A5005023023- Celiac Disease Research and Management
- COVID-19 Clinical Research Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Viral gastroenteritis research and epidemiology
- Parathyroid Disorders and Treatments
- Vascular Tumors and Angiosarcomas
- Polyomavirus and related diseases
- Neuroendocrine Tumor Research Advances
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Digestive system and related health
- COVID-19 and healthcare impacts
- Metabolism and Genetic Disorders
- Cardiac tumors and thrombi
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Antenna Design and Analysis
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Dermatological and COVID-19 studies
- SARS-CoV-2 and COVID-19 Research
- Hemoglobinopathies and Related Disorders
Riverside Community Hospital
2025
Columbia University
2020-2024
Columbia University Irving Medical Center
2020-2022
New York Hospital Queens
2020
NewYork–Presbyterian Hospital
2020
Presbyterian Hospital
2019
Abstract Objectives Although diffuse alveolar damage, a subtype of acute lung injury (ALI), is the most common microscopic pattern in coronavirus disease 2019 (COVID-19), other pathologic patterns have been described. The aim study was to review autopsies from COVID-19 decedents evaluate spectrum pathology and correlate results with clinical, laboratory, radiologic findings. Methods A comprehensive quantitative 40 postmortem examinations performed. were categorized as follows: “major” when...
We present a case of COVID-19 hepatitis in living donor liver allograft recipient whose subsequently tested positive for COVID-19. The patient is female infant with biliary atresia (failed Kasai procedure). She recovered well, improving function tests 4 days. On postoperative day the developed respiratory distress and fever. testing (polymerase chain reaction) was positive. Liver test results increased approximately 5-fold. biopsy showed moderate acute prominent clusters apoptotic...
How group 3 innate lymphoid cells (ILC3s) regulate mucosal protection in the presence of T remains poorly understood. Here, we examined ILC3 function intestinal immunity using ILC3-deficient mice that maintain endogenous cells, helper 17 (T H 17) and secondary organs. ILC3s were dispensable for generation 22 cell responses to commensal pathogenic bacteria, absence did not affect IL-22 production by CD4 before or during infection. However, despite IL-22–producing ILC3-derived required...
Abstract Objectives Special AT-rich binding protein 2 (SATB2) immunohistochemistry (IHC) has high sensitivity and specificity for colorectal adenocarcinoma (CRC), but data on its expression in specific subsets of pulmonary, gastric, small bowel, pancreatobiliary adenocarcinomas (ADCAs) are relatively limited or discordant. We assessed SATB2 a large cohort ADCAs from these sites to determine reliability distinguishing CRC them. Methods IHC was performed 335 neoplasms, including 40 lung ADCAs,...
We describe the first report to our knowledge of cutaneous and systemic pathogenicity human polyomavirus 9 in solid organ transplant recipients.Three recipients developed a widespread, progressive, violaceous, hyperkeratotic skin eruption. All died from pulmonary multiorgan failure around 1 year onset rash. Routine clinical diagnostic testing could not identify any causative agent; therefore, samples autopsies were investigated for novel pathogens using high-throughput sequencing.This case...
Celiac Disease (CD) is characterized by gluten intolerance in genetically predisposed individuals. High disease prevalence, absence of a cure, and low diagnosis rates make this public health problem. The CD predominantly relies on recognizing characteristic mucosal alterations the small intestine, such as villous atrophy, crypt hyperplasia, intraepithelial lymphocytosis. However, these changes are not entirely specific to overlap with Non-Celiac Duodenitis (NCD) due various etiologies. We...
Light chain deposition disease, characterized by nonamyloidogenic deposits of immunoglobulin light chains, is rare in the lung and possibly underdiagnosed due to low clinical suspicion lack readily accessible tests. We encountered a case pulmonary disease (PLCDD) which appeared crimson red with Masson trichrome (MT) stain salmon pink sulfated Alcian blue (SAB) stain. This prompted us characterize series PLCDD cases assess utility MT SAB stains distinguish them from amyloidosis. From...
Abstract We describe the case of a 9-week-old female infant Ashkenazi Jewish descent who presented with failure to thrive, vomiting, and persistent jaundice. Laboratory tests showed positive urine reducing substances as well an abnormal amino acid profile, increased arginine, threonine, methionine, tyrosine, lysine, grossly elevated citrulline levels. Liver biopsy demonstrated presence cholestatic hepatitis mixed steatosis siderosis. Based on aforementioned findings, preliminary diagnosis...
Abstract Extramedullary hematopoiesis (EMH) is characterized by the expansion of hematopoietic tissue outside bone marrow niche. It occurs when function insufficient and typically presents with generalized hepatosplenomegaly. We describe a rare case mass-forming EMH that presented as two intrahepatic lesions, radiologically well-demarcated nonenhancing on computed tomography. On magnetic resonance imaging, lesions appeared T1 hypointense T2 hyperintense restricted diffusion. The were...
Abstract Purpose: Progesterone receptor (PR) is expressed strongly in a subset of neuroendocrine cells the pancreas. Tamoxifen has long been used adjuvant endocrine therapy steroid hormone receptor–positive breast cancer, and currently clinical trials are assessing its use pancreatic tumors (NET) that show variable PR expression. Prior studies have reported status as “positive” or “negative,” using 1% 10% positive nuclei cutoff. In this study, we assessed immunohistochemical expression...