A5022069492- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Respiratory viral infections research
- Adipose Tissue and Metabolism
- Sleep and related disorders
- SARS-CoV-2 and COVID-19 Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Antimicrobial Peptides and Activities
- vaccines and immunoinformatics approaches
- COVID-19 Pandemic Impacts
- Helicobacter pylori-related gastroenterology studies
- Long-Term Effects of COVID-19
- Neural dynamics and brain function
- Regulation of Appetite and Obesity
- Vector-borne infectious diseases
- Toxin Mechanisms and Immunotoxins
- Biological Control of Invasive Species
- Supply Chain Resilience and Risk Management
- Cystic Fibrosis Research Advances
- Video Surveillance and Tracking Methods
- Mindfulness and Compassion Interventions
- Full-Duplex Wireless Communications
- Biometric Identification and Security
University of Kentucky
2014-2023
Columbia University
2020-2022
National Institute of Technology Warangal
2020
Yale University
2018-2019
University of California, San Diego
2013
National University of Singapore
2005
Serodiagnosis of SARS-CoV-2 infection is impeded by immunological cross-reactivity among the human coronaviruses (HCoVs): SARS-CoV-2, SARS-CoV-1, MERS-CoV, OC43, 229E, HKU1, and NL63. Here we report identification humoral immune responses to peptides that may enable discrimination between exposure other HCoVs. We used a high-density peptide microarray plasma samples collected at two time points from 50 subjects with confirmed qPCR, in 2004-2005 11 IgG antibodies seasonal (HCoV), 10 healthy...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease characterized by unexplained physical fatigue, cognitive sensory dysfunction, sleeping disturbances, orthostatic intolerance, gastrointestinal problems. People with ME/CFS often report prodrome consistent infections. Using regression, Bayesian enrichment analyses, we conducted targeted untargeted metabolomic analysis of plasma from 106 cases 91 frequency-matched healthy controls. Subjects in the...
The practice of social distancing is imperative to curbing the spread contagious diseases and has been globally adopted as a non-pharmaceutical prevention measure during COVID-19 pandemic. This work proposes novel framework named SD-Measure for detecting from video footages. proposed leverages Mask R-CNN deep neural network detect people in frame. To consistently identify whether practiced interaction between people, centroid tracking algorithm utilised track subjects over course footage....
People with diabetes are more likely to experience sleep disturbance than those without. Sleep can cause daytime sleepiness in diabetic patients, which may impair their performance or even lead workplace injuries. Therefore, restoring the normal sleep-wake cycle is critical for patients who sleepiness. Previous data on a mouse model, db/db mice, have demonstrated that total time and fragmentation increased daily rhythm of attenuated. Accumulating evidence has shown active time-restricted...
The use of facial masks in public spaces has become a social obligation since the wake COVID-19 global pandemic and identification can be imperative to ensure safety. Detection video footages is challenging task primarily due fact that themselves behave as occlusions face detection algorithms absence landmarks masked regions. In this work, we propose an approach for detecting videos using deep learning. proposed framework capitalizes on MTCNN model identify faces their corresponding present...
Abstract Background Pneumococcus is exposed to a variety of temperature and oxygen levels in the upper respiratory tract as it invades lung, tissues, blood. We sought determine effect environmental variability on growth vitro assess between strains. evaluated 256 isolates representing 53 serotypes, recovered from healthy carriers disease patients. Strains were grown at range temperatures, anaerobically or ambient air with catalase, monitored by reading optical density. Regression models...
We describe the first report to our knowledge of cutaneous and systemic pathogenicity human polyomavirus 9 in solid organ transplant recipients.Three recipients developed a widespread, progressive, violaceous, hyperkeratotic skin eruption. All died from pulmonary multiorgan failure around 1 year onset rash. Routine clinical diagnostic testing could not identify any causative agent; therefore, samples autopsies were investigated for novel pathogens using high-throughput sequencing.This case...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease that characterized by unexplained physical unrelieved rest. Symptoms also include cognitive sensory dysfunction, sleeping disturbances, orthostatic intolerance, gastrointestinal problems. A clinically similar to ME/CFS has been reported following well-documented infections with the coronaviruses SARS-CoV MERS-CoV. At least 10% of COVID-19 survivors develop post acute sequelae SARS-CoV-2...
