A5066541082- Total Knee Arthroplasty Outcomes
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Zebrafish Biomedical Research Applications
- Animal Virus Infections Studies
- Ion channel regulation and function
- Shoulder Injury and Treatment
- Viral gastroenteritis research and epidemiology
- Osteoarthritis Treatment and Mechanisms
- Cancer Genomics and Diagnostics
- Orthopaedic implants and arthroplasty
- Knee injuries and reconstruction techniques
- Cardiac electrophysiology and arrhythmias
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- SARS-CoV-2 and COVID-19 Research
- Nicotinic Acetylcholine Receptors Study
- Pancreatic and Hepatic Oncology Research
- Sports injuries and prevention
- Cell death mechanisms and regulation
- Pluripotent Stem Cells Research
- Extracellular vesicles in disease
- NF-κB Signaling Pathways
- Biological Activity of Diterpenoids and Biflavonoids
- Wnt/β-catenin signaling in development and cancer
Zhongda Hospital Southeast University
2025
National University of Singapore
2018-2024
Affiliated Hospital of Nantong University
2024
Nantong University
2024
Southern Medical University
2022
Ningxia Medical University General Hospital
2021
Ningxia Medical University
2021
Jilin University
2020
First Hospital of Jilin University
2020
Third Affiliated Hospital of Southern Medical University
2020
Abstract Oleuropein is one of the most abundant phenolic compounds found in olives. Epidemiological studies have indicated that an increasing intake olive oil can significantly reduce risk breast cancer. However, potential effect(s) oleuropein on estrogen receptor (ER)‐negative cancer not fully understood. This study aims to understand anticancer effects and underlying mechanism(s) ER‐negative cells vitro. The effect viability cell lines was examined by mitochondrial dye‐uptake assay,...
Intra-articular injection has emerged as a promising approach for treating knee osteoarthritis (OA), showing notable efficacy and potential. However, the risk of side effects remains concern with commonly used steroid therapies in clinical practice. Here, we developed an intra-articular injectable hydrogel drug depot (SMN-CeO2@G) sustained OA treatment. This system, which carries sinomenine-loaded cerium dioxide nanoparticles (SMN-CeO2), enhances anti-inflammatory anti-apoptotic within joint...
Coronavirus (CoV) 3C-like proteinase (3CLpro), located in nonstructural protein 5 (nsp5), processes the replicase polyproteins 1a and 1ab (pp1a pp1ab) at 11 specific sites to produce 12 mature proteins (nsp5 nsp16). Structural biochemical studies suggest that a conserved Gln residue P1 position is absolutely required for efficient cleavage. Here, we investigate effects of amino acid substitution 3CLpro cleavage infectious bronchitis virus (IBV) on efficiency viral replication by vitro assays...
The brain ventricular system is essential for neurogenesis and homeostasis. Its neuroepithelial lining effects these functions, but the underlying molecular pathways remain to be understood. We found that potassium channels expressed in cells determine formation of system. phenotype a novel zebrafish mutant characterized by denudation hydrocephalus mechanistically linked Kcng4b, homologue ‘silent’ voltage-gated channel α-subunit Kv6.4. demonstrated Kcng4b modulates proliferation maintains...
The boundaries of brain regions are associated with the tissue-specific secretion ligands from different signaling pathways. dynamics these in vivo and impact its disruption remain largely unknown. Using light fluorescence microscopy for overall imaging specimen correlation spectroscopy (FCS) to determine Wnt3 dynamics, we demonstrated that regulates cerebellum development during embryogenesis using zebrafish wnt3 transgenics either expression an EGFP reporter or a functionally active fusion...
Abstract The metastasis of breast cancer is believed to have a negative effect on its prognosis. Benefiting from the remarkable deep-penetrating and noninvasive characteristics, sonodynamic therapy (SDT) demonstrates whole series potential leading treatment. To relieve limitation monotherapy, multifunctional nanoplatform has been explored realize synergistic treatment efficiency. Herein, we establish novel nano-system which encapsulates chlorin e6 (Ce6, for SDT), perfluoropentane (PFP,...
