A5039736912- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Venous Thromboembolism Diagnosis and Management
- Infective Endocarditis Diagnosis and Management
- Coronary Interventions and Diagnostics
- Streptococcal Infections and Treatments
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- COVID-19 Clinical Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Extracellular vesicles in disease
- Cardiac Valve Diseases and Treatments
- Pregnancy and preeclampsia studies
- Systemic Lupus Erythematosus Research
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 and COVID-19 Research
- Angiogenesis and VEGF in Cancer
- Diabetes Treatment and Management
- Sepsis Diagnosis and Treatment
- Bartonella species infections research
- Orthopedic Infections and Treatments
- Complement system in diseases
Hôpital de la Timone
2013-2023
Aix-Marseille Université
2009-2023
Institut de Recherche pour le Développement
2012-2023
Méditerranée Infection Foundation
2017-2023
Assistance Publique Hôpitaux de Marseille
2002-2023
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2017-2020
Hôpital Nord
2006-2020
Inserm
2006-2017
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
2012-2017
Centre National de la Recherche Scientifique
2002-2017
Microparticles (MPs) resulting from vesiculation of platelets and other blood cells have been extensively documented in vitro found increased numbers several vascular diseases, but little is known about MPs endothelial origin. The aim this study was to analyze morphological, immunological, functional characteristics derived human umbilical vein (HUVECs) stimulated by TNF, investigate whether these are detectable healthy individuals patients with a prothrombotic coagulation abnormality....
Abstract We carried out a prospective evaluation of new vasodilator‐stimulated phosphoprotein (VASP) phosphorylation assay in order to detect patients with high‐risk coronary subacute stent thrombosis (SAT) despite thienopyridine regimen. Twenty healthy donors (group 1) without any medication were compared 16 stented 2) treated by ticlopidin or clopidogrel initiated 2 days before stenting and aspirin (250 mg/day). No difference platelet reactivity was noted between group 1 only (72.00% ±...
In our institute in Marseille, France, we initiated early and massive screening for coronavirus disease 2019 (COVID-19). Hospitalization treatment with hydroxychloroquine azithromycin (HCQ-AZ) was proposed the positive cases.
Summary The antiphospholipid syndrome (APS) refers to persistent antibodies (aPL) associated with thrombotic and/or obstetrical complications. endothelial cell is a target of aPL which can induce procoagulant and proinflammatory phenotype, as reported both in vivo vitro. Microparticle production hallmark activation. In the present study, presence microparticles (EMP) plasma APS patients was investigated. To determine if there correlation certain biological clinical features, EMP levels were...
Clopidogrel responsiveness has been proposed to be involved in recurrent ischemic events after stenting for non-ST elevation acute coronary syndromes (NSTE ACS). However, its biological definition is not consensual. We assess the value of ADP-induced platelet aggregation (ADP-Ag) and reactivity index VASP (PRI VASP) predicting patients with NSTE ACS undergoing percutaneous intervention (PCI). studied 195 consecutive PCI a 600 mg loading dose clopidogrel. ADP-Ag PRI were analysed. The primary...
Post-treatment platelet reactivity (PR) is associated with ischemic and bleeding events in patients receiving P2Y12 receptor antagonists.We aimed to study the relationship between post-treatment PR after a 60-mg loading dose (LD) of prasugrel 1-year thrombotic events.Patients were prospectively included this multicenter if they had successful percutaneous coronary intervention (PCI) for acute syndrome (ACS) received prasugrel. The index (PRI) was measured using Vasodilator-Stimulated...
As the coronavirus disease 2019 (COVID-19) pandemic has spread throughout world, important efforts have been made to describe its physiopathology and complications.In critically ill patients with COVID-19, a systemic inflammatory response associated endothelial activation is observed. 1A high rate of thrombotic complications described, including deep vein thrombosis. 2 Although mechanisms thrombosis are unclear, anticoagulation doses heparin proposed for these patients.Heparin-induced...
<h3>Importance</h3> Blood transfusion is a mainstay of therapy for trauma-induced coagulopathy, but the optimal modalities plasma in prehospital setting remain to be defined. <h3>Objective</h3> To determine whether lyophilized can reduce incidence coagulopathy compared with standard care consisting normal saline infusion. <h3>Design, Setting, and Participants</h3> This randomized clinical trial was performed at multiple centers France involving medical teams. Participants included 150 adults...
Abstract Angiogenesis is a critical event in tumor growth and metastasis, which can be inhibited by conventional anticancer drugs such as the microtubule-damaging agent paclitaxel (Taxol). In this study, we investigate mechanism of action on human endothelial cells. We characterize two distinct effects umbilical vein cell microvascular cell-1 proliferation according to drug concentration: cytostatic effect at low concentrations cytotoxic 10 nmol/L. The involves signaling pathways similar...
In the present study, we explored microparticles involved in control of hemostatic equilibrium, i.e originating from platelet, endothelial cells and total MP defined as annexin V positive microparticles. Our aim was to analyze level procoagulant activity these normal pregnancy pregnancies complicated with preeclampsia or isolated intrauterine growth restriction. We reported increased levels platelet compared non pregnant healthy women. Number significantly together their activity....