A5100361277- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Trace Elements in Health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Prion Diseases and Protein Misfolding
- TGF-β signaling in diseases
- Cancer Treatment and Pharmacology
- Anesthesia and Pain Management
- Colorectal Cancer Treatments and Studies
- E-commerce and Technology Innovations
- Animal Virus Infections Studies
- Colorectal Cancer Screening and Detection
- Renal Diseases and Glomerulopathies
- Monoclonal and Polyclonal Antibodies Research
- Economic and Financial Impacts of Cancer
- Biochemical effects in animals
- Gastric Cancer Management and Outcomes
- Advanced Technology in Applications
- Colorectal Cancer Surgical Treatments
- Electrolyte and hormonal disorders
Capital Medical University
2009-2025
Beijing Friendship Hospital
2025
Beijing Shijitan Hospital
2020-2023
Shanghai Public Health Clinical Center
2023
Shandong First Medical University
2023
Shandong Tumor Hospital
2023
Shandong University
2023
Fudan University Shanghai Cancer Center
2023
The Sixth People's Hospital of Shenyang
2022
Fred Hutch Cancer Center
2021
Wilson's disease (WD) is a genetic disorder that impairs the excretion of copper in hepatocytes and results excessive deposition multiple organs. The replacement disordered with functional can serve as lifelong therapeutic strategy for treatment WD. aim this study was to determine hepatocyte repopulation effects fibroblast-derived hepatic progenitor cells Induced (iHPCs) were generated through direct reprogramming adult mouse fibroblasts infected lentivirus carrying both Foxa3 Hnf4α genes....
Abstract Background To develop and validate nomograms that can be used to predict outcomes in individuals suffering alpha‐fetoprotein (AFP) negative hepatocellular carcinoma (HCC) after radical resection. Methods A total of 509 AFP‐negative HCC patients who received hepatectomy between January 2009 March 2013 our center were randomized into training validation cohorts. Nomograms for both overall recurrence‐free survival (OS RFS, respectively) established based on the predictors cohort....
Soya isoflavones (SIF) and folic acid (FA) both confer the biological properties of antioxidation; however, mechanism their antioxidant effect on nervous system development is unclear. Our purpose to investigate neuroprotective effects SIF, FA or co-administration SIF with against β-amyloid 1-40 (Aβ1-40)-induced learning memory impairment in rats. In present study, ability rats amount amyloid-positive neurons cerebral cortex hippocampal CA1 area were measured. The levels total capacity...
Cells from primary porcine hepatocytes (PPH) and the immortalized human hepatoma cell line C3A are both used in bioartificial liver support systems (BALSS). In this work viability metabolic capacity of PPH cells cultured different media were compared. Also, because come into direct or indirect contact with blood components BALSS, effects complement on survival functions was evaluated. For short-term culture, maintenance essential for retention P450IA1 activity (r = 0.882, p < 0.01) effective...
The aim of the present research was to study therapeutic impacts fluorofenidone (AKF-PD) on pig serum (PS)-induced liver fibrosis in rats and complex molecular mechanisms its effects hepatic stellate cells (HSCs). Wistar were randomly divided into normal control, PS PS/AKF-PD treatment groups. activated human HSC LX-2 cell line also treated with AKF-PD. expression collagen I III, α-smooth muscle actin (α-SMA) determined by immunohistochemical staining reverse transcription-quantitative...
Abstract Aim To determine the tolerance and acceptance of hepatic venous pressure gradient (HVPG) measurements in patients with liver cirrhosis. Methods This prospective international multicenter study included 271 cirrhosis who were scheduled to undergo HVPG measurement between October 2019 June 2020. Data related collected using descriptive questionnaires. Results technically successful all patients, 141 (52.0%) undergoing alone. The complication rate was 0.4%. Postoperative pain...
This study aimed to evaluate the long-term outcomes and efficacy of continued ligation plus cyanoacrylate injection compared with those combined sclerotherapy for secondary prophylaxis variceal bleeding in cirrhotic patients concomitant esophageal gastric varices.Medical records who were admitted due liver cirrhosis retrospectively reviewed their related data was collected. The divided into two groups, including group [the (-) group] (+) group]. Kaplan-Meier survival analysis conducted...
Though the treatment landscape for hepatocellular carcinoma (HCC) has evolved significantly with refinement of liver-directed therapy techniques and introduction new drugs, few studies have investigated impact changing on lifetime costs, particularly in Barcelona Clinic Liver Cancer (BCLC) stage C disease. We sought to investigate real-world clinical characteristics, patterns, healthcare costs a cohort HCC patients treated at single high-volume institution Washington (WA) state.We conducted...
The Baveno VI criteria based on platelet count and liver stiffness, measured by transient elastography (TE), have been proposed to rule out high-risk varices (HRV) defined as medium or large-sized the presence of stigmata (cherry red spots wale marks). However, TE is not available in all hospitals. Recently, Rete Sicilia Selezione Terapia hepatitis C virus (RESIST-HCV) recommended that cirrhotic patients with a > 120000/μL serum albumin 36 g/L could avoid esophagogastroduodenoscopy (EGD)...
Influence of transitional nursing on the compliance behavior and disease knowledge children with purpura nephritis
Background & Aims: Wilson’s disease (WD) is a genetic disorder that impairs the excretion of copper in hepatocytes and results excessive deposition multiple organs. Replacement disordered by functional can serve as lifelong therapeutic strategy for WD.Methods: Induced hepatocyte progenitor cells (iHPCs) were obtained direct reprogramming primary fibroblasts from adult C57BL/6J mice infected with lentivirus carrying two genes Foxa3 Hnf4α. After identification, iHPCs transplanted into...
Studies concerning the impact of air temperature on esophagogastric variceal bleeding (EGVB) have yielded conflicting results. Our study aimed to evaluate correlation between and EGVB.A time-stratified case-crossover design was performed. Patients received emergency gastroscopic hemostasis for upper gastrointestinal Jan 1, 2014, Dec 31, 2018 in Fifth Medical Center PLA General Hospital were enrolled. Conditional logistic regression analysis applied determine association EGVB different lag...
Abstract Background : Hepatic encephalopathy is the primary cause of mortality in cases liver cirrhosis. The Psychometric Encephalopathy Score (PHES) widely acknowledged as a gold standard for diagnosis covert hepatic encephalopathy. However, PHES burdensome due to its strict indications and not readily embraced by clinicians. Consequently, there an imperative identify simpler clinical indicators PHES. Methods This retrospective cross-sectional study utilized data from single center....
Liver plays a central role in health and homeostasis thus the diseased liver leads to many harmful effects on multiple organ systems,including pulmonary system. The general of cirrhosis respiratory system, including mild hypoxemia, atelectasis hepatic hydrothorax. Cirrhosis is associated with two unique entities that affect vasculature: hepatopulmonary syndrome (or) portopulmonary hypertension. Hepatopulmonary characterized by intrapulmonary vascular dilatations,while hypertension elevated...
Background and Aims: The Baveno VI expanded-Baveno criteria has been validated as single-use screening for varices needing treatment (VNT) in patients enriched with hepatitis C virus alcoholic-related compensated cirrhosis. Here, we aimed to develop validate novel CHESS model dynamic monitoring of VNT predominantly B (HBV)-related Methods: A total 3,470 cirrhosis from China, Singapore India were included the international multicenter study six cohorts follows: real-world cohort; validation...