A5074003972- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Viral Infections and Immunology Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Malaria Research and Control
- Chronic Disease Management Strategies
- Bacterial Infections and Vaccines
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Mobile Health and mHealth Applications
- Vector-borne infectious diseases
- Primary Care and Health Outcomes
- Disaster Response and Management
- Cancer Research and Treatments
- Insect and Pesticide Research
- Full-Duplex Wireless Communications
- Viral Infections and Outbreaks Research
- vaccines and immunoinformatics approaches
- Immunodeficiency and Autoimmune Disorders
- Insect symbiosis and bacterial influences
- Vector-Borne Animal Diseases
- Viral gastroenteritis research and epidemiology
Columbia University
2018-2023
Columbia University Irving Medical Center
2022
Institute of Infection and Immunity
2018-2019
The presence in cerebrospinal fluid of antibodies to EV peptides at higher levels than non-AFM controls supports the plausibility a link between infection and AFM that warrants further investigation has potential lead strategies for diagnosis prevention disease.
Zika virus (ZIKV) is implicated in fetal stillbirth, microcephaly, intracranial calcifications, and ocular anomalies following vertical transmission from infected mothers. In adults, infection may trigger autoimmune inflammatory polyneuropathy. Transmission most commonly follows the bite of Aedes mosquitoes but also occur through sexual intercourse or receipt blood products. Definitive diagnosis detection viral RNA possible serum plasma within 10 days disease onset, whole 3 weeks semen for...
Serodiagnosis of SARS-CoV-2 infection is impeded by immunological cross-reactivity among the human coronaviruses (HCoVs): SARS-CoV-2, SARS-CoV-1, MERS-CoV, OC43, 229E, HKU1, and NL63. Here we report identification humoral immune responses to peptides that may enable discrimination between exposure other HCoVs. We used a high-density peptide microarray plasma samples collected at two time points from 50 subjects with confirmed qPCR, in 2004-2005 11 IgG antibodies seasonal (HCoV), 10 healthy...
Abstract Brazil, which is hyperendemic for dengue virus (DENV), has had recent Zika (ZIKV) and (CHIKV) Chikungunya outbreaks. Since March 2016, CHIKV the arbovirus infection most frequently diagnosed in Rio de Janeiro. In analysis of 1835 syndromic patients, screened by real time RT-PCR, 56.4% cases were attributed to CHIKV, 29.6% ZIKV, 14.1% DENV-4. Sequence analyses from sixteen samples revealed that East-Central-South-African ( ECSA) genotype been circulating Brazil since 2013 [95%...
<sec> <title>BACKGROUND</title> Despite digital mental health services growing at a rapid pace to address global needs, there exist challenges of low engagement and attrition. Ensuring continuity care in the context can positively impact delivery adherence treatment, thus establishing interventions (DMHIs) as viable option for support. </sec> <title>OBJECTIVE</title> This study aimed examine adjunct app features Wysa, their ability promote with text-based coaching sessions....
<sec> <title>BACKGROUND</title> Despite digital mental health services growing at a rapid pace to address global needs, there exist challenges of low engagement and attrition. Ensuring continuity care in the context can positively impact delivery adherence treatment, thus establishing interventions (DMHIs) as viable option for support. </sec> <title>OBJECTIVE</title> This study aimed examine adjunct app features Wysa, their ability promote with text-based coaching sessions....
Borrelia miyamotoi is an emerging tick-borne spirochete transmitted by ixodid ticks. Current serologic assays for B. are impacted genetic similarities to other and limited understanding of optimal antigenic targets. In this study, we employed the TBD-Serochip, a peptide array platform, identify new linear targets detection miyamotoi. We examined wide range suspected antigens identified 352 IgM 91 IgG reactive peptides, with majority mapping variable membrane proteins. These included peptides...
We describe the first report to our knowledge of cutaneous and systemic pathogenicity human polyomavirus 9 in solid organ transplant recipients.Three recipients developed a widespread, progressive, violaceous, hyperkeratotic skin eruption. All died from pulmonary multiorgan failure around 1 year onset rash. Routine clinical diagnostic testing could not identify any causative agent; therefore, samples autopsies were investigated for novel pathogens using high-throughput sequencing.This case...
Abstract Background The second largest Ebola virus disease (EVD) outbreak began in the Democratic Republic of Congo July 2018 North Kivu Province. Data suggest is not epidemiologically linked to Equateur Province, and that independent introduction (EBOV) into humans occurred. We tested for antibodies ebolaviruses febrile patients seeking care Province prior EVD outbreak. Methods Patients were enrolled between May 2017 April 2018, before declared start eastern DRC. Questionnaires administered...
Immunocompromised individuals are at risk of prolonged SARS-CoV-2 infection due to weaker immunity, co-morbidities, and lowered vaccine effectiveness, which may evolve highly mutated variants SARS-CoV-2. Nonetheless, limited data available on the immune responses elicited by infection, reinfections, vaccinations with emerging in immunocompromised patients. We analyzed clinical samples that were opportunistically collected from eight for mutations genomes, neutralizing antibody (NAb) titers...
Abstract Serodiagnosis of SARS-CoV-2 infection is impeded by immunological cross-reactivity to the human coronaviruses (HCoV) SARS-CoV-2, SARS-CoV-1, MERS-CoV, OC43, 229E, HKU1, and NL63. Here we report identification humoral immune responses other HCoV peptides that can be used detect asymptomatic, mild and, severe infections, may enable discovery biomarkers for immunity following or vaccination.
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01866-z
Abstract Brazil, which is hyperendemic for dengue virus (DENV), has had recent Zika (ZIKV) and (CHIKV) Chikungunya outbreaks. Since March 2016, CHIKV the arbovirus infection most frequently diagnosed in Rio de Janeiro. In analysis of 1835 syndromic patients, screened by real time RT-PCR, 56.4% cases were attributed to CHIKV, 29.6% ZIKV, 14.1% DENV-4. Sequence analyses from sixteen samples revealed that East-Central-South-African ( ECSA) genotype been circulating Brazil since 2013 [95%...
Unbiased high-throughput sequencing (HTS) has enabled new insights into the diversity of agents implicated in central nervous system (CNS) infections. The addition positive selection capture methods to HTS enhanced sensitivity while reducing costs and complexity bioinformatic analysis. Here we report use virus based for vertebrate viruses (VirCapSeq-VERT) bacterial (BacCapSeq) investigating CNS
Abstract Borrelia miyamotoi is an emerging tick-borne spirochete transmitted by Ixodid ticks. Current serologic assays for B. are impacted genetic similarities to other and limited understanding of optimal antigenic targets. In this study, we employed the TBD-Serochip, a peptide array platform, identify new linear targets detection . We examined wide range suspected antigens identified 352 IgM 91 IgG reactive peptides, with majority mapping variable membrane proteins. These included peptides...