A5040859310- Acute Myeloid Leukemia Research
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- Immune Cell Function and Interaction
- Ectopic Pregnancy Diagnosis and Management
- Blood groups and transfusion
- Liver Disease Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Organ Transplantation Techniques and Outcomes
- Pregnancy and Medication Impact
- Liver Disease and Transplantation
- Neuroendocrine Tumor Research Advances
- Lysosomal Storage Disorders Research
- Hematopoietic Stem Cell Transplantation
- Nail Diseases and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Erythrocyte Function and Pathophysiology
- Fungal Infections and Studies
- Blood properties and coagulation
- Hematological disorders and diagnostics
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2015-2025
Centre de Recherche Saint-Antoine
2016-2025
Hôpital Saint-Antoine
2016-2025
Inserm
2017-2025
Hôpital Européen Georges-Pompidou
2018-2024
Université Paris Cité
2020-2024
Hôpital Cochin
2022
Sorbonne Paris Cité
2022
Hôpital Armand-Trousseau
2016
Abstract Clonal hematopoiesis (CH) of indeterminate potential has been described in blood samples from large series patients. Its prevalence and consequences are still not well understood because sequencing methods vary most studies were performed cohorts comprising individuals with nonhematologic diseases. Here, we investigated the frequency CH 82 paired bone marrow carefully selected healthy adult volunteers. Forty-one genes known to be mutated myeloid malignancies sequenced a 1% threshold...
The genetic landscape of adult acute myeloid leukemias (AML) has been recently unraveled. However, due to their heterogeneity, only a handful markers are currently used for the evaluation minimal residual disease (MRD). Recent studies using multi-target strategies indicate that detection mutations in less than 5% cells complete remission is associated with better survival. Here, series 69 AMLs known clonal architecture, we design clone-specific strategy based on fluorescent situ...
Summary Immune effector cell‐associated hematotoxicity (ICAHT) is a common toxicity associated with an important morbidity after chimeric antigen receptor (CAR)‐T‐cell therapy. Multiple factors seem to be involved in the development of severe ICAHT, making its management difficult. Here, we report three cases ICAHT axicabtagene‐ciloleucel (axi‐cel) for diffuse large B‐cell lymphoma showing expansion granular lymphocyte bone marrow CD3/CD57‐positive non‐CAR‐T immunophenotype. We show that it...
Background: Idarucizumab has been included in guidelines for the management of bleeding or surgical procedure dabigatran-treated patients without need biological monitoring. The aim study was to assess prognostic value dabigatran plasma level before reversal test hemostatic efficacy idarucizumab. secondary objectives were (i) analyze according risk rebound and (ii) evaluate incidence post-reversal non-favorable clinical outcomes (including thromboembolism, bleeding, antithrombotic, death)...
This prospective observational study was designed to analyze platelet functions across time in 50 patients scheduled for liver transplantation (LT) secondary decompensated cirrhosis or hepatocellular carcinoma. Platelet were assessed before LT (pre-LT), one week (D7) and 1 month (D28) after LT. count significantly increased from pre-LT day 28 as well circulating CD34+hematopoietic stem cells. To avoid any influence of on assays, function evaluated platelet-rich-plasma adjusted count....
A 73-year-old man presented with fatigue and diffuse bone pain. Workup showed pancytopenia, long-bone osteonecrosis, Gaucher’s cells on marrow biopsy.
Recurrent miscarriages are defined as three or more early before 12 weeks of gestation. The aim this study was to describe a cohort women with unexplained recurrent miscarriages, evaluate several potential biomarkers immune origin, and the outcome pregnancies under immunomodulatory therapies.Women having history at least 3 without any etiology were recruited from university hospitals.Among 101 overall, 652 have been included in analysis. Women which experienced older (33.3 ± 5.4 versus 31.9...
A 56-year-old Afro-Caribbean woman was admitted to our institution with a recent history of weakness, fever, hepatosplenomegaly and pancytopenia. Previous examinations tests had been inconclusive. On admission her full blood count showed haemoglobin concentration 63 g/l, platelet 41 × 109/l leucocyte 3·9 (neutrophils 1·3 109/l). Biochemical investigations elevated C-reactive protein (188 mg/l), lactate dehydrogenase (1898 iu/l) triglycerides (5·7 mmol/l). The pancytopenia the suspicion...
Chemotherapy resistance is the main cause of treatment failure in acute myeloid leukemia (AML) and has been related to ATP-binding cassette (ABC) transporter activity. However, links between ABC activity, immunophenotype, molecular AML parameters have poorly evaluated. Moreover, prognostic value when compared new markers, unknown. Here we investigated as evaluated by JC-1 +/- cyclosporine A assay, immunophenotypic, cytogenetic, molecular, targeted next-generation sequencing features 361...