A5044155951- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Nanopore and Nanochannel Transport Studies
- Renal Transplantation Outcomes and Treatments
- Lipid Membrane Structure and Behavior
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
- RNA Interference and Gene Delivery
- Legionella and Acanthamoeba research
- Blood donation and transfusion practices
- Bacterial Identification and Susceptibility Testing
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Cerebrospinal fluid and hydrocephalus
- Dermatological diseases and infestations
- Insect Utilization and Effects
- Clostridium difficile and Clostridium perfringens research
- Long-Term Effects of COVID-19
- X-ray Spectroscopy and Fluorescence Analysis
- Entomological Studies and Ecology
- Streptococcal Infections and Treatments
- Organ Transplantation Techniques and Outcomes
- Spectroscopy and Laser Applications
- Amoebic Infections and Treatments
University of Cincinnati Medical Center
2019-2025
University of Cincinnati
2014-2021
Vanderbilt University
2001-2013
National Institute on Alcohol Abuse and Alcoholism
2004
National Institutes of Health
2004
Breakthroughs in hepatitis C virus (HCV) treatment and rising rates of intravenous drug use have led to an increase the number organ donors who are HCV antibody-positive but serum nucleic acid test (NAT)-negative. The risk transmission from liver grafts these recipients is unknown. To estimate incidence transmission, we prospectively followed 26 consecutive antibody-negative (n = 25) or NAT-negative 1) transplant received a graft were between March 2016 2017. was considered occurred if...
Objectives: The aim of this study was to assess the 1-year safety and effectiveness HBV Nucleic Acid Test positive (HBV NAT+) allografts in seronegative kidney transplant (KT) liver (LT) recipients. Summary Background Data: Despite an ongoing organ shortage, utilization NAT+ into recipients has not been investigated. Methods: From January 2017 October 2020, a prospective cohort conducted among consecutive KT LT at single institution. Primary endpoints were post-transplant viremia, graft...
Lipid bilayers were deposited inside the 0.2 μm pores of anodic aluminum oxide (AAO) filters by extrusion multilamellar liposomes and their properties studied 2H, 31P, 1H solid-state NMR. Only first bilayer adhered strongly to inner surface pores. Additional layers washed out easily a flow water as demonstrated magic angle spinning NMR experiments with addition Pr3+ ions shift accessible lipid headgroup resonances. A 13 mm diameter Anopore filter 60 thickness oriented approximately 2.5 ×...
Hepatitis C (HCV) disease transmission from the use of HCV antibody-positive and nucleic acid test-negative (HCV Ab+/NAT-) kidneys have been anecdotally reported to be absent. We prospectively analyzed kidney transplant (KT) outcomes Ab+/NAT- donors naïve recipients under T-cell depleting early steroid withdrawal immunosuppression. Allografts 40 were transplanted 52 Ab- between July 2016 February 2018. Thirty-three (82.5%) met Public Health Service (PHS) increased risk criteria. De novo...
ABSTRACT. Tuberculosis (TB) can cause significant morbidity and mortality among solid organ transplant (SOT) recipients, including disseminated disease. Most TB cases after SOT occur in kidney although data about this population are sparse. may present atypically immunocompromised patients, underscoring why physicians must maintain high clinical suspicion when pertinent epidemiological risk factors present, birth or former residence a country with endemic TB. We describe unique case of...
Background. Histoplasmosis causes severe disease in patients with defects of cell-mediated immunity. It is not known whether outcomes vary related to the type immunodeficiency or class antifungal treatment. Methods. We reviewed cases active histoplasmosis that occurred at Vanderbilt University Medical Center from July 1999 June 2012 human virus (HIV) infection, a history transplantation, tumor necrosis factor (TNF)-α inhibitor use. These groups were compared for differences clinical...
BackgroundThe coronavirus disease 2019 (COVID-19) pandemic has seen transplant volume decrease nationwide, resulting in a 2.2-fold increase waitlist mortality. In particular, solid organ patients are subjected to increased morbidity and mortality from infection. the face of these challenges, centers need develop innovative protocols ensure high-quality care.MethodsA multidisciplinary protocol was developed that included following: virtual selection meetings, negative donors, pretransplant...
The absorption spectra of I2 and Br2 dissolved in n-heptane CCl4 are recorded with high precision the visible-near-IR spectral range, at temperatures between 15° 50 °C. decomposed into three contributing transitions (1Πu ← X, B0+u3Π A 1u3Π X) through simultaneous least-squares fitting T-dependent data. main results analysis as follows. (1) In weakest X band is virtually identical shape intensity these solvents gas phase, but small blue shifts solution. (2) ∼20% increased solution appears to...