A5073617035- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Child and Animal Learning Development
- Animal Vocal Communication and Behavior
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Corneal Surgery and Treatments
- Language Development and Disorders
- Ocular Infections and Treatments
- CRISPR and Genetic Engineering
- Infant Health and Development
- Animal Behavior and Reproduction
- Allergic Rhinitis and Sensitization
- Multisensory perception and integration
- Language and cultural evolution
- Neuroendocrine regulation and behavior
- Primate Behavior and Ecology
- Speech and dialogue systems
- BRCA gene mutations in cancer
- Early Childhood Education and Development
- Marine animal studies overview
- Phonetics and Phonology Research
- Epilepsy research and treatment
- Child Development and Digital Technology
- Connective Tissue Growth Factor Research
Cornell University
2015-2025
Tufts University
2002-2017
Tufts Medical Center
2010-2017
Integrated BioTherapeutics (United States)
2016
Kala Pharmaceuticals (United States)
2016
California Northstate University
2016
Sall Research Medical Center
2016
Wolstan & Goldberg Eye Associates
2016
Abrams Eye Institute
2016
Medical Center Ophthalmology Associates
2016
Birdsong is considered a model of human speech development at behavioral and neural levels. Few direct tests the proposed analogs exist, however. Here we test mechanism phonological in infants that based on social shaping, selective learning process first documented songbirds. By manipulating mothers' reactions to their 8-month-old infants' vocalizations, demonstrate features babbling are sensitive nonimitative stimulation. Contingent, but not noncontingent, maternal behavior facilitates...
Infants' prelinguistic vocalizations are rarely considered relevant for communicative development. As a result, there few studies of mechanisms underlying developmental changes in vocal production. Here we report the first evidence that caregivers'speech to babbling infants provides crucial, real-time guidance development vocalizations. Mothers 9.5-month-old were instructed provide models production timed be either contingent or noncontingent on their infants' babbling. Infants given...
Few studies have focused on mechanisms of developmental change during the prelinguistic period. The lack focus early vocal development is surprising given that maternal responsiveness to infants first two years has been found influence later language development. In addition, in a variety species, social feedback essential for Previous research demonstrated vocalizations influenced production more developmentally advanced vocalizations, suggesting effects may start phase; however, because...
The early noncry vocalizations of infants are salient social signals. Caregivers spontaneously respond to 30%–50% these sounds, and their responsiveness infants’ prelinguistic facilitates the development phonology speech. Have learned that influence behavior partners? If they have, should show an extinction burst in vocalizing when adults temporarily stop responding infant vocalizations. Thirty‐eight 5‐month‐olds were tested still‐face paradigm with unfamiliar adult. When adult assumed a...
Hepatic ischemia/reperfusion (I/R) injury associated with liver transplantation and hepatic resection is characterized by hepatocellular damage a deleterious inflammatory response. In this study, we examined whether receptor for advanced glycation end product (RAGE) activation linked to mechanisms accentuating inflammation on I/R in murine model of total ischemia. Animals treated soluble RAGE (sRAGE), the extracellular ligand-binding domain RAGE, displayed increased survival after compared...
Two studies illustrate the functional significance of a new category prelinguistic vocalizing-object-directed vocalizations (ODVs)-and show that these sounds are connected to learning about words and objects. Experiment 1 tested 12-month-old infants' perceptual objects elicited ODVs. Fourteen were recorded as they explored novel Infants learned visual features most ODVs but not fewest vocalizations. 2 assessed role in word-object associations. Forty infants aged 11.5 months played with...
What is the social function of babbling? An important prelinguistic vocalizing may be to elicit parental behavior in ways that facilitate infant's own learning about speech and language. Infants use feedback their babbling learn new vocal forms, but microstructure responses has not been studied. To enable precise manipulation proximal infant cues influence maternal behavior, we used a playback paradigm assess mothers' responsiveness prerecorded audiovisual clips unfamiliar infants' noncry...
Abstract What is the function of babbling in language learning? We examined structure parental speech as a contingency on infants’ non-cry prelinguistic vocalizations. analyzed several acoustic and linguistic measures caregivers’ speech. Contingent was less lexically diverse shorter utterance length than non-contingent also found that lexical diversity contingent only predicted infant vocal maturity. These findings illustrate new form influence infants have over their ambient everyday...
To assess the efficacy and safety of a sustained-release intracanalicular dexamethasone insert for treatment postoperative ocular inflammation pain in patients having cataract surgery.Twenty-one United States sites.Prospective multicenter randomized parallel-arm double-masked vehicle-controlled phase 3 study.Patients with planned clear corneal surgery were (1:1) to receive or placebo, was placed canaliculus eye immediately after (Day 1). The primary endpoints complete absence anterior...
purpose. Connective tissue growth factor (CTGF) has been linked to fibrosis in several tissues. In this study, the interactions between CTGF and transforming (TGF)-β were assessed human corneal fibroblasts, levels location of protein mRNA measured during healing excimer laser ablation wounds rat corneas. methods. Human fibroblasts incubated with TGF-β1, -β2, -β3 isoforms, measured. was immunolocalized cultured by using a specific antibody. Regulation collagen synthesis TGF-β neutralizing...
Summary Background The value of probiotics for primary prevention is controversial. Moreover, only little known about the underlying immunological mechanisms action. Therefore, we assessed proliferative response and cytokine release in cultures isolated mononuclear cells from pregnant women their neonates supplemented with Lactobacillus GG (LGG) or placebo. Methods In a double‐blind, placebo‐controlled prospective trial, at least one first‐degree relative partner an atopic disease were...
Purpose: Escalón is a prospective, randomized, double-masked, parallel-group trial designed to evaluate the safety and efficacy of cultured human corneal endothelial cells (CECs) Rho-associated protein kinase (ROCK) inhibitor Y-27632 for treating edema secondary dysfunction. Methods: Eligible eyes with bullous keratopathy (N = 18) or Fuchs dystrophy 4) were randomized receive polishing single intracameral injection containing 1 x 10 6 CECs 10, 20, 100 μM Y-27632. The primary outcome was...
Purpose This study aimed to compare the surgical outcomes of mitomycin C trabeculectomy glaucoma drainage device (GDD) surgery and laser neodymium:YAG (Nd:YAG) cyclophotocoagulation (CPC) in management intractable after penetrating keratoplasty (PKP) a retrospective study. Design Interventional case series. Participants/methods The medical charts consecutive patients who had pre-existing or developed PKP underwent procedure control at University Eye Associates Boston Medical Center, New...