A5102816669- Synthesis and biological activity
- Heme Oxygenase-1 and Carbon Monoxide
- Biochemical and Molecular Research
- Neutropenia and Cancer Infections
- Blood disorders and treatments
- Hemoglobinopathies and Related Disorders
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Reactions
- Hemoglobin structure and function
- Phenothiazines and Benzothiazines Synthesis and Activities
- Traumatic Brain Injury and Neurovascular Disturbances
- Pneumocystis jirovecii pneumonia detection and treatment
- Amino Acid Enzymes and Metabolism
- Fluorine in Organic Chemistry
- Neonatal Health and Biochemistry
- Quinazolinone synthesis and applications
- Synthesis and Biological Evaluation
- Carbohydrate Chemistry and Synthesis
- Synthesis and Reactions of Organic Compounds
- Parasitic Infections and Diagnostics
- Enzyme Structure and Function
- Organic Chemistry Cycloaddition Reactions
- Radiopharmaceutical Chemistry and Applications
- Cancer therapeutics and mechanisms
- Chemical Reactions and Mechanisms
Prolong Pharmaceuticals (United States)
2014-2017
University of Alberta
1986-2006
University of Massachusetts Chan Medical School
1991-1996
University of Lucknow
1980-1982
Tokushima University
1982
PEGylated carboxyhemoglobin bovine (SANGUINATE) is a dual action carbon monoxide releasing (CO)/oxygen (O2) transfer agent for the treatment of hypoxia. Its components inhibit vasoconstriction, decrease extravasation, limit reactive oxygen species production, enhance blood rheology, and deliver to tissues. Animal models cerebral ischemia, peripheral myocardial ischemia demonstrated SANGUINATE's efficacy in reducing infarct size, limiting necrosis from promoting more rapid recovery hind limb...
Treatment of sickle cell anemia is a challenging task and despite the well understood genetic biochemical pathway hemoglobin, current therapy continues to be limited symptomatic treatment pain, supplemental oxygen, antibiotics, red blood transfusions hydroxyurea. SANGUINATE carbon monoxide releasing molecule oxygen transfer agent under clinical development for comorbidities.An open-label randomized Phase Ib study was performed in adult patients. Two dose levels were compared hydroxyurea 24...
Abstract The endeavor to study desensitization in kidney transplantation has not been matched by an effort investigate strategies prevent sensitization. In this ( NCT 02437422), we investigated the safety, impact on sensitization, and pharmacokinetics of SANGUINATE SG ), a hemoglobin‐based oxygen carrier, as potential alternative packed red blood cells PRBC ) transplant candidates with end‐stage renal disease ESRD ). Ten subjects meeting inclusion/exclusion (I/E) criteria were planned...
Acetylation of pyridine-4-carbaldehyde methylthio(thiocarbonyl)hydrazone (1a) with acetic anhydride gave 4-acetyl-2-methylthio-5-(4-pyridyl)-4,5-dihydro-1,3,4-thiadiazole (2). Oxidation compound (2) 30% hydrogen peroxide in acid furnished 2-methylsulphonyl-5-(1-oxido-4-pyridyl),-1,3,4-thiadiazole (3a). 2-Alkylsulphonyl-1,3,4-thiadiazoles (3a–h) having 1-oxido-2-pyridyl, 1-oxido-3-3-pyridyl, 1-oxido-4-pyridyl, 1-oxido-2-quinolyl, and 1-oxido-4-quinolyl groups at the 5-position were obtained...
G proteins are molecular switches that use a cycle of GTP binding and hydrolysis to regulate wide variety cellular biochemical processes. Because the functional state these is allosterically determined by bound guanine nucleotides, nucleotide analogue with protein specificity might have pharmacological or value. The [alpha-32P]GTP four small immobilized on nitrocellulose was competed series analogues modifications at multiple sites. One analogue, N2-(p-n-butylphenyl)guanosine...
Abstract Die auf dem im Reaktionsschema skizzierten Weg synthetisierten Thiosemicarbazide (III) werden mit Natronlauge zu den Mercaptotriazolen (IV) cyclisiert und diese durch Umsetzung Chloressigsäure (V) weiter o‐Phenylendiamin (VII) in die Triazolylmercaptomethylbenzimidazolderivate (VIII) umgewandelt.
