A5049643664- Hepatitis C virus research
- Hepatitis B Virus Studies
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Polyomavirus and related diseases
- Hepatitis Viruses Studies and Epidemiology
- Full-Duplex Wireless Communications
- HIV, Drug Use, Sexual Risk
- Antenna Design and Analysis
- Immune Cell Function and Interaction
- Health and Medical Research Impacts
- Cannabis and Cannabinoid Research
- Energy Harvesting in Wireless Networks
- HIV-related health complications and treatments
- Global Health and Surgery
- Vibrio bacteria research studies
- Innovations in Medical Education
- Parvovirus B19 Infection Studies
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Viral-associated cancers and disorders
- Health Sciences Research and Education
- Mosquito-borne diseases and control
University of Cincinnati Medical Center
2016-2025
University of Cincinnati
2006-2025
Sefako Makgatho Health Sciences University
2020-2024
Sabin Vaccine Institute
2009-2022
National Health Laboratory Service
2020-2021
Weatherford College
2020
Centre For Digestive Diseases
2011-2012
Massachusetts General Hospital
2003-2007
Harvard University
1999-2006
American Society for Gastrointestinal Endoscopy
2006
ABSTRACT Emerging data have indicated that hepatitis C virus (HCV) subverts the host antiviral response to ensure its persistence. We previously demonstrated HCV protein expression suppresses type I interferon (IFN) signaling by leading reduction of phosphorylated STAT1 (P-STAT1). also core directly bound STAT1. However, detailed mechanisms which impacts IFN components not been fully clarified. In this report, we show interaction domain resides in N-terminal portion (amino acids [aa] 1 23)....
Breakthroughs in hepatitis C virus (HCV) treatment and rising rates of intravenous drug use have led to an increase the number organ donors who are HCV antibody-positive but serum nucleic acid test (NAT)-negative. The risk transmission from liver grafts these recipients is unknown. To estimate incidence transmission, we prospectively followed 26 consecutive antibody-negative (n = 25) or NAT-negative 1) transplant received a graft were between March 2016 2017. was considered occurred if...
The current AIDS pandemic represents the uneven spread of multiple genetically related subtypes (A to J) human immunodeficiency virus type 1 (HIV-1). Notably, HIV-1 E in southeast Asia and C sub-Saharan Africa are expanding faster likely greater global significance than B subtype prevalent United States Europe. While many studies have focused on genetic variation among structural genes, we chose conduct a comparative analysis long terminal repeats isolates report subtype-specific differences...
ABSTRACT Regulatory T cells (Treg) are a subpopulation of CD4 + characterized by the suppressive activity they exert on effector immune responses, including human immunodeficiency virus (HIV)-specific responses. Because Treg express CXCR4 and CCR5, represent potential targets for HIV; however, susceptibility to HIV infection is still unclear. We therefore performed an extensive study HIV, using lab strains primary isolates with either CCR5 or tropism. Furthermore, we quantified at early late...
Background. FIB-4 represents a noninvasive, composite index that is validated measure of hepatic fibrosis, which an important indicator liver disease. To date, there are limited data regarding fibrosis in women. Methods. was evaluated cohort 1227 women, and associations were univariate multivariate regression models among 4 groups subjects classified by their human immunodeficiency virus (HIV) hepatitis C (HCV) infection status. Results. The median scores 0.60 HIV-/HCV- 0.83 HIV-/HCV+ 0.86...
Background: Autoimmune and non-autoimmune thyroiditis frequently occur in persons with hepatitis C virus (HCV) infection. Treatment interferon alpha (IFNα) is also associated significant risk for the development of thyroiditis. To explore HCV–thyroid interactions at a cellular level, we evaluated whether human thyroid cell line (ML1) could be infected productively HCV vitro. Methods Results: ML1 cells showed robust surface expression major receptor CD81. Using highly sensitive,...
Abstract Background BK polyomavirus (BKPyV) is associated with symptomatic hemorrhagic cystitis after hematopoietic cell transplantation (HCT). Little known about the host immune response, effectiveness of antiviral treatment, or impact asymptomatic replication on long-term kidney function. Methods In children and young adults undergoing allogeneic HCT, we quantified BKPyV viruria viremia (pre-HCT at Months 1–4, 8, 12, 24 post-HCT) tested associations peak ≥10 000 ≥109 copies/mL estimated...
This study aimed to identify B-cell epitope candidates using multiple identification software and in silico analysis of the modeled B19 V protein against specific antibodies molecular docking dynamics simulation. Materials Methods: Full-length amino acid sequences VP1 were retrieved from NCBI. A consensus sequence was generated CLC viewer. Linear B cell epitopes identified Bepipred 2.0, ABCpred, LBTope. The linear synthesized validated V-specific antibodies. 3D model ITASSER server....
Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). In African populations, HCC frequently presents at an advanced stage with poor outcomes. We applied whole genome sequencing (WGS) to compare HBV genomes in individuals and without HCC. identified adults infection, complicating HCC, Cape Town, South Africa. generated WGS using pan-genotypic probe-based enrichment followed by Illumina sequencing. Compared the non-HCC group, patients were more...
Background The illicit use of synthetic opioids such as fentanyl has led to a serious public health crisis in the US. People with opioid disorder are more likely contract infections HIV and viral hepatitis experience severe disease. While several drugs abuse known enhance replication suppress immunologic responses, effects on pathogenesis have not been investigated thoroughly. Thus, we examined impact chemokine receptor expression U937 cell line monocyte-derived macrophages (MDMs). Methods...
Objectives/Goals: Team science (TS) competency is important for translational team collaboration. However, there are few educators available to assist teams. Asynchronous learning an effective strategy delivering TS content. The goal of this project expand education by providing online access our learners using modules. Methods/Study Population: Collaboration and Science (CaTS) at the University Cincinnati provides a robust training program. As need gains recognition, CaTS has received...
Objectives/Goals: Academic research centers struggle to recruit and retain a diverse, competent clinical translational science (CTS) workforce. The professional career pathway is particularly underrecognized among undergraduates, despite offering multiple opportunities. Methods/Study Population: To address these challenges, two undergraduate outreach programs were developed. First, an certificate program in CTS (UC-CTS) was designed equip students with the skills knowledge needed enter...
We developed hepatitis C virus (HCV) core-E1-E2 and HCV core transgenic mice on a common genetic background to assess the contribution of structural proteins hepatocarcinogenesis. Eight-week-old core-E1-E2, core, nontransgenic inbred FVB×C57Bl/6 were treated with diethylnitrosamine (DEN) sacrificed at 32 weeks old. Proliferation apoptosis assessed by immunohistochemistry. The effect viral was evaluated in HepG2 cells which induced anti-Fas antibody. HCCs identified majority DEN-treated from...
It has been speculated that hepatitis C virus (HCV) replicates in peripheral-blood mononuclear cells (PBMCs), which, therefore, may be a site for interaction with human immunodeficiency (HIV). We used strand-specific real-time polymerase chain reaction to detect HCV RNA 28 HCV-monoinfected and 20 HIV/HCV–coinfected women. At the first visit, positive-strand was detected serum samples from 89% of women, whereas PBMC 32% 55% respectively. After initiation antiretroviral therapy, women were...