotypes determine factors that predict survival.Retrospective cohort evaluating transplant recipients first episodes treated from January 2005 July 2015.A total...
In Brief Background Histology remains a cornerstone for antibody-mediated rejection (AMR) diagnosis. Little data exist supporting histology assessing therapeutic responses. This study evaluates histologic components in AMR Methods Antibody-mediated was diagnosed using Antibody Working Group criteria and Banff component scoring, C4d staining were analyzed. Statistics included independent paired samples t test, χ2, Fisher exact, or the Wilcoxon-signed rank test. Fifty-five patients Early...
BK polyomavirus mostly manifests as polyomavirus-associated nephropathy (PyVAN) in kidney transplant patients and polyoma virus-associated hemorrhagic cystitis (PyVHC) bone marrow patients. PyVHC is only reported four cases the literature. Our patient had severe without renal involvement. We postulate that our patient's exposure to ifosfamide radiation 8 years prior transplantation might predispose him this disease.
Atypical hemolytic uremic syndrome (aHUS) is a genetic-based thrombotic microangiopathy (TMA) that mediated by the activation of alternative complement pathway. Heterozygous deletion in CFHR3-CFHR1 occurs 30% general population and has not been classically linked to aHUS. Post-transplant aHUS associated with high rate graft loss. Herein, we report our case series patients who developed after solid-organ transplantation.Five consecutive cases post-transplant were identified at center. Genetic...