Early life radiation exposure causes abnormal brain development, leading to adult depression. However, few studies have been conducted explore pre- or post-natal irradiation-induced depression-related neuropathological changes. Relevant molecular mechanisms are also poorly understood. We induced depression by irradiation of mice at postnatal day 3 (P3) reveal hippocampal changes and investigate their mechanism, focusing on MicroRNA (miR) its target mRNA protein. P3 were irradiated γ-rays...
The voltage gated (Kv) slow-inactivating delayed rectifier channel regulates the development of hollow organs zebrafish. functional consists tetramer electrically active Kcnb1 (Kv2.1) subunits and Kcng4b (Kv6.4) modulatory or silent subunits. two mutations in zebrafish kcng4b gene – kcng4b-C1 kcng4b-C2 (Gasanov et al., 2021) have been studied during ear using electrophysiology, developmental biology silico structural modelling. mutation causes a C-terminal truncation characterized by mild...
Objective To investigate the six degrees of freedom (6 DOF ) kinematics anterior cruciate ligament ( ACL deficient knees during gait and to explore clinical significance a novel knee joint stability assessment system (Opti_Knee, Innomotion, Shanghai, China) in comparison with imaging arthroscopic examination. Methods Three subjects diagnosed on basis preoperative MRI CT findings were subjected treadmill analysis. Motion both 6 was measured analyzed an optical measurement system. Arthroscopic...
NFκB signaling has a pivotal role in regulation of development, innate immunity, and inflammation. Ikk2 is one the two critical kinases that regulate pathway. While inflammation oncogenesis received attention, an understanding vertebrate development been compounded by embryonic lethality seen mice lacking Ikk2. We find despite abnormal angiogenesis IKK2 zygotic mutants zebrafish, maternal activity supports embryogenesis maturation fertile animals allows to study development. Maternal-zygotic...
Objective To assess the difference between posterior condylar angle (PCA) and mechanical lateral distal femoral (mLDFA) in osseous cartilaginous contours a non-arthritic Chinese population. Methods Computed tomography (CT) magnetic resonance imaging (MRI) were obtained from 83 patients with knee injuries before arthroscopy, femur cartilage three-dimensional (3D) models constructed. The 3D model was arranged to share physical space model, then PCA mLDFA measured on contours, respectively....
Phytoestrogens have a similar molecular structure to estrogens which can produce either estrogenic or anti-estrogenic effects. It is generally believed that phytoestrogens combine with the estrogen receptor of osteosarcoma cells, affecting variety signal transduction pathways and cell metabolism, resulting in altered proliferation, differentiation, apoptosis, invasion migration ability. Formononetin (FN) active ingredient traditional Chinese medicine astragalus, angelica, Pueraria lobate....
Among the various types of cell death induced by ionizing radiation, apoptosis is a highly regulated and well-characterized form. Investigating radiation-induced in an intact organism offers advantages capturing dynamics under preserved physiology, although high resolution imaging remains challenging. Owing to their optical transparency genetic amenability, zebrafish ideal animal model for research into this aspect. In study, we present secA5 transgenic expressing genetically encoded...
Genotyping zebrafish carrying wild-type, heterozygous, or homozygous copies of a mutant allele is often required for investigating gene specific functions, and routinely performed to differentiate point mutants. In this study, we describe modified allele-specific PCR method using an additional blocking primer promote target sequence amplification while suppressing sequences with single mismatch. Using the
Objective To evaluate the diagnostic performance of plasma miR-499 in acute myocardial infarction (AMI) diagnosis. Methods Diagnostic accuracy test.The suspected AMI patients,who with chest pain for more than half an hour and been admitted Second People′s Hospital Wuxi First chuzhou during October 2010 July 2011,were consecutively prospectively enrolled present study.Sixty apparently healthy individuals were designed as control.The samples patients collected within two hours after...
Ionizing radiation exposure induces significant DNA damage and cell death in aquatic species. Accurate sensing quantification play pivotal roles environmental monitoring surveillance. Zebrafish (Danio rerio) is a well-suited animal model for research into this aspect, especially with recent development of cytogenetic transgenic tools. In study, we present time-course studies chromosome aberrations zebrafish embryos exposed to 2 Gy 137Cs total-body irradiation. Using approach, quantified...