Abstract The reaction of [2‐ 14 C]‐2,4‐bis‐O‐(trimethylsilyl)uracil ( 2 ) with 3‐O‐acetyl‐5‐O‐benzoyl‐2‐deoxy‐2‐fluro‐α‐D‐arabinofuranosyl bromide 3 yielded the 3‐O‐acetyl‐5‐O‐benzoyl nucleoside 4 which was hydrolyzed methanolic ammonia to afford C]‐1‐(2‐deoxy‐2‐fluro‐β‐D‐arabinofuranosyl)uracil 5 in 55% radiochemical yield a specific activity mCi/mmol (74 MBq/mmol). molecular fluorine and chlorine glacial acetic acid at 25°C afforded 5‐fluoro‐ 6a 5‐chloro‐ 6b analogues...
Journal Article Synthesis and Pesticidal Activities of Some New Substituted 1,2,4-Triazoles Their Derivatives Get access Anil K Sen Gupta, Gupta Organic Chemistry Laboratories, University Lucknow, Lucknow 226007, India Search for other works by this author on: Oxford Academic Google Scholar Hemant Misra Agricultural Biological Chemistry, Volume 44, Issue 5, 1 May 1980, Pages 1009–1013, https://doi.org/10.1080/00021369.1980.10864094 Published: 01 1980 history Received: 29 August 1979
Abstract The synthesis is described of some new 2‐[3‐aryl(or cyclohexyl)‐6‐bromo(or 6,8‐dibromo)‐4‐oxo‐3 H ‐quinazolin‐2‐ylthio]‐ N ‐(4‐phenylthiazol‐2‐yl)acetamides and ‐(4‐aryl‐5‐methylthiazol‐2‐yl)acetamides. compounds were screened for their antibacterial, insecticidal anti‐acetylcholinesterase activities; most them exhibited significant activities.
e14085 Background: Anti-Neutropenia Factor - RHO (ANF-RHO) is a novel pegylated version of native human recombinant G-CSF protein. ANF-RHO has distinct biophysical and biological properties that produce pharmacokinetic (PK) pharmacodynamic (PD) profile as compared to pegfilgrastim may be ideally suited for treating febrile neutropenia. Methods: A phase I clinical study was conducted in healthy subjects assess the PK/PD ANF-RHO. The randomized, placebo controlled, double blind trial assessed...
e18086 Background: Patients who cannot receive blood transfusions in the presence of severe anemia can sustain significant morbidity and mortality. Religious beliefs hemolytic reactions are most common reasons for not transfusing a patient. Pegylated bovine carboxyhemoglobin (PEG-HbCO) has been used 5 such patients including patient developed reaction following stem cell transplantation. Methods: Five with hemoglobin (Hb) levels under 3.5 g/dL were treated repeated doses PEG-HbCO. Diagnoses...
Introduction: Sanguinate is a dual-action oxygen transfer and carbon monoxide-releasing agent with efficacy in animal models of focal brain ischemia established safety health volunteers. We performed dose-escalation study subarachnoid hemorrhage (SAH) patients at risk for delayed cerebral (DCI) to evaluate tolerability explore improving blood flow (CBF) flow-metabolism balance vulnerable regions. Methods: 12 subjects were studied over three dose tiers: 160mg/kg, 240 mg/kg, 320 close...
The nucleoside to nucleic acids pathways are attractive targets for molecular imaging of cell proliferation, radionuclide-based radiotherapy, following processes and drug design, development delivery. This paper describes the preparation several radiolabelled nucleosides comparitive study as markers tumour proliferation. 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-[ 36 Cl]chlorouracil (F[ Cl]ClAU) 1 was synthesized by reaction 1-(2-deoxy-2-fluoro-arabinofuranosyl)uracil (FAU) with Na Cl in...
Abstract Synthesis and Biological Activity of N′‐Aryloxyacetyl‐N 4 ‐aryl/cyclohexyl‐3‐thiosemicarbazides 1,2,4‐Triazoles.
Abstract Die aus Carbonylverbindungen (I) hergestellten Alkylthio‐thiocarbonylhydrazone (III) werden mit Dimethylsulfoxid und Acetanhydrid zu Disulfiden (IV) oxidiert.
Abstract Das Uracil‐zuckerepoxid (I) reagiert mit HF in Dioxan zu den beiden Spaltprodukten (II) und (III) sowie Uracil (IV).