A5053550187- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Pancreatic and Hepatic Oncology Research
- Breast Cancer Treatment Studies
- Colorectal Cancer Treatments and Studies
- Organ and Tissue Transplantation Research
- Gastric Cancer Management and Outcomes
- Congenital Anomalies and Fetal Surgery
- Vascular Malformations and Hemangiomas
- Breast Lesions and Carcinomas
- Vascular Anomalies and Treatments
- Sarcoma Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Viral-associated cancers and disorders
- Nutrition and Health in Aging
- Gallbladder and Bile Duct Disorders
- Gastrointestinal Tumor Research and Treatment
- Acute Kidney Injury Research
- Cardiac tumors and thrombi
University of Rochester
2021-2023
University of Rochester Medical Center
2022
Cleveland Clinic
2018-2021
Cleveland Clinic Lerner College of Medicine
2020-2021
St James's University Hospital
2012-2020
Wellcome Trust
2020
University of Leeds
2013-2018
University Hospitals Coventry and Warwickshire NHS Trust
2016
NHS Blood and Transplant
2014
Leeds Teaching Hospitals NHS Trust
2013
Background Lymph node (LN) status is an important predictor of survival following resection perihilar cholangiocarcinoma (PHCCA). Controversies still exist with regard to the prognostic value optimum extent lymphadenectomy, total number nodes removed, LN ratio (LNR) and neutrophil–lymphocyte (NLR) on overall (OS) disease-free (DFS) PHCCA resection. Methods From 1994 2010, 84 PHCCAs were resected; 78 are included in this analysis. Kaplan–Meier curves studied using log-rank statistics assess...
Objective: To define benchmark cutoffs for redo liver transplantation (redo-LT). Background: In the era of organ shortage, redo-LT is frequently discussed in terms expected poor outcome and wasteful resources. However, there a lack data to reliably evaluate outcomes after redo-LT. Methods: We collected on between January 2010 December 2018 from 22 high-volume transplant centers. Benchmark cases were defined as recipients with model end stage disease (MELD) score ≤25, absence portal vein...
Background: Butyrate, a short-chain fatty acid (SCFA) formed by the fermentation of complex carbohydrates bacteria in colon, is main source nutrition for colonocytes. The aim this experiment was to investigate effect butyrate on healing colonic anastomosis rat model. Materials and Methods: Forty male Wistar rats were fed fibre-free diet 2 days. They then underwent laparotomy, transection, both left right with defunctioning caecostomy. animals randomly assigned receive or saline enemas from...
Abstract Purpose The current treatment outcomes in cholangiocarcinoma are poor with cure afforded only by surgical extirpation. efficacy of targeting the tumoural endothelial marker CD105 cholangiocarcinoma, as a basis for potential microbubble-based treatment, is unknown and was explored here. Methods Tissue expression quantified using immunohistochemistry 54 perihilar samples from patients who underwent resection single centre over ten-year period, analysed against clinicopathological...
Platforms using valid molecular targets can provide concurrent diagnostic and treatment (theragnostic) options in perihilar cholangiocarcinoma (PHC). Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker the biliary secretome of PHC. Its potential as theragnostic target its prognostic significance this cancer was, therefore, explored.In-vitro studies were used to determine NGAL localization several cell lines. Tissue expression was quantified PHC resection cases from 2000-2010 by...
Background. Calcineurin inhibitor (CNI)-based immunosuppression in liver transplantation (LTx) is associated with acute and chronic deterioration of kidney function. Delaying CNI initiation by using induction rabbit antithymocyte globulin (rATG) may provide kidneys adequate time to recover from a perioperative insult reducing the risk early post-LTx renal deterioration. Methods. This was an open-label, multicenter, randomized controlled clinical trial comparing use rATG delayed (d 10)...
Rates of withdrawal life-sustaining treatment are higher among critically ill pediatric patients compared to adults. Therefore, livers from donation after circulatory death (pDCD) could improve graft organ shortage and waiting time for listed patients. As knowledge on the utilization pDCD is limited, this study used US national registry data (2002-2017) estimate prognostic impact in both adult liver transplant (LT).In LT, short-term (1-year) long-term (overall) survival (GS) between (aDCD)...
Abstract Background Ascertaining the origin of large tumors located in region pancreas head and adjacent mesocolon can pose a challenge preoperatively. En bloc pancreatoduodenectomy with hemicolectomy is often required towards curative tumor resection (R0) malignant this region. Case presentation Herein we report case 48-year-old man two contiguous masses each 5 cm size, pancreatic head. The were detected incidentally by abdominal ultrasonography at an annual health check. Endoscopic...
<h3>Introduction</h3> Lymph node status is an important predictor of survival following resection for hilar cholangiocarcinoma (HCCA). Controversies still exist regarding the extent lymphadenectomy and whether extended lymph dissection improves outcome. This study aims to evaluate prognostic value total number nodes removed positive lymphnode ratio (LNR) on overall disease-free in patients undergoing HCCA. <h3>Methods</h3> From 1994 2010, 84 HCCA were resected at our Institution....
Donation after circulatory death (DCD) liver transplantation improves deceased donor use and decreases waitlist burden, albeit at an increased risk of biliary complications inferior graft survival. Employing vascular inflow measurements intraoperatively permits allograft prognostication. However, its in DCD is hitherto largely unknown further explored here. patient records a single center from 2005 to 2018 were retrospectively scrutinized. Intraoperative flow data relevant parameters...
Abstract Objective In the era of organ shortage, redo liver transplantation (reLT) is frequently discussed in terms expected poor outcome, high cost and therefore wasteful resources. However, there a lack benchmark data to reliably assess outcomes after reLT. The aim this study was define ideal reLT case, establish clinically relevant values for best achievable outcome Methods We collected on between January 2010 December 2018 from 22 volume transplant centers three continents. Benchmark...