A5108047083- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Liver Disease and Transplantation
- Boron and Carbon Nanomaterials Research
- Reproductive Physiology in Livestock
- MicroRNA in disease regulation
- Neurobiology and Insect Physiology Research
- Cephalopods and Marine Biology
- Circular RNAs in diseases
- Cancer Treatment and Pharmacology
- RNA Research and Splicing
- Graphene research and applications
- Superconductivity in MgB2 and Alloys
- Immune Response and Inflammation
- Immune cells in cancer
- MXene and MAX Phase Materials
- Management of metastatic bone disease
- Estrogen and related hormone effects
- Extracellular vesicles in disease
- PI3K/AKT/mTOR signaling in cancer
- Atherosclerosis and Cardiovascular Diseases
- Bioactive Compounds and Antitumor Agents
- Diet, Metabolism, and Disease
- Gout, Hyperuricemia, Uric Acid
- Assistive Technology in Communication and Mobility
Henan University
2025
University of Southern California
2025
Nanjing University
2017-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Sichuan University
2018-2022
The People's Hospital of Guangxi Zhuang Autonomous Region
2014-2022
Chengdu University
2022
Huazhong University of Science and Technology
2019-2021
Chinese Institute for Brain Research
2020
Soochow University
2018
Abstract Ferroptosis is a new type of programmed cell death characterized by iron-dependent lipid peroxidation. inhibition thought as promising therapeutic strategy for variety diseases. Currently, majority known ferroptosis inhibitors belong to either antioxidants or iron-chelators. Here we report inhibitor, termed YL-939, which neither an antioxidant nor iron-chelator. Chemical proteomics revealed the biological target YL-939 be prohibitin 2 (PHB2). Mechanistically, binding PHB2 promotes...
Cell surface engineering is an emerging technology to encapsulate cells in order enhance their functions. However, methods for reversible encapsulation of with abiotic functionalities are rare. Herein, we describe a phenylboronic acid based click reaction single yeast using mesoporous silica nanoparticles (MSNs). This does not impact natural growth the and leads significant enhancement cell survival variety hostile environments. Owing glucose-responsiveness boronate ester bond between...
Abstract 17β‐Estradiol (E2) is well known to interact with intracellular receptors that act as nuclear transcription factors. However, abundant evidence now indicates E2 can also rapidly induce several nongenomic effects through signaling pathways related cell growth, preservation, and differentiation. We studied the of in two human endometrial carcinoma lines, Ishikawa (estrogen receptor (ER) positive) Hec‐1A (ER negative or low) by cultivating them either its membrane‐impermeable...
A better understanding of neuromodulation in a behavioral system requires identification active modulatory transmitters. Here, we used identifiable neurons neurobiological model system, the mollusc Aplysia, to study neuropeptides, diverse class neuromodulators. We took advantage two types feeding neurons, B48 and B1/B2, Aplysia buccal ganglion that might contain different neuropeptides. performed representational difference analysis (RDA) by subtraction mRNAs versus B1/B2. The RDA identified...
Obesity commonly co-exists with fatty liver disease increasing health burden worldwide. Family Sequence Similarity 13, Member A (FAM13A) has been associated lipid levels and fat mass by genome-wide association studies (GWAS). However, the function of FAM13A in maintaining metabolic homeostasis vivo remains unclear. Here, we demonstrated that rs2276936 this locus allelic-enhancer activity massively parallel reporter assays (MPRA) assay. The DNA region containing regulates expression...
Abstract Aim To determine the tolerance and acceptance of hepatic venous pressure gradient (HVPG) measurements in patients with liver cirrhosis. Methods This prospective international multicenter study included 271 cirrhosis who were scheduled to undergo HVPG measurement between October 2019 June 2020. Data related collected using descriptive questionnaires. Results technically successful all patients, 141 (52.0%) undergoing alone. The complication rate was 0.4%. Postoperative pain...
Locomotion in mollusc Aplysia is implemented by a pedal rolling wave, type of axial locomotion. Well-studied examples locomotion (pedal waves Drosophila larvae and body leech, lamprey, fish) are generated segmented nervous system via activation multiple coupled central pattern generators (CPGs). Pedal molluscs, however, single ganglion, it unknown whether there or CPGs that generate rhythmic activity phase shifts between different parts. During intact , bursting the parapedal commissural...
Novel FeB49 nanorods homogeneously coated with protective boron nitride sheaths (h-BN-FeB49 nanocomposites) have been synthesized through a simple chemical vapor deposition (CVD) method at 1200 °C by controlling the ratio of Boron/iron trioxide and heating rate. Detailed electron microscopy studies reveal two kinds h-BN-FeB49 nanocomposites different structures morphologies: one is sandwich-type structure named BN-FeB-10 [B : Fe2O3 = 10] which constructed filling along growth axes closed end...
The structure of ZrB 2 under high-pressure was predicted by Particle Swarm Optimization method (CALYPSO). We investigated the stability, phonon dispersion curve, elasticity, electronic and thermodynamic properties high-temperature via first-principles calculations. It maintained hexagonal when pressure lowers below 600 GPa at 0 K, which is confirmed calculated curve. Studies indicate that elastic modulus Poisson’s ratio increase monotonically with pressure, as supported some theoretical...
The aim of this study is to screen and identify microRNAs (miRNAs) candidates determine their clinical relevance for different irritable bowel syndrome (IBS) subtype. Based on the Rome III criteria, five patients diagnosed with diarrhea‐predominant IBS(IBS‐D), constipation‐predominant IBS (IBS‐C) healthy volunteers were enrolled study. All people in both groups voluntarily joined informed consents. Endoscopic biopsy samples first collected from colon sigmoideum each subject frozen liquid...
Autism spectrum disorder (ASD) is a developmental characterized by significant social communication impairments and difficulties perceiving presenting cues. Machine learning techniques have been broadly adopted to facilitate autism studies assessments. However, computational models are primarily concentrated on specific analysis validated private datasets in the community, which limits comparisons across due privacy-preserving data sharing complications. This work presents novel open-source...