A5005759601- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- RNA modifications and cancer
- Gene Regulatory Network Analysis
- Mathematical Biology Tumor Growth
- Cancer-related molecular mechanisms research
- Phosphodiesterase function and regulation
- Retinal Development and Disorders
- Cholinesterase and Neurodegenerative Diseases
- Cardiac electrophysiology and arrhythmias
- CRISPR and Genetic Engineering
- Cancer, Lipids, and Metabolism
- Virus-based gene therapy research
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- ECG Monitoring and Analysis
- Renal cell carcinoma treatment
- Bioinformatics and Genomic Networks
- Kruppel-like factors research
- Viral Infections and Immunology Research
- MicroRNA in disease regulation
- Glutathione Transferases and Polymorphisms
- Cancer Cells and Metastasis
- Amino Acid Enzymes and Metabolism
- Metabolism and Genetic Disorders
University of Oxford
2018-2025
John Radcliffe Hospital
2019-2021
Institute of Molecular Medicine
2021
Molecular Oncology (United States)
2021
MRC Weatherall Institute of Molecular Medicine
2018-2019
Universidad de Oviedo
2015
Instituto de Investigación Sanitaria del Principado de Asturias
2015
Central University Hospital of Asturias
2010-2011
Abstract Heterozygous germline mutations in BRCA2 predispose to breast and ovarian cancer. Contrary non-cancerous cells, where deletion causes cell cycle arrest or death, tumors carrying inactivation continue proliferate. Here we set out investigate adaptation loss of focusing on genome-wide transcriptome alterations. Human cells which expression is inhibited for 4 28 days are subjected RNA-seq analyses revealing a biphasic response abrogation. The early, acute consists downregulation genes...
Hypoxia is a common phenomenon in solid tumors and strongly linked to hallmarks of cancer. Recent evidence has shown that hypoxia promotes local immune suppression. Type I IFN supports cytotoxic T lymphocytes by stimulating the maturation dendritic cells enhancing their capacity process present antigens. However, little known about relationship between type pathway, which comprises sensing double-stranded RNA DNA (dsRNA/dsDNA) followed IFNα/β secretion transcriptional activation...
Hypoxia is a common phenomenon in solid tumours strongly linked to the hallmarks of cancer. promotes local immunosuppression and downregulates type I interferon (IFN) expression signalling, which contribute success many cancer therapies. Double-stranded RNA (dsRNA), transiently generated during mitochondrial transcription, endogenously activates IFN pathway. We report effects hypoxia on generation dsRNA (mtdsRNA) breast found significant decrease production different cell lines under...
Deregulated metabolism is one of the hallmarks cancer. It well-known that tumour cells tend to metabolize glucose via glycolysis even when oxygen available and mitochondrial respiration functional. However, lower energy efficiency aerobic with respect makes this behaviour, namely Warburg effect, counter-intuitive, although it has now been recognized as source anabolic precursors. On other hand, there evidence oxygenated could be fuelled by exogenous lactate produced from glycolysis. We...
Abstract Background PDE6H encodes PDE6γ′, the inhibitory subunit of cGMP-specific phosphodiesterase 6 in cone photoreceptors. Inhibition PDE6, which has been widely studied for its role light transduction, increases cGMP levels. The purpose this study is to characterise cancer cell growth. Methods From an siRNA screen 487 genes involved metabolism, was identified as a controller cycle progression HCT116 cells. Role growth and metabolism through effects depletion on levels controllers, mTOR...
ABSTRACT Intratumoural heterogeneity contributes to local tumour recurrence and variable responses radiotherapy in prostate cancer. Despite the multiclonal nature of disease, control probability for conventional treatment plans is modelled on assumption that cells target region respond identically independently. Here, using cell subpopulations with different radiation sensitivities from lines, we show resistant enhance survival resistance radio-sensitive spheroids but not monolayer culture....
Abstract Background In clear cell renal carcinoma, 80% of cases have biallelic inactivation the VHL gene, leading to constitutive activation both HIF1α and HIF2α. As HIF2α is driver disease promoting tumour growth metastasis, drugs targeting been developed. However, resistance common, therefore new therapies are needed. Methods We assessed effect antagonist PT2385 in several steps development performed RNAseq identify genes differentially expressed upon treatment. A drug screening was used...
ABSTRACT Hypoxia is a common phenomenon in solid tumours strongly linked to the hallmarks of cancer. promotes local immunosuppression and downregulates type I interferon (IFN) expression signalling, which contribute success many cancer therapies. Double-stranded RNA (dsRNA), transiently generated during mitochondrial transcription, endogenously activates IFN pathway. We report effects hypoxia on generation dsRNA (mtdsRNA) breast found significant decrease production different cell lines...
Abstract Hypoxia is a common phenomenon in solid tumours and considered hallmark of cancer. Increasing evidence shows that hypoxia promotes local immune suppression. Type I IFN involved supporting cytotoxic T lymphocytes by stimulating the maturation dendritic cells (DCs) enhancing their capacity to process present antigens. However, there little information about relationship between type interferon (IFN) pathway, which comprises sensing double-stranded RNA DNA (dsRNA/dsDNA), followed...
<div>Abstract<p>Hypoxia is a common phenomenon in solid tumors and strongly linked to hallmarks of cancer. Recent evidence has shown that hypoxia promotes local immune suppression. Type I IFN supports cytotoxic T lymphocytes by stimulating the maturation dendritic cells enhancing their capacity process present antigens. However, little known about relationship between type pathway, which comprises sensing double-stranded RNA DNA (dsRNA/dsDNA) followed IFNα/β secretion...
<div>Abstract<p>Hypoxia is a common phenomenon in solid tumors and strongly linked to hallmarks of cancer. Recent evidence has shown that hypoxia promotes local immune suppression. Type I IFN supports cytotoxic T lymphocytes by stimulating the maturation dendritic cells enhancing their capacity process present antigens. However, little known about relationship between type pathway, which comprises sensing double-stranded RNA DNA (dsRNA/dsDNA) followed IFNα/β secretion...
<p>supplementary figures and materials</p>
<p>supplementary figures and materials</p>
ABSTRACT Deregulated metabolism is one of the hallmarks cancer. It well-known that tumour cells tend to metabolize glucose via glycolysis even when oxygen available and mitochondrial respiration functional. However, lower energy efficiency aerobic with respect makes this behaviour, namely Warburg effect, counter-intuitive, although it has now been recognized as a source anabolic precursors. On other hand, there evidence oxygenated could be fuelled by exogenous lactate produced from...
Heterozygous germline mutations in BRCA2 predispose to breast and ovarian cancer. Contrary non-cancerous cells, where deletion causes cell cycle arrest or death, inactivation tumors is associated with uncontrolled proliferation. We set out investigate this conundrum by exploring modalities of adaptation loss focused on genome-wide transcriptome alterations. Human cells which expression was inhibited using a doxycycline (DOX)-inducible shRNA for 4 28 days were subjected RNA-seq analyses. Gene...
Introduction: Hypoxia is a common phenomenon in solid tumors and considered hallmark of cancer. Increasing evidence shows that tumor hypoxia promotes local immune suppression inhibits cell killing functions. However, there little information about the relationship between type I interferon (IFN) pathway, which comprises sensing double-stranded RNA DNA (dsRNA/dsDNA) microenvironment, followed by IFNα/β secretion. The aim this study to determine effect on IFN pathway breast cancer consequences...