Immunocompromised individuals are at risk of prolonged SARS-CoV-2 infection due to weaker immunity, co-morbidities, and lowered vaccine effectiveness, which may evolve highly mutated variants SARS-CoV-2. Nonetheless, limited data available on the immune responses elicited by infection, reinfections, vaccinations with emerging in immunocompromised patients. We analyzed clinical samples that were opportunistically collected from eight for mutations genomes, neutralizing antibody (NAb) titers...
Abstract Sleep is a critical process that well-conserved across mammalian species, and perhaps most animals, yet its functions underlying mechanisms remain poorly understood. Identification of genes pathways can influence sleep may shed new light on these functions. Genomic screens enable the detection previously unsuspected molecular processes sleep. In this study, we report results from large-scale phenotyping study sleep-wake parameters for population single-gene knockout mice. Sleep-wake...
Background Sleep is critical to well-being and yet the functions regulation of sleep are poorly understood. Genomic approaches identify genes that influence may provide insight into these processes. Our current study employs a non-invasive, high-throughput piezoelectric system utilizing breathing pattern assess sleepwake phenotypes in large population control single-gene knockout mice; recorded as part Knockout Mouse Phenotype Program (KOMP2) at The Jackson Laboratory, which turn IMPC...
Abstract Serodiagnosis of SARS-CoV-2 infection is impeded by immunological cross-reactivity to the human coronaviruses (HCoV) SARS-CoV-2, SARS-CoV-1, MERS-CoV, OC43, 229E, HKU1, and NL63. Here we report identification humoral immune responses other HCoV peptides that can be used detect asymptomatic, mild and, severe infections, may enable discovery biomarkers for immunity following or vaccination.
Pneumococcus is a diverse pathogen, with >90 serotypes, each of which has distinct polysaccharide capsule. Pneumococci can switch capsules, evading vaccine pressure. Certain serotype pairs are more likely to occur on the same genetic background as results switching, but drivers these patterns not well understood.We used PubMLST and Global Pneumococcal Sequencing Project databases quantify number lineages different together. We also quantified diversity serotype. Regression model were...
Anaplasma phagocytophilum and Babesia microti are emerging tick-borne pathogens in the United States. Although active infection is typically diagnosed by direct diagnostic tests, such as blood smear or polymerase chain reaction assay, serologic assays can be helpful to identify past infections, use of acute plus convalescent testing potentially recent infections. We employed a peptide array select sets linear peptides for diagnosis infections with A. B. microti. Three optimal were selected...
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01866-z
Abstract Background Pneumococcus, a bacterium that typically resides in the nasopharynx, is exposed to variety of temperature and oxygen levels upper respiratory tract as it invades lung, tissues, blood. The response these variations likely varies by strain could influence fitness its virulence. We sought determine effect environmental variability on growth characteristics pneumococcus evaluate correlations between strains biological epidemiological characteristics. Methods evaluated 256...
Materials and methods Using a two-pronged approach to solve this problem, publicly available microarray data from NCBI GEO (National Center for Biotechnology Information – Gene Expression Omnibus) database was used develop list of sleep-related genes traits interest. The were analyzed using R Bioconductor custom Perl scripts. then matched with the in QTL (Quantitative Trait Loci) trait. within chromosomal region matching any considered as potential candidates causing variations quantitative
Undergraduate students suffer from stress and attention problems throughout their academic career.This is a great time for to learn new skill; meditation practices have been shown improve mental physical health our activity can introduce them this beneficial practice.Utilizing the learning-cycle approach, we had first engage with problem, explore interpretations, conduct experiment, then interpret explain results.This short investigates impact of focused-breathing on using psychomotor...
Weeds have a direct effect on crop yields when they compete with the for nutrients, moisture and light. It is found infested variety of ways, which often cause losses in grain yield ranging from 20-30%. During this study dominance, diversity species composition weeds Rice field Doon Valley was studied. The conducted various Villages viz. Babugarh, Doctorganj Bawanpur Vikasnagar block month August September. A total 24 rice fields were recorded selected sites. Lindernia anagallis, Cyperus...
ABSTRACT Background Pneumococcus is a diverse pathogen, with >90 serotypes, each of which has distinct polysaccharide capsule. Pneumococci can switch capsules, evading vaccine pressure. Certain serotype pairs are more likely to switch, but the drivers these patterns not well understood. Methods We used PubMLST and Global Pneumococcal Sequencing (GPS) databases quantify number genetic lineages on different co-occur. also quantified diversity serotype. Regression models evaluated...