A5053908538- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Reproductive Biology and Fertility
- Pregnancy and Medication Impact
- Ovarian function and disorders
- Ectopic Pregnancy Diagnosis and Management
- Reproductive Physiology in Livestock
- Pregnancy and preeclampsia studies
- Gynecological conditions and treatments
- Prenatal Screening and Diagnostics
- Sperm and Testicular Function
- Reproductive Health and Technologies
- COVID-19 Impact on Reproduction
- Uterine Myomas and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Preterm Birth and Chorioamnionitis
- Assisted Reproductive Technology and Twin Pregnancy
- Sexual Differentiation and Disorders
- Pregnancy-related medical research
- Organ and Tissue Transplantation Research
- MicroRNA in disease regulation
- Chromosomal and Genetic Variations
- Animal Genetics and Reproduction
- Birth, Development, and Health
- Urticaria and Related Conditions
Université de Versailles Saint-Quentin-en-Yvelines
2006-2025
Centre Hospitalier Universitaire de Lille
2024
Hôpital Jeanne de Flandre
2024
Paris Biotech Santé
2018-2023
Hôpital des Enfants
2022
Hôpital Cochin
2018-2020
Inserm
2007-2016
Hôpital Saint-Louis
2014-2016
Université Paris Cité
2012-2016
Délégation Paris 7
2012-2016
BACKGROUND: There is strong evidence that locally secreted cytokines control the implantation process and can cause failure. Uterine flushing fluids were analysed to determine their concentrations of leukaemia inhibitory factor (LIF) tumour necrosis (TNF). METHODS AND RESULTS: We began by uterine cavities 33 infertile patients on day 26 two consecutive cycles. The LIF (by enzyme-linked immunosorbent assay) TNF bioassay) significantly correlated during these cycles (r = 0.762, P 0.0001 r...
Labeled problem Embryo implantation remains the main limiting factor in assisted reproductive medicine (20% success rate). Methods of study An endometrial immune profiling was performed among 394 women with previous history repeated embryo failures (RIF). The profile documented ratio IL‐15/Fn‐14 mRNA as a biomarker uNK cell activation/maturation (together count) and IL‐18/TWEAK both angiogenesis Th1/Th2 balance. According to their profile, we recommended personalized care counteract...
Sperm samples are separated into bad and good quality in function of their phenotype, but this does not indicate genetic quality. Here, we used GeneChip miRNA arrays to analyze microRNA expression ten semen selected based on high-magnification morphology (score 6 vs. score 0) identify miRNAs linked sperm phenotype. We found 86 upregulated 21 downregulated good-quality 6) compared with bad-quality (fold change > 2 p-value < 0.05). MiR-34 (FC × 30, p = 8.43 10-8), miR-30 12, 3.75 10-6),...
To evaluate the effect of an antifibrotic treatment by a combination pentoxifylline (PTX) and tocopherol (vitamin E) in patients with thin endometrium who were enrolled oocyte donation programme.Eighteen recipients failed to develop pre-ovulatory endometrial thickness at least 6 mm after receiving vaginal micronized estradiol study. The received PTX (800 mg/day) vitamin E (1000 IU/day) for months. main outcome measurements change pregnancy delivery rates treatment.Endometrial increased...
The cytokine/chemokine levels of individual follicular fluids (FFs) were measured to determine whether a biomarker could be linked the developmental potential derived embryo.Fluid was collected from 132 FFs that source oocytes subsequently fertilized and transferred. In each, bead-based multiplex sandwich immunoassay (Luminex) used measure 28 cytokines chemokines simultaneously.Significantly higher interleukin (IL-2) interferon (IFN-gamma) detected in FF for embryos underwent early cleavage....
The objective was to examine if IVF/ICSI repeated implantation failures (IF) or recurrent miscarriages (RM) could be related preconceptional endometrial deregulations. IF defined as the absence of pregnancy despite transfer at least ten good quality embryos, and RM having three unexplained miscarriages. Fertile controls (FC) were women who had given birth once. Endometrial biopsy performed in mild luteal phase a non-conceptual cycle (five selected each group). Affymetrix chips (GeneChip...
Previous experiments have shown that granulocyte colony-stimulating factor (G-CSF), quantified in the follicular fluid (FF) of individual oocytes, correlates with potential for an ongoing pregnancy corresponding fertilized oocytes among selected transferred embryos. Here we present a proof concept study aimed at evaluating impact including FF G-CSF quantification embryo transfer decisions. was Luminex XMap technology 523 samples to 116 fresh embryos, 275 frozen embryos and 131 destroyed from...
Introduction Recombinant human Granulocyte-Colony Stimulating Factor (rhG-CSF) supplementation seems to be a promising innovative therapy in reproductive medicine, used case of recurrent miscarriage, embryo implantation failure or thin endometrium, although its mechanisms action remain unknown. Our aim was identify possible endometrial pathways influenced by rhG-CSF. Materials and Methods Hypothetical molecular interactions regulated G-CSF were designed through previous large scale...
The chemokine stromal cell-derived factor 1 (SDF-1) stimulates the growth of pre-B cells in vitro , and mice with a disrupted SDF-1 gene have abnormal fetal liver B cell lymphopoiesis. origin production has not been determined yet. Using an anti-SDF-1 mAb, we performed immunohistochemical studies four human embryos five fetuses to define which express protein at sites antenatal All mesothelial contained all stages development, including intraembryonic splanchnopleuric mesoderm early into...
To assess the efficiency of endometrial immune profiling as a method to design personalized care enhance pregnancy rate in large heterogeneous infertile population. We hypothesized that some reproductive failures could be induced by uterine dysregulation which identified and corrected with targeted plan.